Trigone Pharma Ltd. is a privately-owned corporation headquartered in Raanana, Israel, which specializes in the production of pharmaceuticals. The company's primary objective is to enhance the quality of life for patients with bladder diseases that have not yet been adequately addressed by current medical treatments. By utilizing their exclusive technology, Trigone Pharma is developing groundbreaking therapies for a range of diseases that impact millions of individuals worldwide. Their lead product, TRG-100, is a novel, long-acting treatment that combines two medications for the intravesical treatment of IC/BPS, a chronic bladder condition characterized by severe pain. The company's pipeline also includes potential treatments for overactive bladder, renal colic, and bladder cancer.

Disease Domain	Count

Neoplasms	2
Endocrinology and Metabolic Disease	1
Hemic and Lymphatic Diseases	1
Immune System Diseases	1

Top 5 Drug Type	Count

Small molecule drug	2
Chemical drugs	1

Top 5 Target	Count

Ribonucleotide reductase	1
DNA x PSMA x Ribonucleotide reductase	1

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Pipeline

Pipeline Snapshot as of 23 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

Phase 2 Clinical

Other

Current Projects

Drug(Targets)	Indications	Global Highest Phase

Gemcitabine Hydrochloride/Docetaxel ( DNA x PSMA x Ribonucleotide reductase )	Non-Muscle Invasive Bladder Neoplasms More	Phase 2
Gemcitabine ( Ribonucleotide reductase )	Bladder Cancer More	Preclinical
TRG-120	Urinary Bladder, Overactive More	Preclinical
Lidocaine/Oxybutynin ( M1 receptor x M2 receptor x M3 receptor )	Bladder pain More	Pending

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