FOXP3

London, UK – October 22, 2024 – Quell Therapeutics Ltd (“Quell”), a leader in developing engineered T-regulatory (Treg) cell therapies for serious medical conditions driven by the immune system, announces upcoming oral and poster presentations at the 2024 European Society of Gene and Cell Therapy (ESGCT) 31st Annual Congress, held in Rome, Italy (October 22-25, 2024) and at the American Association for the Study of Liver Diseases (AASLD) The Liver Meeting, held in San Diego, CA (November 15-19). An oral presentation at ESGCT and a poster presentation at The Liver Meeting will highlight progress of the LIBERATE study of its lead CAR-Treg candidate QEL-001 to safely induce donor-specific tolerance in liver transplant patients thereby overcoming limitations encountered with previous clinical approaches. The clinical data being presented from the safety cohort demonstrate that QEL-001 is well-tolerated, has shown cell persistence post infusion up to six months and has a stable phenotype over time via FOXP3 and HELIOS expression. In addition, analysis of liver biopsies has confirmed the trafficking, engraftment, and phenotypic stability of the QEL-001 product in the transplanted livers. Having successfully completed the safety cohort, Quell is advancing QEL-001 in the efficacy cohort of the Phase 1/2 LIBERATE clinical trial in liver transplant patients. A poster presentation at ESGCT will describe progress in developing a differentiation process to generate Treg cells from iPSC stem cells, which will enable the future development of allogenic cell therapies for autoimmune and inflammatory diseases. The in vitro characterization data demonstrates the identity, stability and functionality of the iPSC-derived Tregs, which exhibit potent suppressive activity. Quell is advancing further development of the iPSC-Treg platform in collaboration with Cellistic, a specialist in process development and manufacture of immune cell therapies based on human iPSC technology. Details of the presentations can be found below: At ESGCT (October 22-25 – abstracts available to registered attendees by clicking here) Oral presentation: Abstract Title: CAR-Treg cell therapy to induce tolerance in liver transplantation – LIBERATE clinical trialAbstract Number: OR084Date & Time: Thursday, October 24, 2024; 3:30 p.m. - 5:30 p.m. (CET)Session: 9c – Immunotherapy and CAR-T Cells IIRoom: Meeting Room 2Presenter: Rupert Kenefek, PhD, Senior Director Translational Sciences at Quell Therapeutics Poster presentation: Abstract Title: Development and characterization of iPSC-derived regulatory T cells – Towards an allogenic cell therapy for the treatment of autoimmunity and inflammatory conditionsAbstract Number: PO368Date & Time: Wednesday, October 23, 2024; 1:30 p.m. - 3:00 p.m. (CET)Session: Poster Session IIPresenter: Sophie Howson, Scientist at Quell Therapeutics At The Liver Meeting (November 15-19 – abstract available by clicking here) Poster Presentation Abstract Title: The Safety and Tolerability of QEL-001, an Autologous Chimeric Antigen Receptor (CAR) T Regulatory (Treg) Cell Therapy, in Liver Transplantation – A Safety Cohort in the LIBERATE StudyAbstract Number: 1386Date & Time: Saturday, November 16, 2024; 1:00 p.m. - 2:00 p.m. (PST)Session: Poster Session IIPresenter: Alberto Sanchez-Fueyo, Professor of Hepatology and Academic Head of the Institute of Liver Studies at King’s College London, and Honorary Transplant Hepatology Consultant at King’s College Hospital, and Co-Founder of Quell Therapeutics ### About Quell TherapeuticsQuell Therapeutics is the world leader in developing engineered T-regulatory (Treg) cell therapies that aims to harness, direct and optimize their immune suppressive properties to address serious medical conditions driven by the immune system. The Company is leveraging its pioneering Foxp3 Phenotype Lock™ technology, unique multi-modular platform and integrated manufacturing capabilities to design and develop a pipeline of highly engineered Treg cell therapies with greater potential for persistence, potency and stability than earlier generations of Treg cell therapy approaches. Quell’s lead candidate QEL-001 is advancing in the Phase 1/2 LIBERATE clinical trial designed to investigate its ability to induce operational tolerance following liver transplantation, with the potential to protect the post-transplant liver without the need for chronic immunosuppressive medications. Quell is also advancing additional programs in neuroinflammatory and autoimmune diseases internally and in partnership with AstraZeneca. www.quell-tx.com. Contacts Media: Mark Swallow, PhD, Sandi Greenwood MEDiSTRAVA Quell-Tx@Medistrava.comInvestors: Corey Davis, PhD LifeSci Advisors cdavis@lifesciadvisors.com

Multi-year agreement focuses on the manufacture of multiple CAR-Treg product candidates for Phase 1/2 clinical studies Partnership builds on long-term relationship to provide Quell with additional dedicated GMP capacity, infrastructure and resources at eXmoor’s new, state-of-the-art Cell & Gene Therapy Centre London, UK and Bristol, UK, 24 September 2024 – Quell Therapeutics Ltd (“Quell” or “the Company”), a world leader in developing engineered T-regulatory (Treg) cell therapies for serious medical conditions driven by the immune system, and eXmoor pharma (“eXmoor”), the full-service cell and gene therapy (CGT) manufacturing partner, announce a strategic partnership for the manufacture of multiple autologous engineered CAR-Treg cell therapies in Quell’s pipeline targeting autoimmune diseases. Quell leverages its pioneering Foxp3 Phenotype Lock™ technology and unique multi-modular