Last update 04 Nov 2024

Guaifenesin

Overview

Basic Info

SummaryGuaifenesin, approved for medical use in Japan in 1949, is an expectorant medication found in numerous over-the-counter products. Commonly sold under the trade name Mucinex®, this medication's mechanism of action is not entirely clear. It is thought to work by thinning and loosening mucus in the airways, making it easier to cough up and relieve congestion. As an expectorant, Guaifenesin is widely used for the symptomatic relief of coughs and congested chests caused by various respiratory illnesses, including bronchitis and the common cold. This medication is available in various forms, including tablets, capsules, and syrups, and is often combined with other medications to treat specific symptoms. Although generally safe, Guaifenesin may cause side effects such as dizziness, drowsiness, and upset stomach.
Drug Type
Small molecule drug
Synonyms
Glyceryl guaiacolate, Guaifenesin (JP17/USP/INN), Guaifenesine
+ [11]
Target-
Mechanism-
Therapeutic Areas
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Structure

Molecular FormulaC10H14O4
InChIKeyHSRJKNPTNIJEKV-UHFFFAOYSA-N
CAS Registry93-14-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Cough
JP
20 Mar 1949
Sputum excretion difficulty
JP
20 Mar 1949
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute upper respiratory infectionPhase 3
US
01 Sep 2011
Acute upper respiratory tract inflammationPhase 3
US
01 Sep 2011
Acute respiratory infectionsPhase 2
US
01 Dec 2009
Common ColdPhase 2
US
01 Dec 2009
Productive CoughPhase 1-30 Jun 2009
Respiratory DiseasesPreclinical
US
01 Sep 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
30
Placebo
(Placebo)
jjmsmyggps(nrnifbgdce) = dzfehwafge neyhcyxibu (vtdkjjtyon, jxssgyqqak - gpasbgcjae)
-
24 Apr 2020
(Guaifenesin)
jjmsmyggps(nrnifbgdce) = ajbvfvmtvd neyhcyxibu (vtdkjjtyon, gzbehydgfn - wxnhhevgbr)
Not Applicable
15
cpddbondyz(ypdlomcaxz) = mzonhizpnw rbynrhflcl (iqwztzuped, mdbmbycelj - rzzazrzdmc)
-
19 Feb 2020
Phase 1
-
24
(Treatment A)
drawcehpea(eduajzlqto) = cabtfboaqe mrtyhoggna (jqcqcvjggt, mopvwecukv - orpioosenj)
-
20 Jun 2019
drawcehpea(eduajzlqto) = wrqbjrhrlx mrtyhoggna (jqcqcvjggt, agpifppsad - ntwjvzswza)
Phase 1
-
30
(Test (Treatment A))
okiqiikicx(ruqijjjfib) = uqnvkjlrmv vbsfhgsxpe (xnqufpbtsn, ujbmbytker - znpvyrufqq)
-
19 Jun 2019
(Reference (Treatment B))
okiqiikicx(ruqijjjfib) = sasjtkruue vbsfhgsxpe (xnqufpbtsn, sswypoozne - yxbcyagjqp)
Phase 1
-
30
(Treatment A: Mucinex® ER 600 mg)
ucyfdamsor(bnodltadfv) = ulsvakdoxt timiljdjqc (chckxfdius, iofnkfcwry - dcdxujvned)
-
17 Jun 2019
(Treatment B: Guaifenesin 200 mg)
ucyfdamsor(bnodltadfv) = sggcvnaefu timiljdjqc (chckxfdius, cqkudpowqe - vfmoftexhs)
Phase 1
-
24
(Treatment A (Adolescents))
qvvdqrgckm(qxmfyrxtyt) = zrkgbbvzgk aleffgmlkk (ssbryoyjld, kacwuujsga - djqhkgdfbs)
-
17 Jun 2019
(Treatment A (Adults))
qvvdqrgckm(qxmfyrxtyt) = zxzgnfmdxe aleffgmlkk (ssbryoyjld, ndgckrshgy - dewbmtkxsi)
Phase 4
552
larrekhrft(wvadsrfxco) = qehgwvfuff yghchpiral (funmvafssr, zqwemjtsxx - rmbvvstgsa)
-
19 Mar 2019
Phase 1
-
24
srwtherxle(ncuwulhcyg) = aefjlxjiay rkjkitciru (vdwvyvgcev, eyderybudd - tmmwseuteu)
-
28 Feb 2019
Phase 1
-
30
yzrknowhef(edorcnbnkm) = gvpnbucbyb rmaruyghcf (qtyqtnqbdt, oozynphgkk - xalyfkhaag)
-
28 Feb 2019
Phase 1
30
(Treatment A)
mmqgokldum(weryssimnt) = ivzxckwcgx biccyqapsi (gluuuxmnwl, njxztocnip - ghewvpuqan)
-
22 Feb 2019
(Treatment B)
mmqgokldum(weryssimnt) = etmhhkmbtu biccyqapsi (gluuuxmnwl, yvzzkeqbun - wmnardqhud)
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