MAGL

The prevalence of Epilepsy has been rising over the past few years, which prompts the growing demand for treatment options. The increasing prevalence of Epilepsy and the growing research and development activities to develop novel therapies to treat Epilepsy to drive the market. The companies developing the potential therapies in the last stage of development include Xenon Pharmaceuticals, Engage Therapeutics, Janssen Biotech, and several others LAS VEGAS, April 11, 2023 /PRNewswire/ -- DelveInsight's ' Epilepsy Pipeline Insight – 2023 ' report provides comprehensive global coverage of available, marketed, and pipeline epilepsy therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the epilepsy pipeline domain. Key Takeaways from the Epilepsy Pipeline Report DelveInsight's epilepsy pipeline report depicts a robust space with 70+ active players working to develop 75+ pipeline therapies for epilepsy treatment. Key epilepsy companies such as Alexza Pharmaceuticals, Xenon Pharmaceuticals, GW Pharmaceuticals, Equilibre Biopharmaceuticals, Takeda Pharmaceuticals, Abide therapeutics, Otsuka pharmaceutical, H. Lundbeck A/S, Spark Therapeutics, Equilibre Biopharmaceuticals, ES Therapeutics, Supernus Pharmaceuticals, Inc., MGC Pharmaceuticals, Engrail Therapeutics INC, SK biopharmaceuticals, Longboard Pharmaceuticals, Janssen Research & Development, LLC, Equilibre Biopharmaceuticals, Cerevel Therapeutics, LLC, Neurona Therapeutics, Praxis Precision Medicines, UCB Pharma, Receptor Life Sciences, NeuroPro Therapeutics, Inc., Avicanna, Amring Pharmaceuticals Inc., Ovid Therapeutics, Addex Therapeutics, IAMA Therapeutics, CODA Biotherapeutics, Cerebral Therapeutics, Engrail Therapeutics, and others are evaluating new epilepsy drugs to improve the treatment landscape. Promising epilepsy pipeline therapies in various stages of development include Alprazolam, XEN1101, XEN-496, XEN 901, GWP42006, EQU-001, TAK-935, Lu AG06466, OPC-214870, CG 01, EQU-001, ES-481, SPN-817, MGCND00EP1, NBI 827104, ENX-101, Cenobamate, SKL-24741, LP-352, JNJ-40411813, EQU-001, CVL-865, NRTX 1001, PRAX 628, Padsevonil, RLS103, NPT 2042, AVCN-319302, PRAX-020, AMZ002, OV 350, IAMA-6, CT-010, ENX-101, and others. In March 2023, IAMA Therapeutics, a preclinical-stage pharmaceutical company focused on the discovery, development, and commercialization of novel medicines to make a difference in the lives of individuals suffering from brain disorders, announced that preclinical data supporting its IAMA-6 program in focal refractory epilepsy will be presented at the 75th American Academy of Neurology (AAN) Annual Meeting, taking place on April 22-27 in Boston, Massachusetts. In February 2023, Addex Therapeutics announced that enrollment into Part 1 of Phase 2 clinical study of ADX71149 (JNJ-40411813) for the treatment of epilepsy had been completed. ADX71149 is a selective metabotropic glutamate type 2 (mGlu2) receptor-positive allosteric modulator (PAM). Janssen Pharmaceuticals, Inc., part of the Janssen Pharmaceutical Companies of Johnson & Johnson, is conducting the trial. In January 2023, Equilibre Biopharmaceuticals Corp., reported positive topline results from the Phase 2 clinical trial evaluating the clinical safety, tolerability, and preliminary efficacy of EQU-001 – a novel anti-inflammatory anti-seizure medication - administered as once-daily oral adjunctive therapy for focal seizures in adults with epilepsy. The results of the EQU-001 study are encouraging because they demonstrate impressive tolerability and encouraging efficacy for adult patients with focal epilepsy, especially for those with seizures that are difficult to treat. In January 2023, Signant Health, introduced a novel electronic diary (eDiary) data capture solution designed to simplify the experience for patients and research sites participating in epilepsy trials while ensuring robust outcome assessment data to support trial endpoints. Developed in collaboration with The Epilepsy Study Consortium (TESC), the new patient-reported outcome measure offers clinical research sponsors and organizations a standardized solution to capture common seizure data elements with high-quality data. In June 2022, CODA Biotherapeutics, Inc. announced that preclinical data from the Company's focal epilepsy program demonstrated that treatment with the Company's lead-engineered receptor and small molecule activator drug significantly reduced focal seizure frequency in vivo. Results showed that the rapid reduction in seizures is consistent with the pharmacokinetics of the activator drug in mouse models. Data also demonstrated that