platform to design and develop highly engineered Treg cell therapies that are effectively targeted, exhibit potent immune regulatory function and are persistent and stable in the target tissue. Quell has developed considerable expertise in process development and manufacture of CAR-Treg product candidates, which is being used to deliver scaled and consistently high-quality product for use in its ongoing LIBERATE Phase 1/2 trial with QEL-001 in liver transplant patients. Under the terms of this multi-year agreement, Quell and eXmoor will partner on the process transfer, scale-out and Phase 1/2 clinical manufacture of multiple autologous CAR-Treg cell therapy candidates in Quell’s pipeline. eXmoor will dedicate manufacturing capacity within its new state-of-the-art Cell & Gene Therapy Centre in Bristol, UK. In August 2024, eXmoor announced it had received its GMP license from the MHRA, completing its journey to becoming a full-service contract development and manufacturing organization (CDMO) with integrated process development and analytical labs, four GMP clean rooms and fill/finish capability to support scale-up, optimization and manufacture of cell therapies, RNA therapies and viral vectors. Aaron Vernon, Chief Manufacturing Officer at Quell Therapeutics, said: “Building on our manufacturing experience producing QEL-001 for the LIBERATE clinical trial, this partnership will provide increased capacity to manufacture our emerging pipeline of CAR-Treg product candidates and move them into clinical development. Quell and eXmoor have worked productively and successfully together for several years, and we are excited to extend our relationship with them to support our clinical manufacturing needs.” “Quell’s CAR-Treg expertise and our long-standing collaboration make them an excellent first manufacturing client in our new, state-of-the-art facilities and we are committed to creating a true partnership,” said Angela Osborne, CEO of eXmoor pharma. “eXmoor’s first cell therapy experience in 2007 was with Tregs so there is symmetry in this being the focus of our first manufactured products. Quell has made tremendous progress with its therapeutic programs and we are proud to be supporting them in accelerating the progression of their next-generation cell therapies into patient trials.” Pictured: Iain McGill, CEO of Quell Therapeutics, and Angela Osborne, CEO of eXmoor pharma ### About Quell TherapeuticsQuell Therapeutics is the world leader in developing engineered T-regulatory (Treg) cell therapies that aims to harness, direct and optimize their immune suppressive properties to address serious medical conditions driven by the immune system. The Company is leveraging its pioneering Foxp3 Phenotype Lock™ technology, unique multi-modular platform and integrated manufacturing capabilities to design and develop a pipeline of highly engineered Treg cell therapies with greater potential for persistence, potency and stability than earlier generations of Treg cell therapy approaches. Quell’s lead candidate QEL-001 is advancing in the LIBERATE clinical trial designed to investigate its ability to induce operational tolerance following liver transplantation, with the potential to protect the post-transplant liver without the need for chronic immunosuppressive medications. Quell is also advancing additional programs in neuroinflammatory and autoimmune diseases internally and in partnership with AstraZeneca. www.quell-tx.com. About eXmoor pharmaeXmoor pharma is a one-stop cell-and-gene-therapy partner accelerating the manufacturing journey from research to patients. Founded in 2004, eXmoor has specialized in the CGT sector since 2007, helping organisations to understand, plan and implement the appropriate CMC strategy. eXmoor does this via its combination of GMP manufacturing capability and its translation and capital consulting groups, including process and analytical development labs. eXmoor has completed over 500 projects for 150 organizations and is headquartered in Bristol, UK, with 80 current employees, growing to 200 by 2027. exmoorpharma.com. Contacts For Quell TherapeuticsLuke Henry, Chief Business OfficerIR@quell-tx.com Media: Mark Swallow, Frazer Hall, Sandi GreenwoodMEDiSTRAVA Quell-Tx@Medistrava.com Investors: Corey Davis, PhDLifeSci Advisorscdavis@lifesciadvisors.com For eXmoor PharmaLaura Murray, Business Development ManagerBD@eXmoorpharma.com Media: IB CommunicationsTel +44 (0)20 89434685exmoor@ibcomms.agency

BOSTON, Sept. 03, 2024 (GLOBE NEWSWIRE) -- Cue Biopharma, Inc. (Nasdaq: CUE), a clinical-stage biopharmaceutical company developing a novel class of therapeutic biologics to selectively engage and modulate disease-specific T cells, today announced that members of its management team will deliver two presentations at The Promise of Interleukin-2 Therapy Conference, taking place September 4-7, 2024 in Paris, France. Presentation DetailsDate and Time: Friday, September 6, 2024, 4 p.m. CET Presentation Title: CUE-401: A Novel IL-2/TGF-beta fusion protein for the induction & expansion of FOXP3+ regulatory T CellsPresenter: Steven Quayle, Ph.D., vice president & head, Biology Research & Translational Medicine, Cue Biopharma Dr. Quayle will present preclinical data on our first-in-class bispecific fusion protein, CUE-401, which induces and expands regulatory T cells (Tregs) through the co-delivery of interleukin 2 (IL-2) and transforming growth factor beta (TGF-β), and how this approach differentiates from other Treg-directed therapies. Date and Time: Saturday, September 7, 2024, 9 a.m. CET Presentation title: Clinical safety and efficacy of TCR-specific