Hainan Huluwa Pharmaceutical Group Co., Ltd.

Chinese healthy subjects were used as test subjects. A self-cross-controlled experimental design was adopted to determine the time course of cefpodoxime plasma concentration in healthy subjects after administration of the test formulation of cefpodoxime proxetil dry suspension, estimate the corresponding pharmacokinetic parameters, and use the cefpodoxime proxetil dry syrup [trade name: Banan®, specification: 50 mg/g, 100 g/bottle] certified by Daiichi Sankyo Co., Ltd. as a reference to evaluate the bioequivalence between the preparations and observe the safety of cefpodoxime proxetil dry suspension in Chinese healthy subjects.

Primary objective: Using ezetimibe and rosuvastatin calcium tablets (specifications: rosuvastatin calcium 10 mg/ezetimibe 10 mg) certified by Sanofi-Aventis, S.R.O. as the reference preparation and ezetimibe and rosuvastatin calcium tablets certified by Hainan Huluwa Pharmaceutical Group Co., Ltd. as the test preparation, a single-center, randomized, open, single-dose, two-preparation, two-sequence, four-period, completely repeated crossover clinical study was conducted to evaluate the bioequivalence of the two preparations under fasting and fed conditions. Secondary objective: To observe the safety of the test preparation and the reference preparation in healthy Chinese subjects.

Main purpose: To observe the single oral administration of the test preparation Sildenafil Citrate Orally Dissolvable Film (Specification: 20mg; Manufacturer: Hainan Huluwa Pharmaceutical Group Co., Ltd.) to Chinese healthy subjects in the fasting/postprandial state. and the pharmacokinetic characteristics of the reference preparation Sildenafil Citrate Orally Dissolved Film (trade name: Revatio®; specification: 20 mg; license holder and manufacturer: Revail Co., Ltd.), and fasting/meal evaluation Bioequivalence of the two formulations in healthy subjects at the latter state. Secondary purpose: To observe the safety of the test preparation sildenafil citrate orally dissolving film and the reference preparation sildenafil citrate orally dissolving film (Revatio®) in Chinese healthy subjects.