Gansu College of Traditional Chinese Medicine

Frailty is prevalent among the elderly population and can lead to multiple negative health consequences.

This study compares the effects of digital interventions versus either non-digital interventions with the same content or routine treatment/care alone (or both) on improving physical function and frailty status in older adults, and clarifies the formal advantages and comprehensive benefits of digital interventions.

Systematic review and meta-analysis of randomized controlled trials.

Systematic searches of the PubMed, Embase, Web of Science, CINAHL, PsycINFO, the Cochrane Library, and CNKI for publications archived in the database between its launch and January 16, 2025. The meta-analysis was performed using stata 15.0 and 16.0. We used the 2019 Revised version of the Cochrane risk-of-bias tool (RoB 2.0) to evaluate the study's quality.

23 studies were conducted from 2007 to 2024 in 5 continents that investigated 3426 frail elderly participants were included in the review.The meta-analytic findings indicated superior efficacy in older adults with frailty for digital health interventions over control group on measures of the frailty scores (standardized mean difference (SMD)= -0.42, 95 % confidence intervals (CI) [-0.72, -0.12]; P = 0.006), grip strength (weighted mean difference (WMD)= 1.11, 95 % CI [0.09, 2.14]; P = 0.034), cognitive function (SMD= 0.12, 95 % CI [0.01, 0.24]; P = 0.038), and quality of life (SMD= 0.30, 95 % CI [0.11, 0.50]; P = 0.003). Subgroup analysis stratified by control group type revealed that the digital intervention combined with exercise group significantly improved frailty status (SMD= -0.52, 95 % CI[-0.96, -0.08]; P = 0.020), grip strength (WMD= 1.82, 95 % CI[0.53, 3.12]; P = 0.006), and cognitive function (SMD= 0.20, 95 % CI[0.04, 0.37]; P = 0.015) in elderly patients to a greater extent compared with the usual care group. There were no significant differences between digital health interventions and control groups on any of the remaining 5 comparisons: Timed Up and Go Test (WMD= -0.73, 95 % CI [-1.52, 0.06]; P = 0.07), gait speed (WMD= 0.02, 95 % CI [-0.05, 0.09]; P = 0.55), Short Physical Performance Battery (WMD = -0.17, 95 % CI [-1.14, 0.79]; P = 0.724), Sit-to-Stand Test (WMD = 0.19, 95 % CI [-0.69, 1.07]; P = 0.67), and depression (SMD = -0.21, 95 % CI [-0.47, 0.05]; P = 0.107). Meta-regression analyses revealed that covariates including sex distribution, country of origin, care setting, intervention type, intervention duration, and assessment methodology exhibited no significant moderating effects on grip strength, cognitive function, or quality of life outcomes.

The study results showed that frail elderly individuals who received digital health interventions improved their frailty status, grip strength, cognitive function, and quality of life. Furthermore, compared with the usual care group, the digital exercise intervention group showed superior effects on improving grip strength, frailty status, and cognitive function among frail elderly populations, suggesting that the "digital intervention combined with exercise" model should be prioritized for managing geriatric frailty in clinical practice. Future research should conduct more large-sample, homogeneous, high-quality clinical trials to more accurately verify the effects of core digital modules on frailty and physical function in the elderly.

CRD42024614928 (PROSPERO).

Cervical cancer is the fourth most common and deadly cancer globally. Hypoxia-inducible factor-1α (HIF-1α) plays a key promoter of tumor progression and treatment resistance, making it an important anticancer target. Here, we designed and synthesized a series of novel HIF-1α-targeting PROTAC degraders based on LW-6 and its derivative W-1. Among them, Z12 showed the strongest anti-proliferative and HIF1α degradation activities in HeLa cells. Z12 promoted HIF-1α degradation via the ubiquitin-proteasome pathway by facilitating the formation of a HIF-1α/VHL ternary complex. Furthermore, Z12 inhibited HeLa cell proliferation, migration, and colony formation, induced apoptosis, and reduced p-MEK and p-AKT expression in the MAPK and PI3K/AKT pathways. This work offers a promising strategy for developing HIF1α-PROTAC degraders and treating cervical cancer.