A Phase 2a, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety, Tolerability and Efficacy of MTR-601, a Novel Oral Treatment in Patients With Cervical Dystonia

Study MTR-601-201 is an 8-week, randomized, placebo-controlled study to examine the safety, tolerability, and efficacy of MTR-601 in participants with cervical dystonia.

Start Date28 Feb 2025

Sponsor / Collaborator

Motric Bio

NCT06117020

/ CompletedPhase 1

A Randomized, Double-Blind, Placebo-Controlled, First-in-Human, Single and Multiple Ascending Dose Study of MTR-601 in Healthy Volunteers.

To assess the safety and tolerability of single and multiple doses of MTR-601 in normal healthy volunteers under fed and fasted conditions.
To evaluate the plasma and urine pharmacokinetics (PK) of MTR-601. To evaluate the pharmacodynamic (PD) effects of MTR-601 on muscle strength and muscle accumulation of MTR-601 by muscle biopsy and other potential mechanistic, predictive and PD markers of MTR-601.

Start Date11 Sep 2023

Sponsor / Collaborator

Motric Bio

100 Clinical Results associated with MYH2

100 Translational Medicine associated with MYH2

0 Patents (Medical) associated with MYH2

857

Literatures (Medical) associated with MYH2

01 Mar 2025·Ear, Nose & Throat Journal

Heterozygous MYH9 Mutations in 2 Children With Cochlear Nerve Canal Stenosis

Article

Author: Han, Shuguang ; Peng, Kevin A. ; Zheng, Wenrui ; Wang, Line ; Liang, Wenqi

MYH9 is a gene that encodes for a subunit of the myosin heavy chain IIA protein. Mutations in MYH9 are associated with hematologic abnormalities, renal dysfunction, and hearing loss. Bony cochlear nerve canal stenosis (CNCS), which is diagnosed on computed tomography (CT) imaging, has been associated with congenital deafness, cochlear nerve aplasia/hypoplasia, and inner ear malformations. We report two cases of CNCS presenting with profound congenital hearing loss whom we diagnosed with mutations in MYH9 and discuss the genotype-phenotype association and implications for management.

01 Feb 2025·Food Chemistry

Proteomic analysis of wild boar meat: Effect of storage method and time on muscle protein stability

Article

Author: Stachniuk, Anna ; Fornal, Emilia ; Montowska, Magdalena ; Kasałka-Czarna, Natalia

Oxidation processes affect proteins from various molecular pathways and are crucial for wild boar meat quality, shelf life and human health. This study investigated the effects of different storage methods on the formation and composition of oxygen-induced protein aggregates in the muscles of European wild boar (Sus scrofa scrofa). Vacuum packaging (VAC), modified atmosphere packaging (MAP) and dry-ageing (DA) were compared over a 21-day storage period. The results showed significant differences in protein aggregation depending on the method and storage time. The most intense protein aggregation occurred in the MAP (80 % O₂), while air DA (20.9 % O₂) resulted in intermediate levels of protein aggregation. Crucial myofibrillar proteins involved in aggregate formation were titin, myosin isoforms (MYH1, MYH2 and MYH7) and nebulin, which were cross-linked with small sarcoplasmic enzymes, such as muscle creatine kinase, isocitrate dehydrogenase and ATPase 1. High‑oxygen storage conditions also promoted the oxidation of ATP synthase, beta-enolase 3, ADP/ATP translocase and myoglobin.

01 Jan 2025·Journal of Animal Science and Technology

Drone pupae extract enhances Hanwoo myosatellite cell function for cultivated meat production

Article

Author: Park, Sanghun ; Choi, Nayoung ; Lee, Sol-Hee ; Choi, Jungseok ; Oh, Sehyuk ; Lee, Junsoo ; Kim, Hyoyoung ; Bang, Geul ; Park, Gyutae

In this study, we analyzed effects of drone pupae aqueous extract powder (DEP) on proliferation and differentiation of Hanwoo myosatellite cells (HSC). Results of amino acid, vitamin, and mineral analysis of drone pupae revealed the presence of branched-chain amino acids, Glu, essential amino acids, vitamins B6, C and Mg, K, and so on. Additionally, drone pupae were shown to have an antioxidant ability. HSC were cultured for proliferation by adding 0, 10, 100, 200, and 400 μg/mL DEP to the medium. As a result of MTS analysis, DEP increased the proliferation capacity of HSC, with cell viability being significantly higher after treatment with DEP, especially when DEP was used at 100 μg/mL (p < 0.05). To measure the differentiation ability of HSC, 0 and 100 μg/mL DEP (CON, D100) were added to the medium, and cells were cultured. Myotube formation was confirmed through images using immunofluorescence staining. Fusion index and myotube area in the D100 were higher than those in the CON (p < 0.01). DEP promoted differentiation ability and myotube formation by increasing the expression of MYH2, MYOG, and DES genes and MYH2 and DES proteins in HSC. Additionally, in HSC differentiation culture, proteome expression intensity was higher in D100 than in CON. Proteins upregulated in the D100 group included Myosin, IL18, MYO1D, and so on. In conclusion, characteristics of various components present in DEP could improve the proliferation and differentiation ability of HSC. This suggests that drone pupae can be used as a functional substance to enhance muscle growth.

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