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Ortho-functionalization of pillar[n]arenes has been a formidable challenge, partially due to the fragility of their macrocyclic skeletons. In this concise report, we describe a facile synthetic method for monoarylation/alkylation at the position ortho to the oxime functionality in pillar[4]arene[1]benzoquinone monoxime (1) via addition of Grignard reagents. The described method enables the creation of various mono-ortho-alkyl/aryl-substituted pillar[5]arene derivatives that were previously inaccessible.

01 Feb 2020·Supramolecular Chemistry

A facile method for the synthesis of free-standing pillar[5]arene-based two-dimensional covalent organic monolayers in solution

Author: Wen, Ke ; Liu, Yahu A. ; Qiang, Hui ; Chen, Tao ; Jia, Xue-Shun ; Jiang, Biao ; Hu, Wei-Bo

This report describes a facile method by which, without using any surface-assisted growth or pre-organization, free-standing two-dimensional (2D) covalent organic monolayers () were synthesized through condensation reactions of planar tri-aldehydes with A1/A2-diamino-substituted pillar[5]arene ().In the as-formed monolayers (and), the tubular pentagonal pillar[5]arene units positioned out of the 2D polymer planes suppress efficiently the interlayer p-p stacking interactions.Both nd can be transferred onto solid surfaces for further characterization and were found to possess unusual fluorescence up-conversion property.

11 Feb 2019·Chemistry – A European JournalQ2 · CHEMISTRY

A Diaminopillar[5]arene‐Based Macrobicyclic Molecule: Synthesis, Characterization and A Lock–Key Story

Q2 · CHEMISTRY

Article

Author: Wen, Ke ; Zhao, Xiao-Li ; Liu, Yahu A ; Wang, Zhuo ; Hu, Wei-Bo ; Jiang, Biao ; Li, Jiu-Sheng

AbstractA new macrobicyclic molecule (BC‐DAP5), consisting of a diaminopillar[5]arene cavity and a fused ring, was successfully constructed using a Grubbs metathesis reaction. Further studies indicated that BC‐DAP5 possessed a unique molecular behavior, showing a response to acid/base stimuli. In BC‐DAP5, protons (acid) acted as a lock, locking the fused ring out of the cavity (pillar[5]arene), and a base served as the key, making the fused ring switch in or out freely. Reversible control of the molecular behavior was achieved simply by adding acid and base alternately.

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Pipeline

Pipeline Snapshot as of 14 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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