Last update 01 Nov 2024

UBASH3B

Basic Info

Synonyms
Cbl-interacting protein p70, KIAA1959, STS-1
+ [9]
Introduction
Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.

Analysis

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