Hangzhou New Novartis Pharmaceutical Co., Ltd.

The macitentan tablets (specification: 10 mg) produced by Ningbo Minova Tiankang Pharmaceutical Co., Ltd. were used as the test preparation, and the macitentan tablets (trade name: Apoquel®, specification: 10 mg) licensed by Actelion Pharmaceuticals Ltd. were used as the reference preparation. The pharmacokinetic parameters of the two preparations were investigated in the fasting and postprandial state after a single dose, and whether the two preparations were bioequivalent was evaluated.

To investigate the relative bioavailability of the test preparation irbesartan hydrochlorothiazide tablets (specification: 150mg/12.5mg: each tablet contains 150mg irbesartan and 12.5mg hydrochlorothiazide, produced by Ningbo Menohua Tiankang Pharmaceutical Co., Ltd.) and the reference preparation irbesartan hydrochlorothiazide tablets (trade name: Ambron®; COAPROVEL®, specification: 150mg/12.5mg: each tablet contains 150mg irbesartan and 12.5mg hydrochlorothiazide, produced by Sanofi Winthrop Industrie) in healthy Chinese subjects after single oral administration on an empty stomach and after a meal, analyze the pharmacokinetic parameters of the two preparations, and evaluate the bioequivalence of the two preparations. Secondary study objectives: To evaluate the safety of the test preparation and the reference preparation in healthy Chinese adult subjects after single oral administration on an empty stomach and after a meal.

：Febuxostat tablets (specification: 40 mg) produced by Ningbo Minova Tiankang Pharmaceutical Co., Ltd. were used as the test preparation, and febuxostat tablets (specification: 40 mg, trade name: FEBURIC®/FEBURIC®) produced by TEIJIN PHARMA LIMITED IWAKUNI PHARMACEUTTCAL FACTORY were used as the reference preparation. The pharmacokinetic parameters of the test preparation and the reference preparation in healthy subjects were investigated in the fasting and postprandial states, and the bioequivalence of the two preparations was evaluated. Secondary study objectives: To observe the safety of the test preparation and the reference preparation in healthy subjects.