AT III

--CM-101's Unique Dual Anti-Fibrotic and Anti-Inflammatory Activity Supports Its Disease Modifying Potential in Primary Sclerosing Cholangitis (PSC)--- --CM-101 Phase 2 SPRING Trial in PSC is Advancing Towards Completion of Enrollment with Topline Readout Currently Targeted in Second Half of 2024-- TEL AVIV, Israel, Sept. 28, 2023 /PRNewswire/ -- Chemomab Therapeutics Ltd. (Nasdaq: CMMB), (Chemomab), a clinical stage biotechnology company developing innovative therapeutics to treat rare fibro-inflammatory diseases with high unmet need, today announced that Chemomab co-founder, Chief Executive Officer and Chief Scientific Officer Adi Mor, PhD, will discuss the CM-101 clinical program in primary sclerosing cholangitis (PSC) at the 2023 Roth MKM Healthcare Opportunities Conference on October 12, 2023. The conference is being held at the Yale Club in New York City. Dr. Mor will give a live presentation at 12:00 noon ET and company executives will participate in one-on-one meetings with investors. Chemomab's first-in-class monoclonal antibody CM-101 neutralizes CCL24, a novel target that has been shown to play a central role in the processes that drive fibrosis and inflammation. CM-101 is currently being assessed in the Phase 2 SPRING trial for the treatment of PSC, with topline data expected in the second half of 2024. PSC is a potentially lethal condition that lacks any FDA-approved therapies and frequently requires liver transplant. Unlike the other drugs in clinical development for PSC, CM-101 has a unique dual mechanism of action that simultaneously blocks fibrosis and inflammation. In extensive preclinical and early clinical studies, this distinctive, multifaceted approach has been shown to inhibit fibrogenesis and interfere with the core pathways that result in the liver damage associated with PSC. Earlier this year, Chemomab reported positive results from a Phase 2a liver fibrosis trial in patients with nonalcoholic steatohepatitis (NASH). A majority of patients treated with CM-101 demonstrated improvements in multiple biomarkers associated with fibrosis and inflammation. A higher percentage of patients responding to treatment with CM-101 had improvements in Enhanced Liver Fibrosis (ELF) scores, liver stiffness as measured by transient elastography, and PRO-C3 levels compared to placebo. The ELF score, liver stiffness as measured by transient elastography and PRO-C3, a marker of collagen III formation, have all been identified as prognostic markers and independent predictors of transplant-free survival and improved patient outcomes in PSC. These results suggest that CM-101 possesses anti-fibrotic properties in the liver that may also be relevant in PSC, and Chemomab views these data as promising for a potentially successful translation to the treatment of PSC. The company's ongoing PSC Phase 2 SPRING trial is evaluating two dose cohorts that are intended to provide high exposure to CM-101 (10 and 20mg/kg intravenously administered, compared to 5mg/kg via subcutaneous injection in the liver fibrosis/NASH trial), as well as an open-label extension providing for longer-term evaluation of the effects of CM-101 treatment for up to 48 weeks, thereby enhancing the opportunity for a more comprehensive assessment of CM-101's therapeutic potential in PSC. "We have reported a number of positive CM-101 developments this year," said Dr. Mor. "First, we reported consistent, positive biomarker data from our Phase 2 liver fibrosis trial in NASH patients that we believe are directly relevant to PSC; second, we presented several supportive preclinical PSC studies at major scientific meetings and published a peer-reviewed scientific review of the role of CCL24 in PSC; and third, the strong commitment of PSC patients and clinicians to the Phase 2 SPRING trial is enabling us to advance enrollment at a robust pace." Dr. Mor added, "We consider the recent announcement of promising results in Pliant's Phase 2 PSC study as a positive for the field, highlighting the unmet need in PSC and the possible utility of anti-fibrotic agents in this condition. Our continued clinical progress in validating CM-101's unique dual anti-inflammatory and anti-fibrotic activity reinforces our optimism that CM-101 may have potential as a disease-modifying therapy for PSC. We look forward to discussing the CM-101 PSC program at the upcoming Roth MKM conference as we advance towards