The study is a double-blind randomized, placebo controlled trial examining the impact of perioperative bupivacaine nerve block on PACU recovery metrics. Patients with operative facial fractures are randomized to receive either bupivacaine or saline injections prior to the anesthesia emergence.

Start Date02 Apr 2024

Sponsor / Collaborator

Washington University School of Medicine

NCT05908305 / Not yet recruitingPhase 4IIT

Study of Tramadol Addiction Impact on Dental Anesthesia Succes.

The aim is to investigate and to find a correlation between tramadol addiction misuse among Algerian males and Dental Local Anesthesia success while performing dental care and oral surgeries.

Start Date10 Jun 2023

Sponsor / Collaborator

The University of Algiers

NCT05804630 / Enrolling by invitationNot ApplicableIIT

Efficacy and Safety of Articaine and Lidocaine in Extraction of Wisdom Teeth of Upper and Lower Jaws

Local anesthesia drugs and anesthesia technique play an imperative role in dental treatment. The purpose of this study was to compare the efficacy and safety of different dental local anesthetics drugs and brands in clinical use for the extraction of wisdom teeth.

Start Date15 Mar 2023

Sponsor / Collaborator

National Taiwan University Hospital

100 Clinical Results associated with ADRA1 x SCNA x β-adrenoceptors

100 Translational Medicine associated with ADRA1 x SCNA x β-adrenoceptors

0 Patents (Medical) associated with ADRA1 x SCNA x β-adrenoceptors

Literatures (Medical) associated with ADRA1 x SCNA x β-adrenoceptors

01 Jun 2020·The American Journal of PathologyQ2 · MEDICINE

Sympathetic Nerves Positively Regulate Eosinophil-Driven Allergic Conjunctivitis via α1-Adrenergic Receptor Signaling

Q2 · MEDICINE

Article

Author: Huang, Shuoya ; He, Jingxin ; Wang, Yuming ; Yu, Ruoxun ; Xue, Yunxia ; Chen, Xinwei ; Li, Zhijie ; Wu, Mingjuan ; Liu, Jun ; Fu, Ting ; Li, Fanying

Eosinophils are a major cause of tissue injury in allergic conjunctivitis. The biological nature of eosinophils in the conjunctiva and the mechanisms that control eosinophils' responses in allergic conjunctivitis are currently not completely understood. This study reports that conjunctival eosinophils comprise two populations-Siglec-F^int and Siglec-F^hi-in different life stages. Siglec-F^int eosinophils partly expressed CD34 and were in the immature (or steady) state. Siglec-F^hi eosinophils did not express CD34, sharply increased in number after short ragweed (SRW) pollen challenge, and were in the mature (or activated) state. Moreover, chemical sympathectomy by 6-hydroxydopamine reduced the recruitment and activation of eosinophils, whereas the activation of the sympathetic nerve system (SNS) with restraint stress accelerated the recruitment and activation of eosinophils in SRW-induced conjunctivitis. It was also found that two eosinophil populations expressed alpha-1a-adrenergic receptors (α1a-ARs); in SRW-induced conjunctivitis, treatment with an α1a-AR antagonist decreased eosinophil responses, whereas treatment with an α1a-AR agonist aggravated eosinophil responses. Thus, eosinophil responses in conjunctivitis are regulated by the SNS via α1a-AR signaling. SNS inputs or α1a-AR function may be potential targets for the treatment of allergic conjunctivitis.

01 Nov 2000·Journal of the Formosan Medical Association = Taiwan yi zhiQ3 · MEDICINE

Brugada syndrome without mutation of the cardiac sodium channel gene in a Taiwanese patient.

Q3 · MEDICINE

ArticleOA

Author: Kuo, C T ; Chiang, F T ; Lin, K H ; Chen, S M

We describe a 45-year-old Taiwanese man with specific features of Brugada syndrome but no clinical features of structural heart disease. He was successfully treated with an implantable cardioverter-defibrillator. His electrocardiogram (ECG) patterns changed intermittently. Alpha-adrenoceptor stimulation and beta-adrenoceptor blockade augmented the characteristic ST-segment elevation, whereas alpha-adrenoceptor blockade and beta-adrenoceptor stimulation mitigated the ST-segment elevation. Intravenous procainamide administration did not aggravate ST-segment elevation when ECG had shown coved ST elevation in the right precordial leads. Molecular study did not reveal the same mutations in the cardiac sodium channel gene (SCN5A) as previously reported in Brugada syndrome. This case demonstrates the genetic heterogeneity of SCN5A in Brugada syndrome.

01 Jan 1990·European Journal of PharmacologyQ3 · MEDICINE

Non-adrenergic sympathetic vasoconstriction in the eye and some other facial tissues in the rabbit

Q3 · MEDICINE

Article

Author: Siv F.E. Nilsson ; Elisabet Granstam

The effects of unilateral sympathetic nerve stimulation (SNS) on regional blood flow in the rabbit were studied with radioactive microspheres. SNS at 10 or 4 Hz caused an approximately 60% reduction in choroidal blood flow, which was partly resistant to alpha-adrenoceptor blockade with phenoxybenzamine. The vasoconstriction evoked by SNS at 2 Hz was completely abolished by alpha-adrenoceptor blockade. A similar response was seen in the iris, ciliary body, masseter muscle and lacrimal gland. In the harderian gland, however, SNS (2 Hz) after alpha-adrenoceptor blockade caused a significant reduction in blood flow. In the salivary glands, combined beta- and alpha-adrenoceptor blockade with propranolol and phenoxybenzamine revealed a slight non-adrenergic vasoconstriction during SNS at 10 Hz; however, the blood flow was significantly increased during SNS at 4 and 2 Hz following alpha-adrenoceptor blockade. These results indicate that there is a frequency-dependent, non-adrenergic component in the sympathetic vasoconstriction of the eye and several facial tissues. In the salivary glands, beta-adrenoceptor-mediated vasodilatation tends to mask a non-adrenergic vasoconstriction.

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