Synonyms Cbl-interacting protein p70, KIAA1959, STS-1 + [9] |
Introduction Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination. |
Target |
Mechanism UBASH3B inhibitors |
Active Org. |
Originator Org. |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. JP |
First Approval Date28 Sep 1990 |
Start Date13 Mar 2024 |
Sponsor / Collaborator |
Start Date22 Jan 2024 |
Sponsor / Collaborator |
Start Date01 Jan 2024 |
Sponsor / Collaborator |