engagers that selectively target IL-2 to tumor-specific T cells Presenter: Matteo Levisetti, M.D., chief medical officer, Cue Biopharma Dr. Levisetti will discuss how the company’s lead oncology programs CUE-101 and CUE-102, representative of the CUE-100 series of Immuno-STAT™ biologics, enable selective targeting of the cytokine IL-2 to tumor specific T cells for enhanced efficacy and safety profiles. About Cue BiopharmaCue Biopharma, a clinical-stage biopharmaceutical company, is developing a novel class of injectable biologics to selectively engage and modulate disease-specific T cells directly within the patient’s body. The company’s proprietary platform, Immuno-STAT™ (Selective Targeting and Alteration of T cells), and biologics are designed to harness the curative potential of the body’s intrinsic immune system through the selective modulation of disease-specific T cells without the adverse effects of broad systemic immune modulation. Headquartered in Boston, Massachusetts, we are led by an experienced management team and independent Board of Directors with deep expertise in immunology and immuno-oncology as well as the design and clinical development of protein biologics. For more information please visit www.cuebiopharma.com and follow us on X and LinkedIn. Forward-Looking StatementsThis press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements include, but are not limited to, those regarding: the company’s belief regarding the potential benefits and applications of its drug candidates and programs, including the transformational potential of the company’s Immuno-STAT™ platform to accomplish its mission of developing breakthrough immunotherapies to establish a new standard of care in the treatment of cancer and autoimmune disease; the near-term and intermediate value creation potential of its autoimmune programs; the company’s intention to preserve the value of its oncology programs; the company’s business strategies, plans and prospects, including those related to the prioritization of CUE-401 and CUE-501, and the potential benefits of the company’s program prioritization and realignment on its burn rate; and the cash runway of the company and the sufficiency of the company’s cash and cash equivalents to fund its operations. Forward-looking statements, which are based on certain assumptions and describe the company’s future plans, strategies and expectations, can generally be identified by the use of forward-looking terms such as “believe,” “expect,” “may,” “will,” “should,” “would,” “could,” “seek,” “intend,” “plan,” “goal,” “project,” “estimate,” “anticipate,” “strategy,” “future,” “likely,” “promise” or other comparable terms, although not all forward-looking statements contain these identifying words. All statements other than statements of historical facts included in this press release regarding the company’s strategies, prospects, financial condition, operations, costs, plans and objectives are forward-looking statements. Important factors that could cause the company’s actual results and financial condition to differ materially from those indicated in the forward-looking statements include, among others, the company’s ability to shift its focus to its autoimmune assets and achieve the cost savings that it is projecting; the company’s limited operating history, limited cash and a history of losses; the company’s ability to achieve profitability; potential setbacks in the company’s research and development efforts including negative or inconclusive results from its preclinical studies or clinical trials or the company’s ability to replicate in later clinical trials positive results found in preclinical studies and early-stage clinical trials of its product candidates; serious and unexpected drug-related side effects or other safety issues experienced by participants in clinical trials; its ability to secure required U.S. Food and Drug Administration (“FDA”) or other governmental approvals for its product candidates and the breadth of any approved indication; adverse effects caused by public health pandemics, including possible effects on the company’s operations and clinical trials; delays and changes in regulatory requirements, policy and guidelines including potential delays in submitting required regulatory applications to the FDA; the company’s reliance on licensors, collaborators, contract research organizations, suppliers and other business partners; the company’s ability to obtain adequate financing to fund its business operations in the future and ability to continue as a going concern; the company’s ability to maintain and enforce necessary patent and other intellectual property protection; competitive factors; general economic and market conditions and the other risks and uncertainties described in the Risk Factors and Management's Discussion and Analysis of Financial Condition and Results of Operations sections of the company’s most recently filed Annual Report on Form 10-K and any subsequently filed Quarterly Report(s) on Form 10-Q. Any forward-looking statement made by the company in this press release is based only on information currently available to the company and speaks only as of the date on which it is made. The company undertakes no obligation to publicly update any forward-looking statement, whether written or oral, that may be made from time to time, whether as a result of new information, future developments or otherwise. Investor Contact Marie Campinell Senior Director, Corporate CommunicationsCue Biopharma, Inc.mcampinell@cuebio.com Media ContactJonathan PappasLifeSci Communicationsjpappas@lifescicomms.com