completing our Phase 2 trial and reporting topline results in the coming year." Attendance at the conference is by invitation only. To register for the 2023 Roth-MKM Healthcare Opportunities Conference, click here, or contact a Roth MKM sales representative. About CM-101 CM-101 is a monoclonal antibody that neutralizes CCL24, a soluble protein that helps drive the inflammatory and fibrotic pathways central to many fibro-inflammatory diseases. CCL24's role as a therapeutic target has been validated in extensive preclinical studies and Chemomab researchers have demonstrated preclinical proof-of-concept for CM-101 in multiple animal and patient sample studies. CM-101 was safe and well tolerated in Phase 1 and Phase 2 clinical trials to date. In a Phase 1b study it improved liver biomarkers, decreased liver stiffness and demonstrated a favorable PK and target engagement profile in patients with nonalcoholic fatty liver disease (NAFLD). Data from a completed Phase 2a liver fibrosis trial in NASH patients (NCT05824156) reported earlier this year showed consistent, positive improvements in key inflammatory and fibrogenesis-related biomarkers, including several that may serve as a potential bridge to activity in PSC. CM-101 is currently being evaluated in PSC patients in the Phase 2 SPRING trial (NCT04595825), with a topline readout expected in the second half of 2024. About Chemomab Therapeutics Ltd. Chemomab is a clinical stage biotechnology company developing innovative therapeutics for fibro-inflammatory diseases with high unmet need. Based on the unique and pivotal role of CCL24 in promoting fibrosis and inflammation, Chemomab developed CM-101, a monoclonal antibody designed to neutralize CCL24 activity. In preclinical and clinical studies, CM-101 appears safe, with the potential to treat multiple severe and life-threatening fibro-inflammatory diseases. Chemomab has reported encouraging results from three clinical trials of CM-101 in patients, including a Phase 1b trial in NAFLD patients, a Phase 2 liver fibrosis trial in NASH patients and an investigator-initiated study in patients with severe lung injury. The CM-101 program for the treatment of systemic sclerosis is Phase 2-ready and a Phase 2 trial in primary sclerosing cholangitis patients is ongoing, with topline data expected in the second half of 2024. For more information about Chemomab, visit chemomab.com. Forward Looking Statements This press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act. These forward-looking statements include, among other things, statements regarding the clinical development pathway for CM-101; the future operations of Chemomab and its ability to successfully initiate and complete clinical trials and achieve regulatory milestones; the Company's cash position and expectations regarding its ability to achieve the topline data readout from the Phase 2 primary sclerosing cholangitis (PSC) trial of CM-101 with its current cash; the nature, strategy and focus of Chemomab; the development and commercial potential and potential benefits of any product candidates of Chemomab; and that the product candidates have the potential to address high unmet needs of patients with serious fibrosis-related diseases and conditions. Any statements contained in this communication that are not statements of historical fact may be deemed to be forward-looking statements. These forward-looking statements are based upon Chemomab's current expectations. Forward-looking statements involve risks and uncertainties. Because such statements deal with future events and are based on Chemomab's current expectations, they are subject to various risks and uncertainties and actual results, performance or achievements of Chemomab could differ materially from those described in or implied by the statements in this presentation, including those found under the caption "Risk Factors" and elsewhere in Chemomab's filings and reports with the SEC. Chemomab expressly disclaims any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in Chemomab's expectations with regard thereto or any change in events, conditions or circumstances on which any such statements are based, except as required by law. Contacts: Media and Investors: Barbara Lindheim Consulting Vice President, Investor & Public Relations, Strategic Communications Phone: +1 917-355-9234 [email protected] [email protected] SOURCE Chemomab Therapeutics, Ltd.

