Last update 01 Nov 2024

Interleukins x IFNγ x NELFCD

Last update 01 Nov 2024

Basic Info

Related Targets

InterleukinsIFNγNELFCD

Drugs associated with Interleukins x IFNγ x NELFCD

CN117285652

Patent Mining

Target

IFNγ x Interleukins x NELFCD

Mechanism-

Active Org.

National Institute for Viral Disease Control and Prevention, China CDC

Originator Org.

National Institute for Viral Disease Control and Prevention, China CDC

Active Indication

Virus Diseases

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with Interleukins x IFNγ x NELFCD

100 Translational Medicine associated with Interleukins x IFNγ x NELFCD

0 Patents (Medical) associated with Interleukins x IFNγ x NELFCD

136

Literatures (Medical) associated with Interleukins x IFNγ x NELFCD

17 Sep 2024·Clinical and experimental rheumatology

Th1/Th2 associated transcription factors and cytokines in pregnancies with systemic lupus erythematosus.

Article

Author: Liu, Wenping ; Han, Xiao ; Yin, Gaohui ; Wang, Jibo ; Zhang, Shumin ; Jiang, Yanan

OBJECTIVESTh1/Th2 shift occurs during pregnancy. Systemic lupus erythematosus (SLE) flares may induce the dysregulation of Th1 and Th2 cells. We aimed to investigate the dynamic changes of Th1/Th2 associated transcription factors and cytokines in patients with SLE during pregnancy.METHODSTwenty-five pregnant patients with SLE and twenty-two healthy age-matched women served as controls from September 2021 to March 2022 were enrolled in the study. Real-time quantitative reverse transcription polymerase chain reaction analysis of peripheral blood mononuclear cells were performed to measure the expression of Th1 specific transcription factors T-bet, cytokine IFN-γ, and Th2 specific transcription factors GATA3, cytokine IL-4. The main statistical analysis methods were t test, Mann-Whitney U-test, Pearson correlation and Spearman rank correlation analysis.RESULTSThe mRNA level of IFN-γ and the relative expression of T-bet/GATA3 and IFN-γ/IL-4 in SLE patients were significantly higher than those in healthy individuals, whereas the GATA3 expression is lower in pregnant patients with SLE (p<0.001, p<0.05, p<0.05 and p<0.01 during the whole pregnancy, respectively; p<0.05, p<0.01, p<0.05 and p<0.05 specifically for the 3rd trimester, respectively). There were significant correlations between T-bet and IFN-γ (r=0.492, p<0.05), and between T-bet/GATA3 and IFN-γ/IL-4 (r=0.482, p<0.05).CONCLUSIONSOur work indicates that in SLE patients Th1/Th2 shift is blocked with up-regulation of Th1 cell function and insufficient Th2 polarisation during pregnancy, which may be involved in adverse pregnancy outcomes.

31 May 2024·The FASEB Journal

Mesenchymal stromal cells protect tissues from Th1 immune responses via IL‐11 secretion

Article

Author: Cho, WonKyung J ; Pulimamidi, Vinay K ; Mittal, Sharad K ; Chauhan, Sunil K

AbstractMesenchymal stromal cells (MSCs) have been shown to modulate the function of various subsets of T cells such as naïve CD4+ T cells and IFNγ+CD4+ Th1 cells; however, mechanisms underlying this regulation have not been fully deciphered. Our in vitro culture assays demonstrate that MSCs suppress the activation and function of CD4+ T cells by secreting interleukin 11, and neutralization of IL11 abrogates MSC‐mediated suppression of CD4+ T cell function. Moreover, delayed‐type, exogenous supplementation of IL11 significantly suppressed IFNγ+ expression by Th1 cells. Th1 and CD8+ cells play central roles in T cell‐mediated tissue damage. Using a murine model of hypersensitivity response to study T cell‐mediated tissue damage, we show that silencing IL11 in MSCs significantly abates the capacity of MSCs to suppress the generation of IFNγ‐secreting CD4+ and CD8+ cells, failing to prevent T cell‐mediated tissue inflammation and tissue damage.

01 Apr 2024·European Journal of Immunology

Characterization of human CD4⁺EOMES⁺GzmK⁺ T‐cell subsets unveils an uncoupling of suppressive functions from IL‐10‐producing capacities

Article

Author: Abrignani, Sergio ; Silvetri, Ylenia ; Pulvirenti, Nadia ; Sarnicola, Maria Lucia ; Crosti, Maria Cristina ; Prati, Daniele ; Carelli, Elena ; Valenti, Luca ; Moschetti, Giorgia ; Geginat, Jens ; Vasco, Chiara ; Gruarin, Paola ; Bosotti, Roberto ; Clemente, Francesca

Human CD4⁺EOMES⁺ T cells are heterogeneous and contain Th1-cells, Tr1-cells, and CD4⁺CTL. Tr1- cells and non-classical EOMES⁺ Th1-cells displayed, respectively, anti- and pro-inflammatory cytokine profiles, but both expressed granzyme-K, produced IFN-γ, and suppressed T-cell proliferation. Diffusion map suggested a progressive CD4⁺T-cell differentiation from naïve to cytotoxic cells and identified EOMES⁺Th1-cells as putative Tr1-cell precursors (pre-Tr1).

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