the expression of CODA's lead receptor is highly correlated with a reduction in seizure frequency. In September 2022, Avicanna Inc. was pleased to announce that it has expanded its research collaboration in the field of Epilepsy with a new collaboration with the University of Toronto and Dr. Mac Burnham's research team to explore the efficacy of Avicanna's proprietary formulations in pre-clinical models for Epilepsy. The research collaboration led by Dr. Mac Burnham's team will explore the efficacy of Avicanna's drug candidates, including AVCN319302, in animal models for Epilepsy. In December 2022, Praxis Precision Medicines, Inc. and UCB announced a strategic collaboration, based upon Praxis' PRAX-020 program, for the discovery of small molecule therapeutics as potential treatments of KCNT1-related epilepsies. Under the terms of the collaboration, UCB retains an exclusive option to in-license global development and commercialization rights to any resulting KCNT1 small molecule development candidate. In January 2022, Ovid Therapeutics Inc. announced the company has entered into an exclusive license agreement with AstraZeneca for a library of early-stage small molecules targeting the KCC2 transporter, including lead candidate OV350. The company seeks to optimize and accelerate the development of these KCC2 transporter activators in epilepsies and potentially other neuropathic conditions. In August 2021, Marinus Pharmaceuticals, Inc. announced that it has entered into an agreement with Orion Corporation whereby Orion received exclusive rights to commercialize the oral and intravenous (IV) dose formulations of ganaxolone in the European Economic Area, United Kingdom, and Switzerland for CDKL5 deficiency disorder (CDD), tuberous sclerosis complex (TSC) and refractory status epilepticus (RSE). Request a sample and discover the recent advances in epilepsy drug treatment @ Epilepsy Pipeline Report The epilepsy pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage epilepsy drugs, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the epilepsy clinical trial landscape. Epilepsy Overview Epilepsy is a chronic condition characterized by unprovoked, recurrent seizures. A seizure is an uncontrollable surge of electrical activity in the brain. Seizures are classified into two types. Seizures that affect the entire brain are known as generalized seizures. Focal seizures, also known as partial seizures, affect only one part of the brain. A mild seizure can be difficult to detect. It can last a few seconds, and you are unaware of it. Stronger seizures, lasting from a few seconds to several minutes, can cause spasms and uncontrollable muscle twitches. Epilepsy symptoms vary according to the area of the brain where seizure activity occurs and the type of seizure. Epilepsy symptoms may include: stiff muscles, Become stiff and falling backward, muscles relaxing and going floppy, confusion, breathing becomes difficult, unconscious, visual disturbances/hallucinations, uncontrollable jerking and shaking, called a "fit," losing awareness and staring blankly into space, strange sensations, such as a "rising" feeling in the tummy, unusual smells or tastes, and a tingling feeling in your arms or legs and collapsing. Epilepsy treatment can help most people with epilepsy have fewer seizures or completely stop having seizures. Find out more about drugs for epilepsy @ New Epilepsy Drugs A snapshot of the Epilepsy Pipeline Drugs mentioned in the report: Learn more about the emerging epilepsy pipeline therapies @ Epilepsy Clinical Trials Epilepsy Therapeutics Assessment The epilepsy pipeline report proffers an integral view of epilepsy emerging novel therapies segmented by stage, product type, molecule type, mechanism of action, and route of administration. Scope of the Epilepsy Pipeline Report Coverage: Global Therapeutic Assessment By Product Type: Mono, Combination, Mono/Combination Therapeutic Assessment By Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III Therapeutics Assessment By Route of Administration: Intra-articular, Intraocular, Intrathecal, Intravenous, Ophthalmic, Oral, Parenteral, Subcutaneous, Topical, Transdermal Therapeutics Assessment By Molecule Type: Oligonucleotide, Peptide, Small molecule Therapeutics Assessment By Mechanism of Action: KCNQ potassium channel agonists, Monoacylglycerol lipase inhibitors, Cholesterol 24-hydroxylase inhibitors, NMDA receptor modulators, AMPA receptor antagonists, GABA A receptor agonists, Cannabinoid receptor modulators Key Epilepsy Companies: Alexza Pharmaceuticals, Xenon Pharmaceuticals, GW Pharmaceuticals, Equilibre