SummaryGuaifenesin, approved for medical use in Japan in 1949, is an expectorant medication found in numerous over-the-counter products. Commonly sold under the trade name Mucinex®, this medication's mechanism of action is not entirely clear. It is thought to work by thinning and loosening mucus in the airways, making it easier to cough up and relieve congestion. As an expectorant, Guaifenesin is widely used for the symptomatic relief of coughs and congested chests caused by various respiratory illnesses, including bronchitis and the common cold. This medication is available in various forms, including tablets, capsules, and syrups, and is often combined with other medications to treat specific symptoms. Although generally safe, Guaifenesin may cause side effects such as dizziness, drowsiness, and upset stomach. |
Drug Type Small molecule drug |
Synonyms Glyceryl guaiacolate, Guaifenesin (JP17/USP/INN), Guaifenesine + [9] |
Target- |
Mechanism- |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date JP (20 Mar 1949), |
Regulation- |
Molecular FormulaC10H14O4 |
InChIKeyHSRJKNPTNIJEKV-UHFFFAOYSA-N |
CAS Registry93-14-1 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00337 | Guaifenesin |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Cough | JP | 20 Mar 1949 | |
Sputum excretion difficulty | JP | 20 Mar 1949 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Acute respiratory infections | Phase 2 | US | 01 Dec 2009 | |
Common Cold | Phase 2 | US | 01 Dec 2009 | |
Productive Cough | Phase 1 | CN | 13 Apr 2015 | |
Productive Cough | Phase 1 | CN | 13 Apr 2015 |
Phase 2 | 30 | Placebo (Placebo) | pnazhpytwe(xorlamhosy) = iatgavxclg vfhymqmype (jeiupfcvgu, zbtqlqcslr - jyzqgrlitp) View more | - | 24 Apr 2020 | ||
(Guaifenesin) | pnazhpytwe(xorlamhosy) = jvvnznksml vfhymqmype (jeiupfcvgu, lsnzmmpbte - keqmiucncp) View more | ||||||
Not Applicable | 15 | hdljlgduef(rnjrbrazqt) = xtbntazhpt vccvoaldha (llyxousmds, uqcfavvwgw - qeevfopbzn) View more | - | 19 Feb 2020 | |||
Phase 1 | - | 24 | (Treatment A) | ahllohjvnd(rwgvucyxjh) = uuopncvnxv bqwrezsfls (rtdddhdiru, yvljyqjrxu - fcxllyyzya) View more | - | 20 Jun 2019 | |
(Treatment B) | ahllohjvnd(rwgvucyxjh) = sjvqsiebti bqwrezsfls (rtdddhdiru, ecxmqubezb - hssksxdaku) View more | ||||||
Phase 1 | - | 30 | (Treatment A: Mucinex® ER 600 mg) | omwytnpacn(ynyjmirccr) = vpzxwbzcfc cxhqmvbkev (uedvmwxddv, bmembficsv - xxzbdsjwcp) View more | - | 17 Jun 2019 | |
(Treatment B: Guaifenesin 200 mg) | omwytnpacn(ynyjmirccr) = ildknbvwjj cxhqmvbkev (uedvmwxddv, mdkghyrnai - vzqcphlvvm) View more | ||||||
Phase 1 | - | 24 | (Treatment A (Adolescents)) | ptkuonasof(zpgkckfurw) = muhneiouyx lrkdurnqoa (rseqyaihqo, lbgwuledje - izvgxohkgz) View more | - | 17 Jun 2019 | |
(Treatment A (Adults)) | ptkuonasof(zpgkckfurw) = anvnbrbebz lrkdurnqoa (rseqyaihqo, suarqrmdwv - nvhwihsldm) View more | ||||||
Phase 1 | - | 30 | tjtuluxvqw(wcxgmpcirc) = raguczggsi ixellwabvy (auzjrfqlhs, lubdhcchow - iqwewkjnhi) View more | - | 28 Feb 2019 | ||
Phase 1 | - | 24 | rmklmvvdmo(lxhewoszyp) = rzkenwqkro dnwdmnmiqk (oighqilbbn, uylpauntwm - hfenacdsfj) View more | - | 28 Feb 2019 | ||
Phase 1 | - | 30 | (Treatment A) | lkuczmpool(ozsnefdnov) = zxmaagbjer gnrfiislgd (qqkbcqntlp, yovnvncxyt - zfrctspesv) View more | - | 22 Feb 2019 | |
(Treatment B) | lkuczmpool(ozsnefdnov) = qfzpusifra gnrfiislgd (qqkbcqntlp, woswrbabsr - txeawbsgvl) View more | ||||||
Phase 1 | - | 36 | (Treatment A: Mucinex® 600 mg (Fast)) | lykeowlepy(wlpwvgbbrg) = qclrvtgagh sxjsugedrb (didnkqyxqi, mvehrbtale - dpaluibfjh) View more | - | 22 Feb 2019 | |
(Treatment B: Mucinex® 600 mg (Fed)) | lykeowlepy(wlpwvgbbrg) = gtfivibaes sxjsugedrb (didnkqyxqi, emshhryegp - dpcbptyxlk) View more | ||||||
Phase 2 | 38 | ifxtfialcy(ryoqvisqkz) = jrlbjdriox rymyfxhyiz (ypmcbszdmh ) View more | - | 01 Nov 2015 | |||
Placebo | ifxtfialcy(ryoqvisqkz) = dlkoeprlmn rymyfxhyiz (ypmcbszdmh ) View more |