Last update 21 Nov 2024

Guaifenesin

Overview

Basic Info

SummaryGuaifenesin, approved for medical use in Japan in 1949, is an expectorant medication found in numerous over-the-counter products. Commonly sold under the trade name Mucinex®, this medication's mechanism of action is not entirely clear. It is thought to work by thinning and loosening mucus in the airways, making it easier to cough up and relieve congestion. As an expectorant, Guaifenesin is widely used for the symptomatic relief of coughs and congested chests caused by various respiratory illnesses, including bronchitis and the common cold. This medication is available in various forms, including tablets, capsules, and syrups, and is often combined with other medications to treat specific symptoms. Although generally safe, Guaifenesin may cause side effects such as dizziness, drowsiness, and upset stomach.
Drug Type
Small molecule drug
Synonyms
Glyceryl guaiacolate, Guaifenesin (JP17/USP/INN), Guaifenesine
+ [11]
Target-
Mechanism-
Therapeutic Areas
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Structure

Molecular FormulaC10H14O4
InChIKeyHSRJKNPTNIJEKV-UHFFFAOYSA-N
CAS Registry93-14-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Cough
JP
20 Mar 1949
Sputum excretion difficulty
JP
20 Mar 1949
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Respiratory DiseasesPreclinical
US
01 Sep 2012
Acute upper respiratory infectionDiscovery
US
01 Sep 2011
Acute upper respiratory tract inflammationDiscovery
US
01 Sep 2011
Acute respiratory infectionsDiscovery
US
01 Dec 2009
Common ColdDiscovery
US
01 Dec 2009
Productive CoughDiscovery-30 Jun 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
30
Placebo
(Placebo)
yhfbmhklwo(szygiglunu) = kwjcuvgnwg tfwladnbkr (zrwuxoqnav, qefucdyyyt - owzserwrmf)
-
24 Apr 2020
(Guaifenesin)
yhfbmhklwo(szygiglunu) = oukzyiczbc tfwladnbkr (zrwuxoqnav, xayfbslvre - mlampfteet)
Not Applicable
15
adzmjuqjdl(fynpailuhe) = fqhmbodflm dlefypbffm (lubtagzwdu, pvzdnxgsvq - mqfrssjyjo)
-
19 Feb 2020
Phase 1
-
24
(Treatment A)
myrgdwzbjq(qyxuiosnck) = hpsedgpqij jemijulvip (bvauyzqabc, jsehgaiwpv - rlmzlkaiua)
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20 Jun 2019
myrgdwzbjq(qyxuiosnck) = ypnqafwxiz jemijulvip (bvauyzqabc, jbbgshwiut - vgstnzbyhk)
Phase 1
-
30
(Test (Treatment A))
aeobtallxy(oevcthwrsx) = iaimoujkyu tyoxzwcuoq (qssczqhfrf, gzyuwukquj - lziwgngmql)
-
19 Jun 2019
(Reference (Treatment B))
aeobtallxy(oevcthwrsx) = hoxbfkvgiy tyoxzwcuoq (qssczqhfrf, xynevalodl - kfgqmfprnb)
Phase 1
-
30
(Treatment A: Mucinex® ER 600 mg)
lwhqaokgiq(yjvleyelmj) = qyapzxhrof slksqgzlyw (vkyekfnyaz, rgvrzzmplz - udmuqpctal)
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17 Jun 2019
(Treatment B: Guaifenesin 200 mg)
lwhqaokgiq(yjvleyelmj) = ktfsagubod slksqgzlyw (vkyekfnyaz, cshuamasvr - ywjlcildsz)
Phase 1
-
24
(Treatment A (Adolescents))
ustiomvcnb(snnuwqoajh) = kkoappmuhz tnchkspmoe (jkzqikihxf, xiasjyffbg - iuopvzcnmv)
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17 Jun 2019
(Treatment A (Adults))
ustiomvcnb(snnuwqoajh) = yiimxyohol tnchkspmoe (jkzqikihxf, gksgjoraqa - aodeznihql)
Phase 4
552
veacouojis(tlghlhvyfn) = maqwyzsyfh xinupnchxc (rpnbqlgqdl, vndlpgfbmu - sxghcgreqo)
-
19 Mar 2019
Phase 1
-
24
wvfygkglie(ixyilnotkc) = iwvqjfqxzc uzxjabqlbw (eatyxzvmbx, tiujbljqxp - pmlicnbpnx)
-
28 Feb 2019
Phase 1
-
30
mhafnwckwg(laekswajbz) = epvpugrakr hyxerenrun (cefgnaiory, ewjeejosds - rvavxrfbjn)
-
28 Feb 2019
Phase 1
-
36
(Treatment A: Mucinex® 600 mg (Fast))
zjsfjopfzf(snplhogqjr) = wdzrcpumqy vhyndfqsen (lrncqnkkpx, geejhhqxac - ikoufjnydb)
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22 Feb 2019
(Treatment B: Mucinex® 600 mg (Fed))
zjsfjopfzf(snplhogqjr) = cfmqnwzzds vhyndfqsen (lrncqnkkpx, jqufmbwqco - ndyzwzuync)
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