Biopharmaceuticals, Takeda Pharmaceuticals, Abide therapeutics, Otsuka pharmaceutical, H. Lundbeck A/S, Spark Therapeutics, Equilibre Biopharmaceuticals, ES Therapeutics, Supernus Pharmaceuticals, Inc., MGC Pharmaceuticals, Engrail Therapeutics INC, SK biopharmaceuticals, Longboard Pharmaceuticals, Janssen Research & Development, LLC, Equilibre Biopharmaceuticals, Cerevel Therapeutics, LLC, Neurona Therapeutics, Praxis Precision Medicines, UCB Pharma, Receptor Life Sciences, NeuroPro Therapeutics, Inc., Avicanna, Amring Pharmaceuticals Inc., Ovid Therapeutics, Addex Therapeutics, IAMA Therapeutics, CODA Biotherapeutics, Cerebral Therapeutics, Engrail Therapeutics, and others. Key Epilepsy Pipeline Therapies: Alprazolam, XEN1101, XEN-496, XEN 901, GWP42006, EQU-001, TAK-935, Lu AG06466, OPC-214870, CG 01, EQU-001, ES-481, SPN-817, MGCND00EP1, NBI 827104, ENX-101, Cenobamate, SKL-24741, LP-352, JNJ-40411813, EQU-001, CVL-865, NRTX 1001, PRAX 628, Padsevonil, RLS103, NPT 2042, AVCN-319302, PRAX-020, AMZ002, OV 350, IAMA-6,CT-010, ENX-101, and others. Dive deep into rich insights for new drugs for epilepsy treatment; visit @ Epilepsy Medications Table of Contents For further information on the epilepsy pipeline therapeutics, reach out @ Epilepsy Drug Treatment Related Reports Epilepsy Market Epilepsy Market Insights, Epidemiology, and Market Forecast – 2032 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key epilepsy companies including Takeda Pharmaceuticals, Abide therapeutics, Otsuka pharmaceutical, among others. Epilepsy Epidemiology Forecast Epilepsy Epidemiology Forecast – 2032 report delivers an in-depth understanding of the disease, historical and forecasted epilepsy epidemiology in the 7MM, i.e., the United States, EU5 (Germany, Spain, Italy, France, and the United Kingdom), and Japan. Refractory Epilepsy Pipeline Refractory Epilepsy Pipeline Insight – 2023 report provides comprehensive insights about the pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the key refractory epilepsy companies, including Eisai Co.LTD., Alexza Pharmaceuticals, Xenon Pharmaceuticals, among others. Partial Epilepsy Pipeline Partial Epilepsy Pipeline Insight – 2023 report provides comprehensive insights about the pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the key partial epilepsy companies, including GW Pharmaceuticals, Equilibre Biopharmaceuticals, among others. Refractory Epilepsy Market Refractory Epilepsy Market Insights, Epidemiology, and Market Forecast – 2032 report deliver an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key refractory epilepsy companies including Eisai Co.LTD., Alexza Pharmaceuticals, Xenon Pharmaceuticals, among others. Partial Epilepsy Market Partial Epilepsy Market Insights, Epidemiology, and Market Forecast – 2032 report deliver an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key partial epilepsy companies, including GW Pharmaceuticals, Equilibre Biopharmaceuticals, among others. 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Research Roundup for February 18 When the media and many biopharma companies and public health experts discuss waning immunity after COVID-19 vaccines, they are largely talking about decreasing numbers of antibodies. That’s not unusual — antibody titers always peter out. Usually, it is normal that while antibody levels drop, the immune system fine-tunes its antibodies, so they are of higher quality. And that’s what appears to be happening with the COVID-19 vaccines. For that and more research news, continue reading. Antibodies Improve in Quality At Least 6 Months After COVID-19 Vaccination For at least a year, we have been exposed to study after study suggesting that immunity from vaccines wanes only months after receiving COVID-19 vaccinations. In fact, this is almost entirely the rationale for booster doses, even though it largely ignores the role of memory B and T cells in the immune system. A study from Washington University School of Medicine reports that for at least six months after vaccination for COVID-19, antibodies produced by immune cells become steadily higher in quality, meaning stronger and more precisely targeted against SARS-CoV-2. This is not a new concept among immunologists or vaccine makers. The research was published in the journal Nature . “If the virus didn’t change, most people who got two doses of this vaccine would be in very good shape,” said senior author Ali Ellebedy, an associate professor of pathology & immunology, of medicine and of molecular microbiology at WU. “The antibody response we saw is exactly what we’d expect from a robust