Last update 01 Nov 2024

MDMX

Basic Info

Synonyms
Double minute 4 protein, HDMX, Mdm2-like p53-binding protein
+ [10]
Introduction
Along with MDM2, contributes to TP53 regulation (PubMed:32300648). Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.

Analysis

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