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A Phase Ib/IIa, Dose Escalation, Open-Label Study of Intratumoral CAN1012 Combined With PD-1 in Patients With Unresectable or Metastatic Advanced Solid Tumors
This is a Phase Ia/IIb, open-label, first-in-human, multicenter, single-arm, dose escalation study of intratumoral CAN1012 combined with PD-1 in patients with Unresectable or Metastatic Advanced Solid Tumors who have exhausted options for standard of care therapy.
瘤内注射CAN1012注射液联合特瑞普利单抗在晚期实体瘤患者中的安全性、耐受性及初步有效性的Ib/IIa 期临床试验
[Translation] Phase Ib/IIa clinical trial to evaluate the safety, tolerability and preliminary efficacy of intratumoral CAN1012 injection combined with toripalimab in patients with advanced solid tumors
主要目的:
1) 评估CAN1012注射液联合特瑞普利单抗在晚期实体瘤参与者中的安全性和耐受性;
2) 确定CAN1012注射液联合特瑞普利单抗的最大耐受剂量(MTD)和/或II期推荐剂量(RP2D)。
次要目的:
1) 评估CAN1012注射液联合特瑞普利单抗在晚期实体瘤参与者中的初步有效性;
2) 评估CAN1012注射液联合特瑞普利单抗在晚期实体瘤参与者中的药效动力学(PD)特征。
[Translation] Primary objectives:
1) To evaluate the safety and tolerability of CAN1012 injection combined with toripalimab in participants with advanced solid tumors;
2) To determine the maximum tolerated dose (MTD) and/or recommended phase II dose (RP2D) of CAN1012 injection combined with toripalimab.
Secondary objectives:
1) To evaluate the preliminary efficacy of CAN1012 injection combined with toripalimab in participants with advanced solid tumors;
2) To evaluate the pharmacodynamic (PD) characteristics of CAN1012 injection combined with toripalimab in participants with advanced solid tumors.
A Phase 1, Dose Escalation, Open-Label Study of Intratumoral CAN2109 in Subjects With Unresectable or Metastatic Advanced Solid Tumors.
A phase 1, dose escalation, open-label study of intratumoral CAN2109 in subjects with unstable or metastatic advanced solid tumors or lymphomas.
100 Clinical Results associated with Conway (Guangzhou) Biotechnology Co., Ltd.
0 Patents (Medical) associated with Conway (Guangzhou) Biotechnology Co., Ltd.
100 Deals associated with Conway (Guangzhou) Biotechnology Co., Ltd.
100 Translational Medicine associated with Conway (Guangzhou) Biotechnology Co., Ltd.