Delving into the Latest Updates on Liponex, Inc. with Synapse

Overview

A uniquely formulated soy phospholipid is being developed as a potential therapeutic for the treatment and prevention of heart disease. Three phase I and one phase I/II clinical trials have been completed with soy phosphatidylinositol (PI). The compound was shown to be safe in all trials and at doses over 5 g. Clinical studies have also shown early-stage efficacy to suggest that PI is able to raise plasma HDL-cholesterol and apolipoprotein A-I levels, and reduce triglyceride levels in humans. PI directly impacts plasma HDL levels through a MAPK stimulation of HDL production by the liver. Research has shown that the linoleic acid content of soy PI is critical to a peroxisome proliferator-activated receptor alpha dependent stimulation of HDL secretion. Soy-derived phospholipids uniquely affect cellular signaling and transcriptional processes. These lipids are safe and efficacious in humans and may therefore offer a novel therapeutic opportunity to treat cardiovascular disease.

Current opinion in investigational drugs

Phospholipids as cardiovascular therapeutics.

Author: Daniel L Sparks ; Nihar R Pandey

A uniquely formulated soy phospholipid is being developed as a potential therapeutic for the treatment and prevention of heart disease. Three phase I and one phase I/II clinical trials have been completed with soy phosphatidylinositol (PI). The compound was shown to be safe in all trials and at doses over 5 g. Clinical studies have also shown early-stage efficacy to suggest that PI is able to raise plasma HDL-cholesterol and apolipoprotein A-I levels, and reduce triglyceride levels in humans. PI directly impacts plasma HDL levels through a MAPK stimulation of HDL production by the liver. Research has shown that the linoleic acid content of soy PI is critical to a peroxisome proliferator-activated receptor alpha dependent stimulation of HDL secretion. Soy-derived phospholipids uniquely affect cellular signaling and transcriptional processes. These lipids are safe and efficacious in humans and may therefore offer a novel therapeutic opportunity to treat cardiovascular disease.

Biochemistry of Atherosclerosis

Reverse Cholesterol Transport

Author: Jonathon Boucher ; Christophe M. Chretien ; Jim W. Burgess ; Philip A. Sinclair ; Daniel L. Sparks

Atherosclerosis, the accumulation of cholesterol in the arteries resulting in heart attacks and strokes, is the leading cause of death in the USA and most other industrialized countries in the world. Plasma levels of high-density lipoprotein (HDL) cholesterol are invariably found to be inversely associated with the risk of atherosclerosis. This protective effect has classically been ascribed to HDL-mediated reverse cholesterol transport (RCT). In this process, nascent HDL in the circulation removes unesterified (free) cholesterol from peripheral cells, such as macrophages, through the transfer of cholesterol across the cell membrane by the ATP-binding cassette (ABCA1) transporter protein. The mature, spherical HDL particle, which contains these cholesterol esters in its core, then transfers the cholesterol to the liver through receptor-mediated processes. HDL cholesterol that is taken up by the liver is then excreted in the form of bile acids and cholesterol, completing the process of RCT. Because HDL-mediated RCT reduces serum cholesterol levels and is associated with a reduction in the risk of cardiovascular disease, increasing HDL is now being realized as a promising therapeutic end point.

100 Deals associated with Liponex, Inc.

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100 Translational Medicine associated with Liponex, Inc.

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Pipeline

Pipeline Snapshot as of 21 Jul 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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