Seefunge Pharmaceutical Technology Co., Ltd.

The clinical trial aims to test the effectiveness and safety of two low-dose atropine sulfate eye drops for delaying myopia progression in children and adolescents.
Primary Objective: evaluate the effectiveness of 0.01% and 0.02% atropine sulfate eye drops for 96 weeks compared to placebo in delaying myopia progression in children and adolescents. Secondary Objective: evaluate the safety of two low-concentration atropine sulfate eye drops (0.01%/0.02%) in delaying myopia progression in children and adolescents.
Exploratory Objective:
1. the efficacy and safety of two low-concentration atropine sulfate eye drops (0.01%/0.02%) for 144 weeks.
2. evaluate the rebound effect of two low-concentration atropine sulfate eye drops (0.01%/0.02%) after discontinuation.

主要试验目的：在中国健康受试者中评价单次空腹服用宁夏康亚药业股份有限公司生产的羟苯磺酸钙片0.5g（规格：0.25g/片；受试制剂）和OMpharma S.A.生产的羟苯磺酸钙片500mg（商品名：Doxium；规格：250mg/片；参比制剂）的生物等效性； 次要试验目的：观察受试制剂和参比制剂在健康受试者中的安全性。

主要目的： 评价甲磺酸酚妥拉明滴眼液逆转健康参与者由药物诱导的瞳孔散大的有效性。 次要目的: 评价甲磺酸酚妥拉明滴眼液逆转健康参与者由药物诱导的瞳孔散大的安全性； 评价甲磺酸酚妥拉明滴眼液逆转健康参与者由药物诱导的瞳孔散大的药代动力学（PK）特征。