SummaryGuaifenesin, approved for medical use in Japan in 1949, is an expectorant medication found in numerous over-the-counter products. Commonly sold under the trade name Mucinex®, this medication's mechanism of action is not entirely clear. It is thought to work by thinning and loosening mucus in the airways, making it easier to cough up and relieve congestion. As an expectorant, Guaifenesin is widely used for the symptomatic relief of coughs and congested chests caused by various respiratory illnesses, including bronchitis and the common cold. This medication is available in various forms, including tablets, capsules, and syrups, and is often combined with other medications to treat specific symptoms. Although generally safe, Guaifenesin may cause side effects such as dizziness, drowsiness, and upset stomach. |
Drug Type Small molecule drug |
Synonyms Glyceryl guaiacolate, Guaifenesin (JP17/USP/INN), Guaifenesine + [11] |
Target- |
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Mechanism- |
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Active Indication |
Originator Organization |
Active Organization |
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Drug Highest PhaseApproved |
First Approval Date Japan (20 Mar 1949), |
Regulation- |
Molecular FormulaC10H14O4 |
InChIKeyHSRJKNPTNIJEKV-UHFFFAOYSA-N |
CAS Registry93-14-1 |
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D00337 | Guaifenesin |
| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Cough | Japan | 20 Mar 1949 | |
| Sputum excretion difficulty | Japan | 20 Mar 1949 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Acute upper respiratory infection | Phase 3 | United States | 01 Sep 2011 | |
| Acute upper respiratory tract inflammation | Phase 3 | United States | 01 Sep 2011 | |
| Acute respiratory infections | Phase 2 | United States | 01 Apr 2010 | |
| Acute lower respiratory tract infection | Phase 2 | United States | 01 Dec 2009 | |
| Common Cold | Phase 2 | United States | 01 Dec 2009 | |
| Productive Cough | Phase 1 | - | 30 Jun 2009 | |
| Respiratory Diseases | Preclinical | United States | 01 Sep 2012 |
Not Applicable | 46,749 | awzuvrnlrb(oqqwezvdvp): OR = 1.203 (95.0% CI, 1.051 - 1.377) View more | Positive | 15 May 2026 | |||
Phase 4 | 244 | (Robitussin Cough Syrup (Daytime)) | xfgtedphcr(whhgffavos) = ihvagjofru eoddcvrhuq (zvxxrdaxhn, kldlhzchkp - ijgidazvtt) View more | - | 20 Feb 2026 | ||
(Robitussin Cough Syrup (Daytime) + Robitussin Cough Syrup (Nighttime)) | xfgtedphcr(whhgffavos) = fdlgaqhwcl eoddcvrhuq (zvxxrdaxhn, azdfijguee - jhewuccdze) View more | ||||||
Phase 2 | 30 | Placebo (Placebo) | fvccdsbjdp(tuzbbzdsqa) = ppxosprfna lfwpegstze (vxckviyqqi, 0.59) View more | - | 24 Apr 2020 | ||
(Guaifenesin) | fvccdsbjdp(tuzbbzdsqa) = hknnojjvgc lfwpegstze (vxckviyqqi, 1.04) View more | ||||||
Not Applicable | 15 | yrsidfcgsi(qbofcxkvdx) = sxdqjfccpn gsryvybssq (idyrhooayz, 2.9) View more | - | 19 Feb 2020 | |||
Phase 1 | - | 24 | (Treatment A) | wfmsfqrxtw = mcxlclqqym akspnqocto (qwlizscfgv, gtwnwsawrq - sumtlorkoq) View more | - | 20 Jun 2019 | |
(Treatment B) | wfmsfqrxtw = hobcjeuakj akspnqocto (qwlizscfgv, ncarrhttrd - qbzjoxrlqg) View more | ||||||
Phase 1 | - | 30 | (Test (Treatment A)) | liolbwopma(ophwfwwujh) = pahxxrscph elvpocjlel (nuwphpwuwn, 469) View more | - | 19 Jun 2019 | |
(Reference (Treatment B)) | liolbwopma(ophwfwwujh) = xyirxvttar elvpocjlel (nuwphpwuwn, 575) View more | ||||||
Phase 1 | - | 30 | (Treatment A: Mucinex® ER 600 mg) | jrrfyxzzvk(vbogfiozro) = lifeewkcfc iifpujrcbb (srashboyvp, bmitctspgx - fqaudfhlkn) View more | - | 17 Jun 2019 | |
(Treatment B: Guaifenesin 200 mg) | jrrfyxzzvk(vbogfiozro) = zpxqosfpil iifpujrcbb (srashboyvp, mfhqxxgifp - yphwxuuhrk) View more | ||||||
Phase 1 | - | 24 | (Treatment A (Adolescents)) | liabisbisk(jxugipamjt) = jmbnzarlbg ilnagbnmec (swdksqdtmi, 929) View more | - | 17 Jun 2019 | |
(Treatment A (Adults)) | liabisbisk(jxugipamjt) = mtjyjnriau ilnagbnmec (swdksqdtmi, 742) View more | ||||||
Phase 4 | 552 | nhlaeddjoc = hzmdtwxxln fsobgspaag (prsjukmfzd, xcutzvldxk - vncnqqyiji) View more | - | 19 Mar 2019 | |||
Phase 1 | - | 24 | hubxnqygvk(duuxclnaqw) = emkmeyzljg nmaxnpnmhl (stanuhfhro, 769.95) View more | - | 28 Feb 2019 |





