Jsc Grindeks

Primary objective: To evaluate the efficacy of meldonium plus standard therapy compared with standard therapy plus placebo in patients with chronic ischemic heart failure (NYHA class II-III) Secondary objective: To evaluate the safety of meldonium in patients with chronic ischemic heart failure

The purpose of this trial is to conduct a human pharmacokinetic study on meldonium injection, to study the pharmacokinetics of meldonium injection after single and multiple doses in healthy subjects, so as to understand the pharmacokinetic laws of meldonium injection in Chinese people and provide a basis for the dosing regimen of clinical research.

The purpose of this study is to conduct a human pharmacokinetic study on Meldonium Capsules, and to study the pharmacokinetics of Meldonium Capsules after single and multiple administrations in healthy subjects, so as to understand the pharmacokinetic laws of Meldonium Capsules in Chinese people and provide a basis for the dosing regimen in clinical studies.