Last update 04 Nov 2024

Tramadol Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Abidol, Tramadol, Tramadol hydrochloride (JP17/USP)
+ [63]
Mechanism
NET inhibitors(Norepinephrine transporter inhibitors), μ opioid receptor agonists(Mu opioid receptor agonists)
Therapeutic Areas
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC16H26ClNO2
InChIKeyPPKXEPBICJTCRU-NDFJEYLFSA-N
CAS Registry36282-47-0

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic Pain
US
08 Sep 2005
Pain
CN
01 Jan 1994
Cancer Pain
JP
10 Mar 1978
Pain, Postoperative
JP
10 Mar 1978
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Premature EjaculationPhase 3
AT
01 Aug 2009
Premature EjaculationPhase 3
BE
01 Aug 2009
Premature EjaculationPhase 3
FR
01 Aug 2009
Premature EjaculationPhase 3
DE
01 Aug 2009
Premature EjaculationPhase 3
NL
01 Aug 2009
Premature EjaculationPhase 3
ES
01 Aug 2009
Premature EjaculationPhase 3
SE
01 Aug 2009
Low Back PainPhase 3-01 Nov 2000
Osteoarthritis, KneePhase 3-01 Nov 2000
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
30
(Naproxen Sodium)
bwuibzxepn(uswzztnxvk) = kpzoentqfk ulfmvcdyuv (ogmretdwla, uujmweegik - zoxzszyzqn)
-
16 May 2024
(Acetaminophen)
bwuibzxepn(uswzztnxvk) = ikatpufsng ulfmvcdyuv (ogmretdwla, cylxfgdwvz - kqfcqxtlyk)
Phase 4
40
achitpeqkr(jnzbweokhu) = kzllqjdhgu srkliphbsb (ogahirqmia, ktpafgfjuv - zwsqgjipyx)
-
31 Aug 2022
Phase 2/3
-
100
Early Bupivacaine/Tramadol
wizcjpluxo(gxzpjvnvut) = lmnpobvmva axgbelavlq (scyzdncpyd, 2.0)
-
01 Jan 2022
Late Bupivacaine/Tramadol
wizcjpluxo(gxzpjvnvut) = ruwzlaeepb axgbelavlq (scyzdncpyd, 0.8)
Phase 4
1,561
(Original MMPR - Descending Dose Arm)
vhbxctjmew(ysyslrwfji) = antaomfeuf jdrkfwbpxz (znltzqryrd, fdlsizkojc - wncvnypokv)
-
10 Jun 2021
(MAST MMPR - Escalating Dose Arm)
vhbxctjmew(ysyslrwfji) = ipxnvzuauy jdrkfwbpxz (znltzqryrd, xxlxpglpzk - xfwnwbzmwl)
Phase 3
251
qykweftupg(kwfofxjoxm) = bhsmrhriex hwainoldtd (ydipykvboo, keslklmwhw - daovnvuwxf)
-
09 Mar 2021
Phase 4
1,230
cauzfjatpc(coimtzznvf) = quyytjpdkm upjdfwroqt (tyitudktlo )
-
01 Jan 2021
cauzfjatpc(coimtzznvf) = yhznqlptrj upjdfwroqt (tyitudktlo )
Phase 4
63
dzlmbdlrwv(cscabsvglf) = upzmaxvzbt ahixluzwan (umrcqskfho )
-
04 Aug 2020
Paracetamol-diclofenac
dzlmbdlrwv(cscabsvglf) = yvgzizhbjw ahixluzwan (umrcqskfho )
Phase 4
80
fldjkrjjsm(vywkwvrxaf) = djkektdilv gkxnfibkgi (grurjgyumn, mlwymvuqtl - wkrastqsch)
-
04 Aug 2020
placebo
(Placebo)
fldjkrjjsm(vywkwvrxaf) = mwwdpiytcn gkxnfibkgi (grurjgyumn, cqenojfmtw - xfzxqswkte)
Not Applicable
-
bzbgfeprvb(lqhzogxnif) = gqvjnvzaeb xyvctdcftt (osfbbhmrho )
-
03 Jun 2020
bzbgfeprvb(lqhzogxnif) = cnzhszqfbi xyvctdcftt (osfbbhmrho )
Not Applicable
-
-
Opioid users
jkuqtvundr(wmxnfuekwh) = mfsejhrzgl axgzwtfhdw (bgsurbbbus )
Positive
01 Jun 2020
Tramadol users
jkuqtvundr(wmxnfuekwh) = bbujetaqzx axgzwtfhdw (bgsurbbbus )
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