Delving into the Latest Updates on National Institute for Viral Disease Control and Prevention, China CDC with Synapse

Overview

Tags

Infectious Diseases

Immune System Diseases

Urogenital Diseases

Therapeutic vaccine

Fusion protein

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Infectious Diseases	2
Immune System Diseases	1

Top 5 Drug Type	Count

Therapeutic vaccine	1
Fusion protein	1

Top 5 Target	Count

HIV-1 gag	1
IFNγ x Interleukins x NELFCD	1

This study aims to observe the tolerance and safety of recombinant adenovirus AIDS gag vaccine (Ad5-HIVgag) in adult HIV-infected patients receiving HAART treatment, in order to provide a safe dosing regimen for subsequent clinical trials; secondly, to gain a preliminary understanding of the immunogenicity of the vaccine.

Start Date-

Sponsor / Collaborator

National Institute for Viral Disease Control and Prevention, China CDC

100 Clinical Results associated with National Institute for Viral Disease Control and Prevention, China CDC

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0 Patents (Medical) associated with National Institute for Viral Disease Control and Prevention, China CDC

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1

Literatures (Medical) associated with National Institute for Viral Disease Control and Prevention, China CDC

Scientific ReportsQ3 · CROSS-FIELD

Novel susceptibility loci for A(H7N9) infection identified by next generation sequencing and functional analysis

Q3 · CROSS-FIELD

ArticleOA

Author: Zhao, Baihui ; Zhou, Jianfang ; Wang, Dayan ; Chen, Jian ; Mao, Shenghua ; Teng, Zheng ; Sun, Ye ; Huang, Hailiang ; Zheng, Xiaodong ; Wu, Hao ; Zhou, Wei ; Shen, Lu ; Chen, Yongkun ; Shu, Yuelong ; Fang, Fanghao ; Cheng, Guangxia ; Zhao, Xue ; Sun, Liangdan ; Qin, Shengying ; Bai, Tian ; Chu, Wei ; He, Lin ; Zhang, Xi ; Huai, Cong ; Li, Mo

AbstractThe A(H7N9) virus strain that emerged in 2013 was associated with a high fatality rate and may become a long-term threat to public health. A(H7N9) disease incidence is disproportionate to viral exposure, suggesting that host genetic factors may significantly influence susceptibility to A(H7N9) infection. Human genome variation in conferring risk for A(H7N9) infection in Chinese populations was identified by a two-stage investigation involving 121 A(H7N9) patients and 187 healthy controls using next generation sequencing followed by functional analysis. As a result, a low frequency variant (rs189256251; P = 0.0303, OR = 3.45, 95% CI 1.05–11.35, chi-square test) and three HLA alleles (DQB1*06:01, DQA1*05:05 and C*12:02) were identified in A(H7N9) infected volunteers. In an A549 cell line carrying the rs189256251 variant CT genotype, A(H7N9) infection incidence was elevated 6.665-fold over control cells carrying the CC genotype. Serum levels of interferon alpha were significantly lower in patients with the CT genotype compared to the CC genotype (P = 0.01). The study findings of genetic predisposition to A(H7N9) in the Chinese population may be valuable in systematic investigations of A(H7N9) disease etiology.

100 Deals associated with National Institute for Viral Disease Control and Prevention, China CDC

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100 Translational Medicine associated with National Institute for Viral Disease Control and Prevention, China CDC

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Pipeline

Pipeline Snapshot as of 08 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

1

Phase 1 Clinical

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Ad5-HIVgag(National Institute for Viral Disease Control and Prevention, China CDC) ( HIV-1 gag )	-	Phase 1
CN117285652 ( IFNγ x Interleukins x NELFCD )	Virus Diseases More	Discovery