The in vitro dissolution rate and plasma concentration of indomethacin (I) [53-86-1] from plasters (type III) were 70.6% of the initial drug amount for 6 h and 10.4 μg/mL 4 h after application, resp., and higher than those from plasters type I or type II. For preparing type III plasters, I was mixed with propylene glycol and urea and printed onto an adhesive surface of a plaster base in a checkered pattern. The other plasters were prepared by compounding I with the plaster base (Type I) or by spreading I onto the adhesive surface of the plaster base without side space (type II). The percutaneous absorption of I was studied after applying I to rat abdomen. The dissolution of I from plasters followed the order: type III > type II > type I.