Anhui Pharmaceutical Technology Industrial Company

To study the pharmacokinetic characteristics of single and multiple oral administrations of guaifenesin extended-release tablets in healthy subjects and to evaluate the effect of food on the absorption of guaifenesin extended-release tablets.

1) To evaluate the effectiveness of compound ferrous sulfate sustained-release tablets in increasing hemoglobin in the treatment of iron deficiency anemia, and the non-inferiority test was established when compared with ferrous sulfate tablets combined with folic acid; 2) In terms of the safety of treating iron deficiency anemia, compared with ferrous sulfate tablets combined with folic acid, the incidence of gastrointestinal adverse reactions was reduced. 3) The effective rate of treating iron deficiency anemia and the level of serum ferritin (SF), as well as the incidence of other adverse reactions.

In healthy volunteer subjects, the methodology establishment and parameter determination of the pharmacokinetic study of single and continuous administration of compound ferrous sulfate sustained-release tablets produced by Hefei Heyuan Pharmaceutical Co., Ltd. were completed, providing a basis for the effectiveness and safety of clinical medication and further guiding clinical medication.