Funding enables completion of ongoing Phase 1/2 study of bispecific antibody HMB-001 in Glanzmann Thrombasthenia, initiation of pivotal studies, start and conclusion of Phase 1/2 study of HMB-VWF in von Willebrand Disease, as well as future pipeline evolution. COPENHAGEN, Denmark and BOSTON, Feb. 21, 2023 /PRNewswire/ -- Hemab Therapeutics, a clinical-stage biotechnology company developing the first prophylactic therapeutics for serious, underserved bleeding and thrombotic disorders, today announced the closing of an oversubscribed $135 million Series B financing. Access Biotechnology led the round, with participation from new investors Deep Track Capital, Avoro Ventures, Invus, Rock Springs Capital, and Maj Invest Equity, as well as all current investors Novo Holdings, RA Capital Management, and HealthCap. "Hemab is fundamentally reimagining the treatment paradigm for underserved bleeding and thrombotic disorders. This financing will allow us to progress our clinical programs for the first prophylactic treatments for Glanzmann Thrombasthenia and von Willebrand Disease, delivering functional cures for patients in need," said Benny Sorensen, MD, PhD, CEO & President of Hemab. "We're grateful for this robust syndicate of investors who support our approach of leveraging validated advanced technologies and deep insights into the biology of clotting to overcome decades of scientific stagnation." The financing will support Hemab's scientific and corporate growth plans through 2025, including completion of an ongoing Phase 1/2 clinical study of lead candidate HMB-001 in Glanzmann Thrombasthenia, initiation of pivotal studies, start and completion of Phase 1/2 clinical evaluation for HMB-VWF in von Willebrand disease, and future pipeline evolution in accordance with the company's Hemab 1-2-5™ strategic guidance—targeting development of 5 clinical assets by 2025. "Strong investor confidence—in this case, an upsized round and more than $200 million in demand—is a testament to the expertise of the Hemab team, their validated scientific approach, and the opportunity to bring long-overdue innovation to patients living with severe bleeding and thrombotic diseases," said John Maraganore, PhD, Chair of Hemab's Board of Directors. "As founding investor and the company's largest shareholder, we are excited to support Hemab in the next phase of its plan to build the ultimate clotting company, with a Nordic foundation and global footprint," said Jørgen Søberg Petersen, MD, PhD, MBA, Partner at Novo Holdings. Hemab also announced Dan Becker, MD, PhD, Managing Director at Access, and Uya Chuluunbaatar, PhD, Partner at Avoro Ventures, will also join as Directors. Christine Borowski, PhD, Vice President at Access, will join as a Board Observer. "We are thrilled to partner with Hemab's exceptional leadership to advance a pipeline of transformative new medicines for areas of high unmet need in hemostatic disorders," said Dr. Becker. About Hemab Therapeutics Hemab is a clinical-stage biotech company developing the first prophylactic therapeutics for serious, underserved bleeding and thrombotic disorders. Based in the US and Denmark, Hemab is progressing a pipeline of monoclonal and bispecific antibody-based therapeutics to transform the treatment paradigm for patients with high unmet need. The company's strategic guidance, Hemab 1-2-5TM, targets the development of 5 clinical assets by 2025 to deliver long-awaited innovation for patients with Factor VII Deficiency, Bernard Soulier Syndrome, Von Willebrand Disease, Hereditary Hemorrhagic Telangiectasia (or Osler-Weber-Rendu disease), Congenital Antithrombin III Deficiency, and other serious disorders. Learn more at hemab.com. About HMB-001 HMB-001 is bispecific antibody that binds and stabilizes endogenous factor VIIa (FVIIa) with one antibody arm and TLT-1 on activated platelets with the other arm. This allows for accumulation of FVIIa in the body, recruitment of FVIIa directly to the surface of the activated platelets where it is known to facilitate clotting, and avoidance of clotting activity in the absence of tissue damage. HMB-001 was designed to be a first-in-class prophylactic treatment for Glanzmann Thrombasthenia with potential for other debilitating rare bleeding disorders. It entered Phase 1/2 clinical evaluation in late 2022, with initial data expected 2H 2023. SOURCE Hemab Therapeutics

