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Last update 08 May 2025

GAT

Last update 08 May 2025

Basic Info

Synonyms

AAc, ACGNAT, Acyl-CoA:glycine N-acyltransferase

+ [10]

Introduction

Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.

Drugs associated with GAT

NNC-711

Target

GAT

Mechanism

GAT inhibitors

Active Org.

Novo Nordisk A/S

Originator Org.

Novo Nordisk A/S

Active Indication

Epilepsy

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

CI-966

Target

GAT

Mechanism

GAT inhibitors

Active Org.-

Originator Org.

Pfizer Inc.

Active Indication-

Inactive Indication

Epilepsy

Drug Highest PhaseDiscontinued

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with GAT

100 Translational Medicine associated with GAT

0 Patents (Medical) associated with GAT

1,237

Literatures (Medical) associated with GAT

31 Dec 2025·Renal Failure

Higher serum Metrnl levels are associated with increased vascular calcification in hemodialysis patients

Article

Author: Zhang, Aihua ; Ren, Wenwen ; Liu, Conghui

BACKGROUNDMeteorin-like (Metrnl) is a newly identified secreted protein that plays important roles in metabolic and inflammation-related diseases. Our study aimed to evaluate serum Metrnl levels and establish their relationship with vascular calcification (VC) in hemodialysis (HD) patients.METHODSIn total, 313 HD patients and 41 healthy individuals, as controls, were included. Serum levels of Metrnl and other clinical and laboratory parameters were compared. VC was evaluated based on the abdominal aortic calcification (AAC) scores. HD patients were divided into a high-AAC score group (AAC score ≥ 4) and a low-AAC score group (AAC score < 4).RESULTSHD patients had higher serum Metrnl levels than the controls (0.52 ± 0.26 ng/ml vs. 0.24 ± 0.11 ng/ml, p < 0.001). Serum Metrnl concentrations were significantly higher in HD patients in the high-AAC score group than in those in the low-AAC score group (0.55 ± 0.27 vs. 0.49 ± 0.24 ng/ml, p = 0.041). Multivariate logistic regression revealed that serum Metrnl, age, diabetes mellitus, serum total carbon dioxide (tCO₂) and serum intact parathyroid hormone (iPTH) were significant independent determinants of high AAC scores.CONCLUSIONThe results herein provide the first clinical evidence of the association between serum Metrnl and VC in HD patients. Higher Metrnl levels, older age, diabetes mellitus, and higher serum tCO₂ and iPTH levels are independent determining factors for high AAC scores in HD patients.

01 May 2025·Journal of Colloid and Interface Science

Boosting peroxymonosulfate activation for complete removal of gatifloxacin by a bead-chain zeolitic imidazolate framework composite

Article

Author: Yang, Xiupei ; Yang, Qiang ; Chen, Lianfang ; Zhang, Lilei ; Zhao, Yan ; Tang, Fenglin

A bead-chain metal-organic framework composite was designed and synthesized by assembling a zeolitic imidazolate framework (ZIF) onto manganese dioxide (MnO₂) nanowires. The prepared catalyst MnO₂@ZIF-X (X = 1, 2 and 3) was used to facilitate gatifloxacin (GAT) degradation by using potassium peroxymonopulfate (PMS) as an activator. MnO₂@ZIF-2 exhibited excellent catalytic performance, achieving 100 % degradation of GAT (10 mg/L) in the presence of PMS (1 mM) in 15 min, and the toxicity of the majority of degradation intermediates decreased. Furthermore, the removal efficiency was maintained above 90 % throughout a wide pH range (3-11) and in the coexistence of anions ( [Formula: see text] , Cl^-, SO₄^2-). The main mechanism of the MnO₂@ZIF-2/PMS system involves the synergistic effect of radicals and non-radicals (single linear oxygen and electron-mediated transfer), making the system highly resistant to interference from environmental matrices. Moreover, the GAT degradation pathway was elucidated through intermediate analysis and theoretical calculations. In particular, MnO₂@ZIF-2 was well dispersed on a microporous filter membrane to create an immobilized membrane reactor that displayed excellent catalytic performance for the continuous degradation of GAT for 300 min. This work offers an avenue for the design of catalysts with good catalytic activity, particularly for PMS activation in antibiotic wastewater remediation.

10 Apr 2025·Nature

Convergent vocal representations in parrot and human forebrain motor networks

Article

Author: Yang, Zetian ; Long, Michael A

Cortical networks for the production of spoken language in humans are organized by phonetic features^1,2, such as articulatory parameters^3,4 and vocal pitch^5,6. Previous research has failed to find an equivalent forebrain representation in other species^7-11. To investigate whether this functional organization is unique to humans, here we performed population recordings in the vocal production circuitry of the budgerigar (Melopsittacus undulatus), a small parrot that can generate flexible vocal output^12-15, including mimicked speech sounds¹⁶. Using high-density silicon probes¹⁷, we measured the song-related activity of a forebrain region, the central nucleus of the anterior arcopallium (AAC), which directly projects to brainstem phonatory motor neurons^18-20. We found that AAC neurons form a functional vocal motor map that reflects the spectral properties of ongoing vocalizations. We did not observe this organizing principle in the corresponding forebrain circuitry of the zebra finch, a songbird capable of more limited vocal learning²¹. We further demonstrated that the AAC represents the production of distinct vocal features (for example, harmonic structure and broadband energy). Furthermore, we discovered an orderly representation of vocal pitch at the population level, with single neurons systematically selective for different frequency values. Taken together, we have uncovered a functional representation in a vertebrate brain that displays unprecedented commonalities with speech-related motor cortices in humans. This work therefore establishes the parrot as an important animal model for investigating speech motor control and for developing therapeutic solutions for addressing a range of communication disorders^22,23.

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