Yiqiao Hunan Pharmaceuticals Co. Ltd.

Main study objectives: To investigate the pharmacokinetic characteristics of the test preparation of tizanidine hydrochloride tablets (specification: 2 mg, produced by Jiangsu Hechen Pharmaceutical Co., Ltd.) and the reference preparation of tizanidine hydrochloride tablets (trade name: Sirdalu, specification: 2 mg, produced by Novartis Farma S.p.A.) in healthy adult subjects after a single oral administration under fasting conditions, and to evaluate the bioequivalence of the two preparations when taken orally under fasting conditions. Secondary study objectives: To evaluate the safety of the test preparation of tizanidine hydrochloride tablets and the reference preparation (trade name Sirdalu) in healthy adult subjects after a single oral administration under fasting conditions.

Main study objectives: To investigate the pharmacokinetic characteristics of the test preparation of tizanidine hydrochloride tablets (specification: 2 mg, produced by Jiangsu Hechen Pharmaceutical Co., Ltd.) and the reference preparation of tizanidine hydrochloride tablets (trade name: Sirdalud, specification: 2 mg, produced by Novartis Farma S.p.A.) in healthy adult subjects after a single oral administration in the fed state, and to evaluate the bioequivalence of the two preparations after oral administration in the fed state. Secondary study objectives: To evaluate the safety of the test preparation of tizanidine hydrochloride tablets and the reference preparation (trade name: Sirdalud) in healthy adult subjects after a single oral administration in the fed state.

To investigate the pharmacokinetic characteristics of a single oral dose of 1 tablet of Dedostat Tablets [Study Preparation A, Specification: 25 mg] provided by Kangzhe (Hunan) Pharmaceutical Co., Ltd. and a single oral dose of 1 tablet of Dedostat Tablets [Study Preparation B, Specification: 25 mg] provided by Kangzhe (Hunan) Pharmaceutical Co., Ltd. in healthy subjects under fasting conditions, and to investigate the bioequivalence and safety of the two preparations