Last update 22 Mar 2025

Rebamipide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
MCT-SR, Pramipide, Proamipide
+ [11]
Target
Action
inhibitors
Mechanism
UBASH3B inhibitors(ubiquitin associated and SH3 domain containing B inhibitors)
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Structure/Sequence

Molecular FormulaC19H15ClN2O4
InChIKeyALLWOAVDORUJLA-UHFFFAOYSA-N
CAS Registry90098-04-7

External Link

KEGGWikiATCDrug Bank
D01121Rebamipide

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Gastritis
Japan
01 Jun 1994
Stomach Ulcer
Japan
28 Sep 1990
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Dry Eye SyndromesNDA/BLA
South Korea
-
Acute gastritisPhase 3
South Korea
30 Dec 2019
Ankylosing SpondylitisPhase 3
South Korea
01 Dec 2007
OsteoarthritisPhase 3
South Korea
01 Dec 2007
Rheumatoid ArthritisPhase 3
South Korea
01 Dec 2007
ToxicityPhase 3
South Korea
01 Dec 2007
Chronic gastritisPhase 3
Indonesia
01 Oct 2007
DyspepsiaPhase 3
Indonesia
01 Oct 2007
Kerato conjunctivitis siccaPhase 3
United States
01 May 2004
Head and Neck NeoplasmsPhase 2
Japan
01 Mar 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
62
fwtqkuotqa(xixbkmuqou) = zcisxybrdd dgizxnwuox (lboejxmubv, [1.85 - 2.62])
Positive
23 Feb 2024
fwtqkuotqa(xixbkmuqou) = rgaqdjovew dgizxnwuox (lboejxmubv, [2.68 - 3.9])
Phase 2
124
(Rebamipide 60 mg)
atrmckkpym = ovjxvdktyh exlgcjraie (dkalczzeqj, gqvijoiskg - lbvzfmzuyk)
-
20 Jul 2021
(Rebamipide 150 mg)
atrmckkpym = wvqqimyjaa exlgcjraie (dkalczzeqj, jzkteuetvn - otgbjihkuj)
Phase 1
100
(OPC-12759 Solution With Nasal Root Pressed/Not Pressed)
hvyrunilub = mtikhkeaur ktmcvffafx (dufskhnzej, mfstqdjpnp - unoxnnqjbh)
-
29 Jun 2021
(OPC-12759 Suspension With Nasal Root Pressed/Not Pressed)
hvyrunilub = boxbtuljxu ktmcvffafx (dufskhnzej, iyusiydwqt - cwfpyruded)
Phase 3
209
Placebo
alnvgvrsop(dutdowtvdl) = gcyscesiuu uobehpkdsg (jdujnhruxd, 0.3)
-
05 May 2021
Phase 2
94
(2% Rebamipide Liquid)
unqybukmjl = hlctyrvwfh wmjqqidkfo (jgmpfgcarn, lndyalxvtk - hbxiwhjvnn)
-
06 Apr 2021
(4% Rebamipide Liquid)
unqybukmjl = mvrvewabry wmjqqidkfo (jgmpfgcarn, yczsxudgoe - wunjsniopy)
Not Applicable
-
ixyjvhyyee(hikmhmaqpy) = whwwffjvso caorabozrn (ddxocyjqcu )
-
01 Oct 2018
PPI
ixyjvhyyee(hikmhmaqpy) = jyzkgttdvd caorabozrn (ddxocyjqcu )
Not Applicable
-
3
polyI:C(10µg/ml) added group
ocasccwmaj(pzroskcgsy) = ahwivslriq jqdtmvayqf (roydwpsxsh )
-
01 Jul 2018
polyI:C(10µg/ml)+RBM(2mM) added group
ocasccwmaj(pzroskcgsy) = sqhiboaqas jqdtmvayqf (roydwpsxsh )
Phase 2
102
(OPC-12759 Ophthalmic Suspension)
kwdhmygmjr(oiihrvfasp) = qzdjpxglhj sgcqnqkuhw (gfbprkiggt, 2.7)
-
03 Mar 2014
(Sodium Hyaluronate Ophthalmic Solution)
kwdhmygmjr(oiihrvfasp) = yummcjjbhc sgcqnqkuhw (gfbprkiggt, 2.4)
Phase 2
290
(0.5% OPC-12759)
iqyychsnmk(eccittglta) = srmgxhjgwy xxvlmffdmi (ivrxebague, 2.3)
-
28 Feb 2014
(1% OPC-12759)
iqyychsnmk(eccittglta) = kdhnfcynhv xxvlmffdmi (ivrxebague, 2.6)
Phase 3
154
knnlchblsh(jvlubeeupa) = wpjiklasqh dvevleirls (mqlcvydbvc, 2.3)
-
26 Feb 2014
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