Last update 01 Nov 2024

Cytokine receptors x ELA2

Last update 01 Nov 2024

Basic Info

Related Targets

Cytokine receptorsELA2

Drugs associated with Cytokine receptors x ELA2

SPHD-400

Target

Cytokine receptors x ELA2

Mechanism

Cytokine receptors antagonists [+1]

Active Org.-

Originator Org.

Sinclair Pharma Ltd.

Active Indication-

Inactive Indication

Psoriasis

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with Cytokine receptors x ELA2

100 Translational Medicine associated with Cytokine receptors x ELA2

0 Patents (Medical) associated with Cytokine receptors x ELA2

167

Literatures (Medical) associated with Cytokine receptors x ELA2

01 Oct 2024·Cell Stem Cell

Vasopressin drives aberrant myeloid differentiation of hematopoietic stem cells, contributing to depression in mice

Article

Author: Li, Jinglin ; Chen, Xuequn ; Lv, Kaosheng ; Zhang, Qi ; Feng, Ye ; Chen, Siying ; Lu, Xinjiang ; Mou, Rong ; Yang, Yue ; Chen, Qiuli ; Li, Yue ; Liang, Tingbo ; Shang, Tongyao ; Ma, Junkai ; Wu, Yixin ; Ju, Xuan

Psychological stress is often linked to depression and can also impact the immune system, illustrating the interconnectedness of mental health and immune function. Hematopoietic stem cells (HSCs) can directly sense neuroendocrine signals in bone marrow and play a fundamental role in the maintenance of immune homeostasis. However, it is unclear how psychological stress impacts HSCs in depression. Here, we report that neuroendocrine factor arginine vasopressin (AVP) promotes myeloid-biased HSC differentiation by activating neutrophils. AVP administration increases neutrophil and Ly6C^hi monocyte production by triggering HSCs that rely on intrinsic S100A9 in mice. When stimulated with AVP, neutrophils return to the bone marrow and release interleukin 36G (IL-36G), which interacts with interleukin 1 receptor-like 2 (IL-1RL2) on HSCs to produce neutrophils with high Elane expression that infiltrate the brain and induce neuroinflammation. Together, these findings define HSCs as a relay between psychological stress and myelopoiesis and identify the IL-36G-IL-1RL2 axis as a potential target for depression therapy.

01 Jul 2024·Biochemical and Biophysical Research Communications

LEPR/FOS/JUNB signaling pathway contributes to chronic restraint stress-induced tumor proliferation

Article

Author: Zhu, Jian ; Liu, Qing ; Zhao, Linjing ; Mo, Fengfeng ; Huang, Yanan ; Nie, Shuang

BACKGROUND & AIMSPsychosocial stress has become an unavoidable part of life, which was reported to promote tumor development. Chronic stress significantly promotes the norepinephrine (NE) secretion and the expression of leptin receptor (LEPR), leading to tumor invasion, metastasis, and proliferation. However, the mechanism of chronic stress-induced tumor proliferation remains unclear.METHODSTo reveal the effect of chronic stress on tumor proliferation, subcutaneous tumor models combined with chronic restraint stress (CRS) were established. Combined with the transcript omics database of liver cancer patients, the target pathways were screened and further verified by in vitro experiments.RESULTSThe results showed that the CRS with subcutaneous tumor transplantation (CRS + tumor) group exhibited significantly larger tumor sizes than the subcutaneous tumor transplantation (tumor) group. Compared with the tumor group, CRS obviously increased the mRNA levels of LEPR, FOS, and JUNB of tumor tissues in the CRS + tumor group. Furthermore, the treatment with norepinephrine (NE) significantly elevated the survival rate of H22 cells and enhanced the expression of LEPR, FOS, and JUNB in vitro. Silencing LEPR significantly reduced the expression of FOS and JUNB, accompanied by a decrease in H22 cell viability.CONCLUSIONSOur study demonstrated that CRS activates the LEPR-FOS-JUNB signaling pathway by NE, aggravating tumor development. These findings might provide a scientific foundation for investigating the underlying pathological mechanisms of tumors in response to chronic stress.

07 Jun 2024·Open Medicine

Correlation between fat-soluble vitamin levels and inflammatory factors in paediatric community-acquired pneumonia: A prospective study

Article

Author: Liao, Jianyuan ; Chen, Gangxin ; Zhang, Lifang ; Luo, Yuxing

AbstractCommunity-acquired pneumonia (CAP) is a common respiratory disease in children. This prospective cohort study of 110 children with CAP and 100 healthy children investigated the relationship between the levels of vitamin A, D and E and inflammatory markers, such as tumour necrosis factor (TNF-a), interleukin-1 (IL-1), interleukin-10 (IL-10), neutrophils (NE) and C-reactive protein (CRP), in CAP. The haemoglobin, leukocyte concentration, NE, monocytes and CRP concentration in the CAP group showed significant differences (P < 0.05). The levels of vitamin A, D and E in the CAP group were lower than those in the control group, while the levels of TNF-a and IL-1 were higher than in the control group; the differences were statistically significant (P < 0.05). The IL-10 levels showed no significant differences (P > 0.05). Pearson analysis revealed that the vitamin A, D and E levels were all correlated with the TNF-a, IL-10 and CRP levels (P < 0.05). The vitamin A, D and E levels of the CAP children were lower than those of the healthy children. Thus, the content of fat-soluble vitamins is correlated with the secretion of TNF-a and IL-10. The research provides a new direction for the prevention, diagnosis and treatment of CAP.

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