immune response. We never thought that six months following that second injection, many people would still be actively improving the quality of their antibodies. To me, that is remarkable. The problem is that this virus keeps evolving and producing new variants. So, the antibodies are getting better at recognizing the original strain, but unfortunately, the target keeps changing.” They collected blood from 42 people, and lymph node samples from 15 people before each received their first dose of the Pfizer - BioNTech vaccine and at weeks three, four, five, seven, 15 and 29. They also collected bone marrow samples from 11 participants 29 and 40 weeks after the first shot. They found that B cells targeting SARS-COV-2 persisted in the germinal centers of all the people for months. Even six months after vaccination, 10 of 15 had B cells in their germinal centers, which are areas where B cells are trained to manufacture increasingly better-quality antibodies. This was also a surprise because germinal centers are usually thought to last only a few weeks, but they were still present six months later in two-thirds of their participants after receiving the vaccine. In one set of experiments, they found that almost 80% of antibodies bound to the viral protein six months later compared to about 20% of the earlier antibodies. Ellebedy noted, “When you look at antibodies, quantity should not be your only concern. The antibodies at six months might be less in quantity, but they are much better in quality.” He went on to say, “Everything changes when a new variant comes. You have to retrain your immune system. It’s like updating your anti-malware software to make sure it matches the newest computer viruses that are going around. It doesn’t mean the old software was bad. It just means it no longer completely matches the viruses it is going to encounter.” Enzyme May Boost Neuroprotection in the Brain Astrocytes are star-shaped cells in the brain that play a key role in brain immune response. Astrocyte degradation is implicated in Alzheimer’s and other neurodegenerative diseases, as well as in traumatic brain injury (TBI). Researchers at the University of Texas Health Science Center at San Antonio demonstrated that when an enzyme called monoacylglycerol lipase (MAGL) is deactivated in mice, there is decreased neuropathology and improved cognitive function in TBI. Typically, MAGL degrades a neuroprotective molecule called 2-arachidonoylglycerol (2-AG), reducing its ability to help the brain. 2-AG metabolism in astrocytes promotes neuropathology but doesn’t do that in neurons. They believe targeting inhibition of 2-AG degradation could be beneficial for treating certain forms of neurodegeneration. A Link Between Age-related Cognitive Disorders and Mitochondrial Dysfunction Investigators with Shibaura Institute of Technology in Japan identified a link between mitochondrial dysfunction and age-related cognitive disorders. Working with mice models of Alzheimer’s disease (AD), they identified differences in how the mice performed on specific well-known experiments, the Morris water maze and the Rota-rod test. The AD mice took longer to complete the maze but didn’t slow down; in the Rota-rod test, the 6- and 20-month-old AD mice stayed on the rod longer, while age-matched control mice fell quicker. To determine the differences in AD-related proteins in the two groups of mice, they collected tissue samples from different parts of the mice’s brains and evaluated oxidative markers. They found that AD mice had higher levels of beta-amyloid, which was not particularly surprising. What was surprising was the AD-related beta amyloid1-42 was significantly higher in the hippocampus than in other parts of the brain. They didn’t observe any changes in the levels of the tau protein, another abnormal protein associated with AD. The beta amyloid1-42 aggregation in the hippocampus caused cognitive impairment in the AD mice. They then evaluated key mitochondrial oxidative enzymes, including nicotinamide-nucleotide adenylyltransferase (NMNAT)-3, which shows anti-aging effects. When NMNAT-3 was decreased, levels of 3-NT (3-nitrotyrosine), an indicator of higher oxidation, increased with age in AD mice. They concluded that decreased levels of NMNAT-3 and higher levels of 3-NT were evidence that oxidation causes mitochondrial dysfunction, which leads to cognitive dysfunction. New Class of Compounds Shows Promise in Treating Diabetes and Metabolic Syndrome Researchers at Washington University School of Medicine in St. Louis demonstrated that a new class of compounds improves several