This study will test the safety of a drug called SGN-ALPV in participants with solid tumors. It will also study the side effects of this drug. A side effect is anything a drug does to your body besides treating your disease.
Participants will have solid tumor cancer that has spread through the body (metastatic) or cannot be removed with surgery (unresectable).
This study will have three parts. Parts A and B of the study will find out how much SGN-ALPV should be given to participants. Part C will use the dose and schedule found in Parts A and B to find out how safe SGN-ALPV is and if it works to treat solid tumor cancers.

Start Date21 Apr 2022

Sponsor / Collaborator

Seagen, Inc.

100 Clinical Results associated with ALPP x ALPPL2

100 Translational Medicine associated with ALPP x ALPPL2

0 Patents (Medical) associated with ALPP x ALPPL2

Literatures (Medical) associated with ALPP x ALPPL2

01 Nov 2022·International Immunopharmacology

Amomum longiligulare polysaccharide 1- PLGA nanoparticle promotes the immune activities of T lymphocytes and dendritic cells

Article

Author: Wu, Haowen ; Ni, Jiahao ; Liu, Jiaguo ; Chen, Huricha ; Teng, Ling ; Chen, Yun ; Xing, Zengyang

Amomum longiligulare polysaccharide 1 (ALP1) was extracted from Amomum longiligulare T.L. Wu fruits and the poly (lactic-co-glycolic acid) nanoparticle enveloping ALP1 (ALPP) showed a good promoting effect on the activation of macrophages in our previous study. To further understand the immunomodulatory property of ALPP, the effect of ALPP on T lymphocytes and dendritic cells was investigated in the present study. The proliferation rates of chicken T lymphocytes and chicken bone marrow dendritic cells (chBM-DCs) that were treated with ALP1 or ALPP were determined by using MTT method. Meanwhile, the relative mRNA levels of cytokines from T lymphocytes and surface molecules of chBM-DCs were determined by using qRT-PCR method. In addition, the drug uptake capacity of chBM-DCs was also tested. As a result, the promoting effect on the proliferation of T lymphocytes and the Th1-type immune response of ALPP was better than that of ALP1. In addition, ALPP was much more effectively swallowed by chBM-DCs so that its promoting effect on the proliferation and maturation of chBM-DCs was higher than that of ALP1. To conclude, ALPP had a stronger immunomodulatory activity than ALP1, and showed the potential to become a new type of immune booster.

01 Oct 2021·International ImmunopharmacologyQ2 · MEDICINE

Preparation of Amomum longiligulare polysaccharides 1- PLGA nanoparticle and its immune enhancement ability on RAW264.7 cells

Q2 · MEDICINE

Article

Author: Zhu, Yongjian ; Zhou, Ruigang ; Zhang, Chenglong ; Chen, Yun ; Teng, Ling ; Yang, Yuhui

Amomum longiligulare polysaccharides 1 (ALP1) was a glucosan that possessed an immune enhancement ability. However, disadvantages including short biological half-life hindered the application of ALP1. To solve these shortcomings, ALP1 was successfully prepared to nanoparticles (ALPP) with poly (lactic-co-glycolic acid) in the present study. And the optimal preparation conditions were developed by using the response surface method with a Box-Behnken design. The results showed that the encapsulation efficiency of ALPP reached a high level (79.88%) when the volume ratio of the water phase to the organic phase was 1:7, the volume ratio of the primary emulsion to the external water phase was 1:7, and the concentration of F68 was 0.7%. ALPP showed a controlled and sustained release. Meanwhile, the scanning electron microscope results showed that ALPP was a kind of nanoparticles with a diameter of 389.77 nm. In addition, the activating effect of ALPP on macrophages was studied. The results indicated that ALPP showed a better activity on promoting the RAW264.7 cells' activities and polarizing RAW264.7 cells into both M1 type and M2 type macrophages, compared to ALP1.

01 Nov 2011·Journal of Cellular BiochemistryQ3 · BIOLOGY

A proline rich acidic protein PRAP identified from uterine luminal fluid of estrous mice is able to enhance the estrogen responsiveness of Ishikawa cells

Q3 · BIOLOGY

Article

Author: Chia-Jen Tseng ; Jyh-Bing Tang ; Yee-Hsiung Chen ; Tsai-Fu Hsieh

AbstractUsing mice as experimental animals, proteins in the uterine luminal fluid (ULF) from both adults and diethylstilbestrol dipropionate (DES)‐treated immature animals were resolved by 2D gel electrophoresis. Two of the protein spots, (a) and (b) around the positions of 18–20 kDa, in the adult ULF were not found in the DES‐treated ULF. Automated Edman degradation established the same N‐terminal sequences of AHQVPVKTKGKHVFP for the two protein spots. Two trypsin digests of spot (a) were analyzed using CID MS/MS to establish the peptide sequences DNQLGPLLPEPK and RPDAMTWVETEDILSHLR. These partial sequences were confirmed in the cDNA‐deduced mouse proline rich acidic protein (PRAP). Using human Ishikawa cell line as a surrogate endometrial model, we demonstrated rapid entrance of exogenous PRAP into the cells and its ability to enhance alkaline phosphatase activity of the E2‐stimulated cells. Further, the transcripts of five estrogen‐responsive genes, including ALPP (Placental alkaline phosphtase), ALPPL (placental alkaline phosphatase‐like 2), TGF (transforming growth factor), PR (progesterone receptor), and Wnt7a, were measured after the cell incubation in modified Eagle medium containing 0.1 nM E2, or 0–25 µM PRAP, or both together at 37°C for 48 h. As compared with the control, E2 alone increased the transcripts of ALPP, ALPPL, TGF‐α, and PR, and reduced the transcript of Wnt7a, whereas PRAP alone had a slight impact on their expression. E2 together with PRAP greatly increased the E2‐stimulated transcriptions of ALPP, ALPPL, TGF‐α, and PR, and markedly reduced the E2‐suppressed transcription of Wnt7a. J. Cell. Biochem. 112: 3122–3128, 2011. © 2011 Wiley Periodicals, Inc.

Analysis

Perform a panoramic analysis of this field.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis