Shenyang Shuangding Pharmaceutical Co., Ltd.

1. To evaluate the effectiveness of ibuprofen injection in the adjuvant treatment of moderate to severe pain after laparoscopic (single incision ≥ 5 cm), abdominal or orthopedic surgery, using the total amount of morphine used within 24 hours after surgery as the primary efficacy indicator and placebo as the control; 2. To evaluate the safety of ibuprofen injection through laboratory tests, clinical symptoms, signs, adverse events/serious adverse events, etc.

Using placebo as a control, evaluate the efficacy and safety of pidotimod injection in the adjuvant treatment of AECOPD caused by bacterial infection, and explore the optimal effective dose.

Starting from a safe initial dose, the safety and tolerability of a single intravenous infusion of pidotimod injection in healthy Chinese volunteers was investigated.