[Translation] Bridging study and food effect study in Chinese healthy subjects: Evaluation of the safety, tolerability and pharmacokinetic characteristics of KBP-5074
主要目的:评价单次口服给药后,KBP-5074的安全性和耐受性以及药代动力学(PK)特征。 次要目的:评价食物对KBP-5074的PK的影响,探索性评价药代/药效动力学(PK/PD)(血浆醛固酮)关系。
[Translation] Primary objective: To evaluate the safety, tolerability and pharmacokinetic (PK) characteristics of KBP-5074 after a single oral administration. Secondary objective: To evaluate the effect of food on the PK of KBP-5074 and to explore the pharmacokinetic/pharmacodynamic (PK/PD) (plasma aldosterone) relationship.