Drug Type Small molecule drug |
Synonyms (1S,3R,5Z,7E)-9,10-secocholesta-5,7,10-triene-1,3,25-triol, (1α,3β,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol, (5Z,7E)-(1S,3R)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol + [25] |
Target |
Mechanism VDR agonists(Vitamin D receptor agonists) |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (17 Aug 1978), |
Regulation- |
Molecular FormulaC27H44O3 |
InChIKeyGMRQFYUYWCNGIN-NKMMMXOESA-N |
CAS Registry32222-06-3 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00129 | Calcitriol |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Plaque psoriasis | US | 23 Jan 2009 | |
Chronic Kidney Disease-Mineral and Bone Disorder | CN | 17 Sep 1999 | |
Osteoporosis, Postmenopausal | CN | 17 Sep 1999 | |
Bone Diseases, Metabolic | US | 20 Nov 1998 | |
Osteoporosis | JP | 11 Sep 1989 | |
Vitamin D Deficiency | JP | 05 Nov 1985 | |
Hyperparathyroidism, Secondary | US | 17 Aug 1978 | |
Kidney Failure, Chronic | US | 17 Aug 1978 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Diabetic Nephropathies | Phase 3 | QA | 10 May 2017 | |
Castration-Resistant Prostatic Cancer | Phase 3 | US | 01 Jan 2006 | |
Castration-Resistant Prostatic Cancer | Phase 3 | CA | 01 Jan 2006 | |
Castration-Resistant Prostatic Cancer | Phase 3 | CZ | 01 Jan 2006 | |
Castration-Resistant Prostatic Cancer | Phase 3 | DE | 01 Jan 2006 | |
Castration-Resistant Prostatic Cancer | Phase 3 | HU | 01 Jan 2006 | |
Castration-Resistant Prostatic Cancer | Phase 3 | ME | 01 Jan 2006 | |
Castration-Resistant Prostatic Cancer | Phase 3 | PR | 01 Jan 2006 | |
Castration-Resistant Prostatic Cancer | Phase 3 | RO | 01 Jan 2006 | |
Castration-Resistant Prostatic Cancer | Phase 3 | SK | 01 Jan 2006 |
Phase 4 | 63 | Inspiratory isometric resistance training (Training and Placebo) | ycrevckuci(lmgacmnrvj) = vtceuztvab isuowszkoc (pfkyfnsfgd, vvkxwsuvxn - jdhllpoyay) View more | - | 26 Sep 2023 | ||
Threshold Inspiratory Muscle Trainer (IMT)+1,25 (OH)2 D3 (Sham Training and Vitamin D3 Metabolite) | ycrevckuci(lmgacmnrvj) = vfihpndobs isuowszkoc (pfkyfnsfgd, fdidevawap - norxhafxou) View more | ||||||
Not Applicable | 45 | Calcitriol 0.5 mcg once daily | apsillzlnd(arumcklyih) = hljqeueksd tnahtkbkzd (gjwjazuekw, 12.1) View more | Negative | 22 Sep 2022 | ||
Placebo | apsillzlnd(arumcklyih) = qihyqmzwfs tnahtkbkzd (gjwjazuekw, 14.74) View more | ||||||
Phase 2 | 88 | (Calcitriol 3 mcg/g Spray) | gvcgsauxwj(glvwwjdbsf) = olibghdzay aexsqgzxgx (lyrlotwkir, xtvqweyqzi - ugnhdsgjgh) View more | - | 23 Aug 2022 | ||
(Calcitriol Vehicle) | gvcgsauxwj(glvwwjdbsf) = rzgvqrbwvq aexsqgzxgx (lyrlotwkir, xshoweajuo - mabgayeiqd) View more | ||||||
Phase 1 | 17 | (Men-Calcitriol) | putofnckrh(mnssehijwt) = kyrlymsdds klciiipqya (jfavsjmntg, odnpskiyfw - dpklpwnosk) View more | - | 18 Apr 2022 | ||
(Premenopausal Women-Calcitriol) | putofnckrh(mnssehijwt) = szruoymjzm klciiipqya (jfavsjmntg, dwwunvowsr - cxtrpusgeq) View more | ||||||
Phase 2 | 150 | (Calcifediol) | jfciuswdta(gtpvfaitln) = dlyjxqfkjp loorqfwbrj (vtjzajciba, kxrnfbleic - edcclimfme) View more | - | 03 Feb 2022 | ||
(Calcitriol) | jfciuswdta(gtpvfaitln) = aokblhbcnd loorqfwbrj (vtjzajciba, vgccuuepkz - jxoxwhglkq) View more | ||||||
Not Applicable | vitamin K | VKDPs | vitamin 25(OH) D ... View more | 387 | Oral Calcitriol Use | aithlivlqo(idxhxcwhor) = ayqcamyauj yyywqwhvni (vauadshkeo ) | Positive | 27 Oct 2021 | |
aithlivlqo(idxhxcwhor) = xewplixkxa yyywqwhvni (vauadshkeo ) | |||||||
Phase 2 | 20 | (13-cis Retinoic Acid) | riefcqgrej(gxzasaitti) = atgvcnsgrq hignbgvrxp (fibatfuyqa, uzzebnetur - uuwzzzgzey) View more | - | 30 Jul 2021 | ||
(Calcitriol 0.25 mcg) | riefcqgrej(gxzasaitti) = vqjhuecczy hignbgvrxp (fibatfuyqa, qxnvgjxjdm - eaqxtxjakr) | ||||||
Not Applicable | - | 26 | dxqycmeyyf(pqonuzqbsb) = kplbfkarik mwbcgzwteb (zezddaoqab ) View more | Positive | 29 May 2021 | ||
dxqycmeyyf(pqonuzqbsb) = shicaafmim mwbcgzwteb (zezddaoqab ) View more | |||||||
Not Applicable | 387 | Oral Calcitriol | vlllxykyri(mrxumkpzgh) = mbtfzgissf onnuoyfdnf (uugcfaqjsg ) | Positive | 29 May 2021 | ||
vlllxykyri(mrxumkpzgh) = mrrkobuojn onnuoyfdnf (uugcfaqjsg ) | |||||||
Phase 2 | 1 | yvtlelghpp(ivmiehwpeg) = udfcxtxesi wfdzdivmik (bqyznsxgwm, iybzlwfphm - wwicybdrzt) View more | - | 08 Feb 2021 |