Delving into the Latest Updates on Xinxiang Medical University with Synapse

Overview

Tags

Digestive System Disorders

Neoplasms

Nervous System Diseases

Small molecule drug

Chemical drugs

Natural Killer Cell Therapies

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	3
Infectious Diseases	1
Immune System Diseases	1
Nervous System Diseases	1

Top 5 Drug Type	Count

Small molecule drug	2
Chemical drugs	2
CAR-NK	1
Fusion protein	1
Natural Killer Cell Therapies	1

Top 5 Target	Count

METTL3(methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit)	2
Chemokine ligands x HBZ	1
NQO1(Quinone reductase 1)	1
NKG2D(NKG2-D type II integral membrane protein)	1
ID2(inhibitor of DNA binding 2)	1

Alzheimer's disease (AD), characterized by its incurable nature and prevalence among the elderly, has remained a focal point in medical research. Increasing evidence suggests that peroxynitrite (ONOO^-) serves as a crucial biomarker for the diagnosis of AD. In this study, we present a novel, easily available, high-yield, and cost-effective near-infrared (NIR) fluorescent probe, CDCI-ONOO. This probe utilizes a coumarin-dicyanoisophorone conjugate as the fluorophore and diphenylphosphinic chloride as the recognition site, enabling the detection of ONOO^- both in vitro and in vivo. Upon interaction with ONOO^-, CDCI-ONOO exhibits a distinct maximum emission peak at 715 nm with a substantial Stokes shift of 184 nm. The probe demonstrates excellent selectivity and sensitivity (LOD = 144 nM), along with noticeable colorimetric and fluorescence changes after the reaction. Comprehensive analyses using high-performance liquid chromatography (HPLC), high-resolution mass spectrometry (HRMS), and density functional theory (DFT) calculations confirm that the reaction with ONOO^- restores the initially quenched Intramolecular Charge Transfer (ICT), resulting in the formation of CDCI-OH, a product that emitting fluorescence in the near-infrared region. Furthermore, we demonstrated the successful application of CDCI-ONOO for ONOO^- detection in neuronal cells and imaging of ONOO^- in the brains of mice. These findings underscore the potential of CDCI-ONOO as a near-infrared fluorescent probe for in vivo ONOO^- detection, offering a significant avenue for advancing our understanding of AD pathology and diagnosis.

01 Jan 2025·Gene

Construction and evaluation of a Salmonella Paratyphi A vaccine candidate based on a poxA gene mutation

Article

Author: You, Yonghe ; He, Qunli ; Jie, Jiayue ; Zhou, Yanlin ; Hao, Zhenhua ; Xie, Yongsheng ; Zhao, Xiaohui

Salmonella Paratyphi A, the pathogen of paratyphoid A accounts for an obviously growing proportion of cases in many areas. Therefore, development of specific paratyphoid A vaccines is needed. In the present study, the poxA gene of Salmonella Paratyphi A, encoding the aminoacyl-tRNA synthetase, was deleted successfully by the method of lambda Red recombination system, the resulting strain, ΔpoxA was characterized in respect of growth, adhesion and invasion, virulence, immunogenicity and protective efficacy. It was found that the growth of the ΔpoxA strain was significantly delayed compared with the wild type strain, the mutant ΔpoxA was less invasive to Caco-2 BBE epithelioid cells and THP-1 macrophages than the wild type strain, strain ΔpoxA was attenuated at least 1000-fold in mice, significant immune response and efficient protection were provided by the mutant ΔpoxA after oral immunization. It is concluded that the Salmonella Paratyphi A poxA deletion mutant ΔpoxA can be used as a live oral vaccine candidate against paratyphoid A.

01 Jan 2025·Journal of Colloid and Interface Science

Facile fabrication of a thermal/pH responsive IPN hydrogel drug carrier based on cellulose and chitosan through simultaneous dual-click strategy

Article

Author: Li, Songmao ; Yu, Hui ; Wu, Yuxuan ; Hu, Chunwang ; Guo, Tao ; Wang, Gang ; Zhang, Bing ; Chen, Hongli ; Wei, Hongliang ; Wang, Mengyuan

Herein, an interpenetrating network hydrogel (IPN-Gel) based on cellulose and chitosan was synthesized via simultaneous amino-anhydride and azide-alkyne click reaction in water in one pot. The samples were characterized by various analytical methods including FTIR, SEM, XRD, XPS, ¹H NMR and so forth. The fabrication conditions were optimized by single factor experiments with water uptake (WU) and gel mass fraction (GMF) as two indexes. The WU and GMF of the IPN-Gel prepared under optimized conditions were 1192.37 % and 74.00 %, respectively. Its WU descended with the ascension in temperature, and first descended and then gradually ascended with the ascension in pH, confirming that the IPN-Gel had thermal/pH dual responsiveness. Using 5-Fu as a model drug, the release behavior of 5-Fu in IPN-Gel was explored. Its release behavior could be regulated by changing temperature and pH values, and it followed the Korsmeyer Peppas model. The viability of 4 T1 cells and HUVEC cells exceeded 80 % after 48 h of incubation at a high concentration of 200 μg/mL IPN-Gel, and hemolytic percentage was below the allowed limit of 5 %. The study provides a new strategy for the preparation of the IPN-Gel with biocompatibility, swelling reversibility and controllable drug release.

100 Deals associated with Xinxiang Medical University

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100 Translational Medicine associated with Xinxiang Medical University

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Pipeline

Pipeline Snapshot as of 28 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

1

4

Preclinical

Phase 1 Clinical

2

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

NKG2D-CAR-NK92 cells(Xinxiang Medical University) ( NKG2D )	Solid tumor More	Phase 1
NK Cells(Xinxiang Medical University)	COVID-19 More	Phase 1
F039-0002 ( METTL3 )	Colitis More	Preclinical
AK-778-XXMU ( ID2 )	Glioma More	Preclinical
7460-0250 ( METTL3 )	Colitis More	Preclinical