The goal of this multicenter, randomized trial is to compare standby cannulated ECMO versus prophylactic ECMO in patients undergoing high-risk percutaneous coronary intervention (PCI). The main question it aims to answer is :
• If standby cannulated ECMO as compared with prophylactic ECMO will improve the outcomes in patients undergoing high-risk PCI

Start Date01 Dec 2024

Sponsor / Collaborator

Beijing Anzhen Hospital

[+9]

ChiCTR2400090871

/ SuspendedPhase 1IIT

High-flow nasal cannula therapy for perioperative use in elderly patients at high altitude (3650m)

Start Date15 Oct 2024

Sponsor / Collaborator

Xinjiang Autonomous Region People's Hospital

100 Clinical Results associated with Xinjiang Autonomous Region People's Hospital

0 Patents (Medical) associated with Xinjiang Autonomous Region People's Hospital

1,849

Literatures (Medical) associated with Xinjiang Autonomous Region People's Hospital

01 Apr 2025·Magnetic Resonance Imaging

Comparison of 3D BFFE and 3D TRANCE on pulmonary artery imaging with two T-SLIP placement strategies

Article

Author: Liu, Shuai ; Yu, Hong ; Tang, Xiaoying ; Zhu, Li ; Shang, Fei ; Wang, Yan ; Qu, Yuan

3D BFFE and TRANCE can provide a visualization of pulmonary vessels without injection of contrast agent. T-SLIP can observe a large area of vessels using an arterial spin labeling technique. 3D BFFE and TRANCE with two T-SLIP placement strategies were compared on pulmonary artery imaging. Ten male and thirteen female healthy volunteers were recruited in the present study. Each subject underwent non-contrast-enhanced pulmonary MRA. Four protocols were involved in the present study as follows: 3D BFFE with T-SLIP covering vena cava (VC) and right atrium and ventricle (RV), respectively; 3D TRANCE with T-SLIP covering VC and RV, respectively. The SNR were measured at eight ROIs, while CNR were measured at five ROIs. The number of visualized branch and image quality were analyzed by two radiologists. The differences of metrics among different imaging strategies were compared. SNR and CNR were compared between two T-SLIP placement strategies using a paired t-test. The branches number and image quality were compared between two T-SLIP placement strategies using a rank-sum test. The agreement of subjective assessment was conducted using a Kappa test. There were significant differences at all ROIs between TRANCE and BFEE with T-SLIP on RV (all P values <0.01). TRANCE with T-SLIP on RV exhibited a higher CNR at all five ROIs compared with BFFE with T-SLIP on RV. TRANCE with T-SLIP on RV performed better on the number of observed branches and image quality compared with BFFE with T-SLIP on RV. 3D TRANCE with T-SLIP on RV can provide a higher SNR and image quality among four MR protocols, and thus may be a potential non-contrast enhanced technique in the visualization of pulmonary artery.

01 Apr 2025·Tissue and Cell

PCSK9 exacerbates sevoflurane-induced neuroinflammatory response and apoptosis by up-regulating cGAS-STING signal

Article

Author: Si, Yuting ; Su, Tao

BACKGROUNDPostoperative cognitive dysfunction (POCD) is a postoperative complication that can be induced by anaesthesia. PCSK9 has been shown to have a role in neuronal development and apoptosis. However, PCSK9 has not been studied in sevoflurane-induced POCD-related disorders.OBJECTIVETo explore whether PCSK9 can exacerbate sevoflurane-induced neuroinflammatory response and apoptosis by up-regulating cGAS-STING signalling.METHODSA POCD model was constructed by stimulating BV2 microglia with Sevoflurane. CCK8 was used to detect the cell viability, and immunofluorescence was used to observe the expression of microglial activation markers (Iba-1, CD11b) and BDNF to determine the activation of BV2 microglia. Cell proliferation was measured by EDU staining, and apoptosis was analyzed by flow cytometry and western blot. The levels of inflammatory cytokines, ROS, MDA, SOD and CAT were respectively detected by ELISA, DCFH-DA staining, and kits to determine the neuroinflammation and oxidative stress of cells. Mitochondrial ROS, mitochondrial membrane potential, mtDNA and ATP levels were measured to evaluate cellular mitochondrial function.RESULTSTransfection of si-PCSK9 inhibited Sevoflurane-induced microglial activation and restored cellular viability, promoted cell proliferation, inhibited apoptosis and neuroinflammation, decreased ROS and MDA levels in the cells while up-regulating the levels of SOD and CAT, thus inhibiting oxidative stress, restored the mitochondrial membrane potential to normal and decreased mitochondrial ROS and mtDNA levels and increased ATP production, thereby alleviating mitochondrial dysfunction. Moreover, PCSK9 depletion also down-regulated the expression of cGAS and STING to inactivate cGAS-STING signaling. However, cGAS overexpression partially reversed the effects of si-PCSK9.CONCLUSIONPCSK9 exacerbates sevoflurane-induced neuroinflammatory response and apoptosis by upregulating cGAS-STING signaling.

01 Mar 2025·Molecular and Cellular Endocrinology

EDNRB negatively regulates glycolysis to exhibit anti-tumor functions in prostate cancer by cGMP/PKG pathway

Article

Author: Dong, Qiang ; Wang, Shuheng ; Li, Xun ; Liu, Bide ; Li, Jiuzhi

Prostate cancer (PCa) is the most prevalent cancer in men and the leading cause of cancer-related mortality. Recent studies have highlighted the pivotal role of glycolysis in tumor progression. This study aimed to investigate the involvement of the EDNRB gene and its ligand endothelin 3 (EDN3) in glycolysis in PCa and to elucidate its underlying molecular mechanism. Quantitative reverse transcription PCR (RT-qPCR) and methylation-specific PCR (MSP) were used to probe EDNRB expression and methylation in PCa tissues. Cell proliferation and glycolysis in PCa cells were evaluated using Cell Counting Kit-8 (CCK-8), EDU staining, Seahorse assay, and biochemical kits to analyze the effects of EDN3/EDNRB. The underlying molecular mechanism was further explored through Western blotting. The in vivo effect of EDNRB on tumor growth was examined using a xenograft tumor model. Our findings revealed that EDNRB was hypermethylated and downregulated in PCa tissues and cell lines. Overexpression of EDNRB or EDN3 led to reduced cell proliferation and downregulation of glycolytic markers. EDNRB also decreased the extracellular acidification rate (ECAR) baseline and increased the oxygen consumption rate (OCR) baseline, indicating a shift away from glycolysis. Additionally, the anticancer effects of EDNRB or EDN3 was reversed upon inhibition of the cGMP/PKG pathway. In vivo, enhanced EDNRB expression significantly suppressed tumor growth. Therefore, EDNRB or EDN3 possess anticancer potential in PCa, primarily through the regulation of glycolysis via the cGMP/PKG pathway.

100 Deals associated with Xinjiang Autonomous Region People's Hospital

100 Translational Medicine associated with Xinjiang Autonomous Region People's Hospital

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