Zhejiang Cheng Yi Pharmaceutical Co., Ltd.

The main purpose of the study is to investigate the relative bioavailability of the test preparation torsemide tablets (specification: 10 mg) and the reference preparation torsemide tablets (trade name: Unat®, specification: 10 mg) in healthy Chinese subjects after a single oral dose on an empty stomach or after a meal, analyze the pharmacokinetic parameters of the two preparations, and evaluate the bioequivalence of the two preparations. The secondary purpose of the study is to investigate the safety of the test preparation and the reference preparation in healthy Chinese adult subjects after a single oral dose on an empty stomach or after a meal.

(1) Primary study objective: To evaluate the bioequivalence of the test and reference preparations under fasting and postprandial conditions, using the calcitriol soft capsules (0.25 μg/capsule) provided by Zhejiang Chengyi Pharmaceutical Co., Ltd. as the test preparation and the calcitriol soft capsules (0.25 μg/capsule, trade name: Luogaiquan®) produced by Catalent Germany Eberbach GmbH as the reference preparation. (2) Secondary study objective: To observe the safety of the test and reference preparations in healthy subjects under fasting and postprandial conditions.

Primary objective: Using the thiopurine tablets (50 mg) produced by Zhejiang Chengyi Pharmaceutical Co., Ltd. as the test preparation and the thiopurine tablets (50 mg) produced by Quinn Pharmaceuticals, LLC as the reference preparation, the pharmacokinetic behavior of the two preparations in healthy Chinese subjects was compared according to the relevant provisions of the bioequivalence test, and the bioequivalence of the two preparations was evaluated. Secondary objective: To evaluate the safety of the test preparation and the reference preparation when the subjects took them orally on an empty stomach.