[Translation] A randomized, double-blind, placebo-controlled, single- and multiple-dose ascending Phase I clinical study to evaluate the safety, tolerability and pharmacodynamics of WS012 in healthy adult subjects in China
主要目的:
评估WS012在中国健康成人受试者中单次和多次口服给药的安全性和耐受性。
次要目的:
评估WS012在中国健康成人受试者中单次和多次口服给药的总胆汁酸(TBA)和粪便中TBA的药效动力学。
探索性目的:
探索健康受试者多次口服给药WS012对血脂(TG、TC、HDL-C、LDL-C)的影响。
[Translation] main purpose:
To assess the safety and tolerability of single and multiple oral administrations of WS012 in healthy Chinese adult subjects.
Secondary purpose:
To evaluate the pharmacodynamics of WS012 in total bile acids (TBA) and fecal TBA following single and multiple oral administrations in healthy adult subjects in China.
Exploratory purpose:
Explore the effects of multiple oral administrations of WS012 on blood lipids (TG, TC, HDL-C, LDL-C) in healthy subjects.