aspects of metabolic syndrome. Metabolic syndrome is a catch-all phrase that includes type 2 diabetes, high cholesterol, fatty liver and excess body fat. Evaluating a compound dubbed SN-401, they found it treated diabetes by improving the pancreas’s ability to secrete insulin while increasing the capacity of other tissues to utilize that insulin. By fine-tuning the compound, they created a class of related compounds based on a key protein called SWELL1 (also LRRC8a). They published their research in Nature Communications . “This protein, SWELL1, has a sort of dual personality,” said senior author Dr. Rajan Sah, associate professor of medicine at WU. “The compound binds to SWELL1 in a manner that stabilizes the protein complex so as to enhance expression and signaling across multiple tissues, including adipose, skeletal muscle, liver, the inner lining of blood vessels, and pancreatic islet cells. This restores both insulin sensitivity across tissue types and insulin secretion in the pancreas.” The compound did not seem to affect the blood sugar in healthy mice, a useful aspect for possible therapy in people. Working in mice, the compound improved insulin sensitivity and secretion and improved blood sugar levels and decreased the fat buildup in the liver.

With a $250 million cash down payment, Denmark’s H. Lundbeck A/S snapped up San Diego-based Abide Therapeutics to gain a novel discovery platform and a U.S.-based research hub. With a $250 million cash down payment , Denmark’s H. Lundbeck A/S snapped up San Diego-based Abide Therapeutics to gain a novel discovery platform and a U.S.-based research hub. Deborah Dunsire, president and chief executive officer of Lundbeck said the acquisition of Abide provides the company with a “differentiated chemo-proteomic platform to discover new classes of drugs for a broad spectrum of brain diseases starting with those that harness the therapeutic potential of the endocannabinoid system.” Dunsire said Abide’s research and development program provides both an immediate and long-term boost to its pipeline. Bringing Abide under the Lundbeck portfolio puts the Danish company in a position to deliver multiple new and transformative treatments for brain diseases, Dunsire said in a statement. In its announcement, Lundbeck did not provide details regarding the 40 employees at Abide, including its leadership team. Kevin Finney , who joined Abide in January as president and chief operating officer, told Xconomy that the company had actually been in the midst of a financing round and eying an initial public offering when the Lundbeck offer came along. The deal was too good to pass up, Finney said, according to the report. Abide Chief Executive Officer Alan Ezekowitz noted Lundbeck’s commitment to developing therapies for the brain and said it was that expertise that convinced the company’s board of directors to support the deal. Lundbeck, he said, “was the best way to attain Abide’s goal to develop novel therapeutics that make a fundamental difference in the lives of patients with a range of neurological and mood disorders.” Ezekowitz added that Lundbeck’s support for the La Jolla discovery site means that we can continue to leverage the insights of co-founder Ben Cravatt’s laboratory at Scripps Research and maintain its “outstanding discovery team.” What attracted Lundbeck to acquiring Abide is that company’s lead molecule, ABX-1431. Abide’s ABX-1431 is a potent selective inhibitor of the serine hydrolase monoacylglycerol lipase (MGLL). ABX-1431 is designed to increase the power of endocannabinoid signaling to restore homeostatic balance in the central nervous system. The company believes it has the potential to address multiple indications in psychiatry and neurology. ABX-1431 is currently in an exploratory Phase IIa trial for the treatment of Tourette syndrome and a Phase I trial for neuropathic pain. In addition to the clinical and pre-clinical programs targeting MGLL, Abide has a rich pipeline of inhibitors targeting other serine hydrolases that may be pursued as future novel treatments. In addition to the $250 million paid upfront to Abide, Lundbeck will also pay an additional $150 million in future development and sales milestones. After the deal closes, Abide’s laboratory in La Jolla will become a U.S. drug discovery hub for Lundbeck. Lundbeck is covering the costs of the acquisition of Abide from its existing cash reserves. The transaction is expected to close during the second quarter of 2019. Lundbeck said the deal will not have any impact on Lundbeck’s 2019 financial guidance range provided in February 2019.