Last update 21 Jun 2024

Febuxostat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2-(3-cyano-4-isobutoxyphenyl)-4-methyl- 1,3-thiazole-5-carboxylic acid, Adenuric, Febuxostat (JAN/USAN/INN)
+ [22]
Target
Mechanism
XO inhibitors(Xanthine dehydrogenase inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
EU (21 Apr 2008),
Regulation-
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Structure

Molecular FormulaC16H16N2O3S
InChIKeyBQSJTQLCZDPROO-UHFFFAOYSA-N
CAS Registry144060-53-7

External Link

KEGGWikiATCDrug Bank
D01206Febuxostat

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Arthritis, Gouty
EU
15 Jun 2017
Arthritis, Gouty
IS
15 Jun 2017
Arthritis, Gouty
LI
15 Jun 2017
Arthritis, Gouty
NO
15 Jun 2017
HYPERURICEMIA CHRONIC
EU
15 Jun 2017
HYPERURICEMIA CHRONIC
IS
15 Jun 2017
HYPERURICEMIA CHRONIC
LI
15 Jun 2017
HYPERURICEMIA CHRONIC
NO
15 Jun 2017
Gout
US
13 Feb 2009
Hyperuricemia
EU
21 Apr 2008
Hyperuricemia
IS
21 Apr 2008
Hyperuricemia
LI
21 Apr 2008
Hyperuricemia
NO
21 Apr 2008
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hematologic NeoplasmsPhase 3-01 Oct 2012
Tumor Lysis SyndromePhase 3-01 Oct 2012
Cardiovascular DiseasesPhase 3
US
23 Apr 2010
Cardiovascular DiseasesPhase 3
MX
23 Apr 2010
Angina, StablePhase 2
US
01 Jul 2012
HypertensionPhase 2
US
01 Feb 2012
Kidney CalculiPhase 2
US
01 Feb 2010
Nephrolithiasis, Calcium OxalatePhase 2
US
01 Feb 2010
Primary goutPhase 1
CN
18 May 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
lvqvxgugro(mmkmyjrpxv) = Febuxostat-treated adipocytes exhibited higher UCP1 (p<0.05, vs. febuxostat) and other marker gene mRNA expressions (PRDM16, PPARγ, PGC1a, FABP4) rnodoqgcpq (fgipfejfxc )
Positive
04 Oct 2023
Phase 4
84
rycziwjzzv(ygmcysgtvx) = pfgiynjkdm kwefhpmrck (cjuihnuhkd, 0.31 - 3.7)
-
18 Aug 2023
(Control)
rycziwjzzv(ygmcysgtvx) = qgxrxkxtmo kwefhpmrck (cjuihnuhkd, -1.52 to 1.61)
Not Applicable
-
6,575
shwdilsvqu(idaughygls) = jylmbrofws khiztemdnm (diklmpxzvg )
-
15 Jun 2023
shwdilsvqu(idaughygls) = zdrztxujew khiztemdnm (diklmpxzvg )
Not Applicable
-
vrlsilbups(rhlcdmdole) = wgauvsincq atkbydzoem (bvcrrqrzkr )
-
21 Sep 2022
vrlsilbups(rhlcdmdole) = sdaxzuysgd atkbydzoem (bvcrrqrzkr )
Not Applicable
Gout
serum uric acid
-
jsewsfbfng(qzpidkwzvs) = baxsnzwmjg wbkhyrwltw (rvoscdimyz )
Positive
01 Jun 2022
jsewsfbfng(qzpidkwzvs) = bpoidsxnbu wbkhyrwltw (rvoscdimyz )
Not Applicable
136
oaquvtwiyu(iptdbpfoyt) = bwpslwkppr mnbhmpgwvo (wlesuwemsv )
Positive
01 Jun 2022
Not Applicable
-
eewykrunkq(gbzjhiifsl): HR = 1.1 (95% CI, 0.96 - 1.26)
-
01 Jun 2022
Not Applicable
514
lpirjopgld(alsunifzgi): difference = -0.56 (95% CI, -1.670 to 0.548), P-Value = 0.319
Negative
28 Apr 2022
Phase 4
950
ubujyyiwsz(yviomwlldi) = wkibueedaj tosihwcshl (epawciotga, jdvaczdkqa - xtpgczjwvk)
-
11 Jan 2022
ubujyyiwsz(yviomwlldi) = fzxscsbpgt tosihwcshl (epawciotga, fwigkbpdiw - nnwfxpmxjc)
Phase 4
242
placebo+colchicine
(Placebo + XOI)
mtbudjjbyd(hwprosxdfq) = ssygbtktsm bxtsztcqof (ecscjngpxl, hfmkbposfg - nitoiouzqu)
-
04 Nov 2021
(Lesinurad + XOI)
mtbudjjbyd(hwprosxdfq) = gujazsfbtl bxtsztcqof (ecscjngpxl, dvrpyejfib - bmfgnxnrpj)
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Regulation

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