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Disease Domain	Count

Nervous System Diseases	1

Top 5 Drug Type	Count

Small molecule drug	1

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ADRA2(Adrenergic receptors alpha-2)	1

Author: Landini, Walter ; Bosio, Giulia ; Urbina, Mario ; Mazzoli, Stefano ; Varas-Malca, Rafael ; Pierantoni, Pietro Paolo ; Di Celma, Claudio ; Gastaldello, Maria Elena ; Pedini, Matteo ; Marramà, Giuseppe ; Lambert, Olivier ; Carnevale, Giorgio ; Bianucci, Giovanni ; Malinverno, Elisa ; Nobile, Francesco ; Collareta, Alberto ; Pellegrino, Luca

01 Jun 2025·Applied Surface Science

Interplay of deposition kinetics with metal diffusion in MoO3-Cu heterojunctions

Author: Minicucci, M. ; Torretti, E. ; Paparoni, F. ; Douillard, L. ; Faure, M. ; Marcelli, A. ; Lockwood, N. ; Spataro, B. ; Rollin, E. ; Cook, J. D. ; O'Neill, W. ; D'Elia, A. ; Di Cicco, A. ; Rezvani, S. J. ; Sparkes, M.

Metal oxide-metal heterojunctions are tunable structural and electronic systems characterised by defect d. and diffusion properties.The junction formation's kinetics and adatoms surface energy affect both nucleation and diffusion processes.The mechanism and the dependence of structural and electronic properties on these parameters are still not truly understood.Structural and electronic configuration dynamics of MoO₃ thin films deposited on metallic Cu and Si wafer are investigated by changing the kinetics of the deposition.Films obtained by Pulsed Laser Deposition and Thermal Evaporation techniques having different kinetic energy ranges are compared.It is shown that the diffusion competition between oxide and metallic elements on the amorphous layer plays a critical role in the formation of vacancies and the ionic redistribution within the junction.It is also shown that the metallic diffusion can be tuned via the interchange between the incident adatoms' initial kinetic energy and the diffusion time during the post-deposition thermal life cycle.These results help to understand the mechanism of the ionic redistribution and dynamics at the oxide/metal junction, providing a tool for tuning structural and electronic properties.

24 Mar 2025·Journal of Physics D: Applied Physics

Structure and phase dynamics in electrospray deposited amorphous MoO₃ via thermal treatment

Author: Passacantando, M. ; Azizinia, M. ; Minicucci, M. ; Gunnella, R. ; Rezvani, S. J.

AbstractMolybdenum oxides with distinct structures and phases have shown unique properties that are of interest in many scientific and technological applications. However, the scalability to large area deposition and in particular the deposition of surfaces with specific topology, with a uniform and controlled structure still remains a challenge. In this work, a uniform MoO3 film with amorphous structure was achieved via electrospray deposition from fine particle dispersion in water. A high vapor pressure solvent was utilized for the progress of the deposition. As-deposited films with large thicknesses (

<1 μ

m) show amorphous structures with a mean roughness lower than ∼32 nm. The deposited film was subsequently subject to thermal treatment with optimal thermodynamic parameters in order to modify the structure, the phase, the defect density and subsequently the electronic properties of the final structure. It is shown that a uniform coating layer with controlled structure and defect density can be achieved. This method facilitates the deposition of oxide layers on a variety of unconventional surfaces with large area as well as curved geometry.

100 Deals associated with University of Camerino

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100 Translational Medicine associated with University of Camerino

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Pipeline

Pipeline Snapshot as of 15 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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5

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Alpha 2 adrenoceptor agonists(University of Camerino) ( ADRA2 )	Pain More	Preclinical
Cyclazosin ( α1D-AR )	Hypertension More	Pending
Spipethiane ( σ1 receptor )	Analgesia More	Pending
Imidazofurin ( IMPDH )	Neoplasms More	Pending
M3 receptor antagonists( Università di Camerino) ( M3 receptor )	-	Pending