Delving into the Latest Updates on Guangdong Medical University with Synapse

Overview

Tags

Neoplasms

Respiratory Diseases

Cardiovascular Diseases

Small molecule drug

Recombinant polypeptide

Monoclonal antibody

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	4

Top 5 Drug Type	Count

Small molecule drug	2
CAR-NK	1
Monoclonal antibody	1
Polyclonal antibody	1
Recombinant polypeptide	1

Top 5 Target	Count

PDL1(Programmed death-ligand 1)	1
ERK1 x ERK2	1
TGM3(transglutaminase 3)	1
GSDMD(gasdermin D)	1
SF3B1(Splicing factor 3B subunit 1)	1

The most common malignant tumor in women is breast cancer, so >90 % of patients′ deaths are closely related to the strong invasive and metastatic ability of breast cancer.It is of critical significance to detect, diagnose, and treat breast cancer promptly through the close monitoring of breast cancer markers.A variety of cancer markers are available to reflect the progression of breast cancer.Still, most existing cancer assays have low selectivity, poor sensitivity, complicated procedures, require specialized instruments and technicians, and are time-consuming.Herein, we summarize the applications of metal-organic frameworks (MOFs) for breast cancer detection in electrochem. sensors, fluorescent sensors, and imaging sensitization and discuss in depth the relationship between the structures and sensing mechanisms in each sensor.Finally, some pressing issues in breast cancer markers are summarized here.In addition, we have highlighted the prospects for future progress, which may provide a new way of thinking for monitoring individualized treatment for breast cancer patients.

01 Jan 2025·Colloids and Surfaces B: Biointerfaces

A novel m-xylylene-diamine/glucose based-supramolecular eutectogels with tissue clearing for three dimensional histological imaging

Article

Author: Qin, Ruixiu ; Huang, Peixin ; Lin, Changmei ; Li, Qian ; Fang, Fang ; Quan, Weiyan ; Wu, Kefeng ; Ouyang, Qianqian ; Liao, Jing ; Zhu, Yuzhen ; Xu, Qingbao

Hydrogel-based tissue clearing technologies have shown significant promise for deep-tissue imaging and subcellular-level optical 3D reconstruction of whole organs. This study proposes a novel approach utilizing a deep eutectic solvent (DES) formulated with glucose and m-xylylene-diamine (MXDA) to create a highly efficient tissue-clearing hydrogel system named the passive hydrogel clearing system (PHCS). PHCS achieved efficient tissue clearing through a single-step tissue gelation process. The resulting hydrogel-tissue complex exhibited thermoreversible properties, transitioning into a sol state upon heating and vice versa upon cooling. Notably, PHCS enabled media embedding, facilitating immunofluorescence histopathology. Additionally, the system demonstrated compatibility with various fluorescent probes, particularly lipophilic dyes. Our study successfully employed PHCS for the reconstruction of vascular structures within the intestine, enabling the generation of a 3D pathology model. These findings suggest that PHCS is a promising novel method for fabricating hydrogels for tissue clearing and holds great potential for application as a mounting medium for morphological imaging.

01 Jan 2025·Phytochemistry

Cynbungenins A-K, structurally diverse steroids with cytotoxic activity from the roots of Cynanchum bungei Decne

Article

Author: Peng, Xiao-Fu ; Liu, Ming-Shang ; Luo, Hui ; Yang, Xue-Mei ; Feng, Wan-Bi ; Li, Ting-Ting ; Huang, Yong-Mei ; Yuan, Wei-Bin ; Li, Xiao-San ; Luo, Yu-Hao

Chemical investigation of the acid hydrolysate of Cynanchum bungei roots led to the isolation of eleven undescribed steroids, namely cynbungenins A-K (1-11), and seven previously described analogues (12-18). The complete structures of these compounds were elucidated using the comprehensive spectroscopic analyses and reference data. Structurally, compounds 1 and 2 represent the first example of androstane-type steroids found in the Cynanchum plants, and compounds 3-6 and 12 are characterized as pregnane-type steroids with a rare 8,14-seco-steroid core. In the cytotoxic activity assay, compound 16 displayed the strongest cytotoxic effect against MCF-7, HCT-116, HeLa, and HepG2 cancer cell lines, with IC₅₀ values of 9.98-16.42 μM, and further research indicated that it induced both apoptosis and cell cycle arrest in the G0/G1 phase in a dose-dependent manner toward HepG2 cells.

100 Deals associated with Guangdong Medical University

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100 Translational Medicine associated with Guangdong Medical University

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Pipeline

Pipeline Snapshot as of 23 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

3

Preclinical

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

PD-L1 Targeted CAR-NK (IMCB) ( PDL1 )	Ischemia More	Preclinical
Laxiflorin B-4 ( ERK1 x ERK2 )	Non-Small Cell Lung Cancer More	Preclinical
Fucosterol derivatives	Fibrosis More	Preclinical
CN116515786 ( TGM3 )	Neoplasms More	Discovery
CN116425856 ( SF3B1 )	Neoplasms More	Discovery