COPENHAGEN, Denmark and BOSTON, Jan. 10, 2023 /PRNewswire/ -- Hemab Therapeutics, a clinical-stage biotechnology company developing next-generation therapeutics for serious, underserved bleeding and thrombotic disorders, today announced the first patient has been dosed in a Phase 1/2 study evaluating HMB-001 for the treatment of the severe bleeding disorder Glanzmann Thrombasthenia (Glanzmann). The update was provided during a corporate overview presented at the 41st Annual J.P. Morgan Healthcare Conference held this week in San Francisco. HMB-001 is a bispecific antibody that binds, stabilizes, and recruits endogenous factor VIIa (FVIIa) to the site of vascular injury to overcome the body's inability to form healthy clots. "HMB-001 is the first candidate of our emerging pipeline to reach clinical stage as we realize our mission to deliver functional cure medicines to people living with serious blood clotting disorders," said Benny Sorensen, MD, PhD, CEO of Hemab. "This milestone is supported by preclinical data showing HMB-001 potentiates FVIIa-dependent fibrin formation on platelets in Glanzmann and accumulates FVIIa to levels that are considered therapeutically effective. We are confident clinical evaluation will confirm HMB-001's potential and look forward to its continued clinical advancement as the first prophylaxis treatment for Glanzmann and other severe bleeding disorders." The Phase 1/2 first-in-human open-label study in patients with Glanzmann was designed to evaluate HMB-001 for safety, tolerability, biomarkers such as FVII levels and bleeding time before and after HMB-001, and efficacy based on assessment of changes in bleeding frequency. Facilitated in collaboration with the UK-based clinical research organization Richmond Pharmacology, the trial is expected to expand into the US and other EU countries. Initial data are expected 2H 2023. "Many patients with Glanzmann suffer from frequent and potentially life-threatening bleed events. Despite that, we have concerningly few effective and no prophylactic treatment options to offer them, often relying on platelet transfusions, antifibrinolytics, or acute use of recombinant factor VIIa," said Suthesh Sivapalaratnam, MD, PhD MRCP FRCPath, Consultant of Paediatric and Adult Haemostasis and Thrombosis at The Royal London Hospital, Barts Health NHS Trust. "I am eager to see HMB-001 progress through clinical evaluation toward validating its potential as a much-needed bleed-preventative treatment for patients with Glanzmann all over the world." In partnership with UK specialist research consultancy Haemnet, Hemab announced in mid-2022 that it had commenced a natural history study to better understand the realities of living with Glanzmann and expects to share new data from the study in early 2023. The company is continuing to advance its strategic guidance, Hemab 1-2-5™, to develop five clinical assets by 2025 to transform treatment for rare bleeding and thrombotic disorders with high unmet need, including Glanzmann, Factor VII Deficiency, Bernard Soulier Syndrome, Von Willebrand Disease, Hereditary Hemorrhagic Telangiectasia (or Osler-Weber-Rendu disease), Congenital Antithrombin III Deficiency. About Hemab Therapeutics Hemab is a clinical-stage biotech company developing next generation therapeutics for serious, underserved bleeding and thrombosis disorders. Based in Denmark and the US and backed by Novo Holdings, RA Capital, and HealthCap, Hemab aims to progress its pipeline of monoclonal and bispecific antibody-based therapeutics with the vision of transforming the treatment paradigm for patients with bleeding and thrombotic disorders with high unmet need. Learn more at hemab.com. About HMB-001 HMB-001 is bispecific antibody that binds and stabilizes endogenous factor VIIa (FVIIa) with one antibody arm and TLT-1 on activated platelets with the other arm. This allows for accumulation of FVIIa in the body, recruitment of FVIIa directly to the surface of the activated platelets where it is known to facilitate clotting, and avoidance of clotting activity in the absence of tissue damage. HMB-001 was designed to be a first-in-class prophylactic treatment for Glanzmann Thrombasthenia with potential for other debilitating rare bleeding disorders. It entered Phase 1/2 clinical evaluation in late 2022, with initial data expected 2H 2023. SOURCE Hemab Therapeutics