Delving into the Latest Updates on Northwest Minzu University with Synapse

Overview

Tags

Respiratory Diseases

Infectious Diseases

Prophylactic vaccine

Multivalent vaccine

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

No Data

Disease Domain	Count

Infectious Diseases	2

Top 5 Drug Type	Count

Multivalent vaccine	2
Prophylactic vaccine	2

主要目的：四价流感病毒裂解疫苗（MDCK细胞）在6月龄及以上健康人群中接种的安全性。次要目的：四价流感病毒裂解疫苗（MDCK细胞）在6月龄及以上健康人群中接种的免疫原性。探索性目的：探索3~8岁人群以2种免疫程序接种四价流感病毒裂解疫苗（MDCK细胞）的免疫原性。

[Translation]

Primary objective: Safety of quadrivalent influenza virus split vaccine (MDCK cells) in healthy people aged 6 months and above. Secondary objective: Immunogenicity of quadrivalent influenza virus split vaccine (MDCK cells) in healthy people aged 6 months and above. Exploratory objective: Explore the immunogenicity of quadrivalent influenza virus split vaccine (MDCK cells) in 2 immunization schedules in people aged 3 to 8 years.

Start Date30 Mar 2024

Sponsor / Collaborator

Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd.

[+2]

CTR20233159

/ Active, not recruitingPhase 3

评价四价流感病毒裂解疫苗（MDCK细胞）接种于3周岁及以上人群的免疫原性和安全性的随机、双盲、同类疫苗对照Ⅲ期临床试验

[Translation] A randomized, double-blind, similar vaccine-controlled phase III clinical trial to evaluate the immunogenicity and safety of quadrivalent influenza virus split vaccine (MDCK cells) in people aged 3 years and above

评价四价流感病毒裂解疫苗（MDCK细胞）接种于3岁及以上人群免疫原性和安全性的随机、双盲、同类疫苗对照的Ⅲ期临床试验

[Translation]

A randomized, double-blind, similar vaccine-controlled phase III clinical trial to evaluate the immunogenicity and safety of quadrivalent influenza virus split vaccine (MDCK cells) in people aged 3 years and above

Start Date30 Sep 2023

Sponsor / Collaborator

Lanzhou Bailing Biotechnology Co., Ltd.

[+2]

CTR20222735

/ Active, not recruitingPhase 1

评价四价流感病毒裂解疫苗（MDCK细胞）接种于3岁及以上人群安全性的单中心、盲法、阳性疫苗和安慰剂对照的Ⅰ期临床试验

[Translation] A single-center, blinded, positive vaccine and placebo-controlled phase I clinical trial to evaluate the safety of quadrivalent influenza virus split vaccine (MDCK cells) in people aged 3 years and above

评价四价流感裂解疫苗（MDCK细胞）在3岁及以上人群中的安全性，并初步评价该苗的免疫原性。

[Translation]

To evaluate the safety of quadrivalent influenza split vaccine (MDCK cells) in people aged 3 years and above and to preliminarily evaluate the immunogenicity of the vaccine.

Start Date21 Oct 2022

Sponsor / Collaborator

Lanzhou Bailing Biotechnology Co., Ltd.

[+2]

100 Clinical Results associated with Northwest Minzu University

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0 Patents (Medical) associated with Northwest Minzu University

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4,211

Literatures (Medical) associated with Northwest Minzu University

31 Dec 2025·Renal Failure

Diastolic dysfunction among patients in end-stage kidney disease: musings on zinc, blood pressure and fetuin-A

Article

Author: Zhang, Lijing ; Ma, Yanqing ; Zhao, Yu ; Guo, Zhong ; Jin, Long

31 Dec 2025·Cell Adhesion & Migration

N-Acetylcysteine relieving hydrogen peroxide-induced damage in granulosa cells of sheep

Article

Author: Zhang, Taojie ; Zhao, Zhijie ; Zhao, Bingzhu ; Li, Yang ; Yang, Chongfa ; Yang, Yahua ; Huo, Shengdong ; Wang, Jine ; Ding, Xiaona ; Chen, Hao ; Yingpai, Zhaxi

Sheep ovarian granulosa cells (GCs) play a unique role in the ovary. Damage to GCs can affect the normal development of oocytes. The oxidative stress model was constructed by H₂O₂to study the biological changes. Specifically, pathological characteristic was assessed by immunohistochemistry (IHC), while signaling pathway was studied using western blot, quantitative RT-PCR, and immunofluorescence. Theresults showed that the oxidative damage model was successfully constructed by 200 μmol/LH₂O₂ for 12 h. NAC can protect the proliferation of GCs under H₂O₂-induced oxidative stress and reduce apoptosis. It can also promote the secretion of E₂ and P₄ by GCs and reduce the inflammatory response of GCs. NAC can enhance the expression of NRF2, PI3K and Akt. These findings suggest that NAC alleviates H₂O₂-induced oxidative stress injury through NRF2/PI3K/AKT signaling pathways. Provide ideas for studying the poor quality of mammalian oocytes.

01 Aug 2025·Separation and Purification Technology

Regulating the electronic structure of BiOBr by Cu-doping to promote efficient photocatalytic nitrogen fixation reaction

Author: Su, Xiaoping ; Zhang, Ping ; Yu, Yongchong ; Tuerhong, Reyila ; Han, Lijuan ; Chai, Keyi ; Zhao, Lianbiao ; Du, Xinyu

Element doping is critical in regulating the electronic structure to enhance N₂ adsorption, opening up new possibilities for achieving highly efficient photocatalytic nitrogen reduction reactions (pNRR).In this study, we successfully prepared Cu-doped BiOBr (Cu-BiOBr) using a simple solvothermal method.D. Functional Theory (DFT) calculations and exptl. investigations were employed to explore how Cu doping influences the performance of pNRR over BiOBr.The DFT anal. indicates that Cu doping alters the electronic structure, lowers the energy barrier of the reaction, and narrows the bandgap.This electronic structure adjustment leads to the remarkable NH₃ production rate of 466.3 μmol·g^-1_cat·h^-1 without the need for sacrificial agents in the 2 % Cu-BiOBr sample.In addition, based on the findings of DFT and in-situ FTIR, a detailed mechanism for the adsorption/activation and hydrogenation reaction of N ≃ N bonds on Cu-BiOBr was proposed.This research introduces a prospective way for designing transition metal-doped BiOBr catalysts with regulated electronic structures for pNNR, which has significant implications for advancing other material systems.

100 Deals associated with Northwest Minzu University

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100 Translational Medicine associated with Northwest Minzu University

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Pipeline

Pipeline Snapshot as of 17 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Phase 1 Clinical

1

Phase 3 Clinical

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Tetravalent influenza vaccine(Wuhan Institute of Biological Products Co., Ltd.)	Influenza, Human More	Phase 3
Quadrivalent influenza vaccine(Zhejiang Tianyuan Bio-Pharmaceutical)	Influenza, Human More	Phase 1