Last update 23 Jan 2025

IL-2R x CTLA4 x IL-2Rβγ x CD28

Basic Info

Related Targets
IL-2RCTLA4IL-2Rβγ[+1]

Related

1
Drugs associated with IL-2R x CTLA4 x IL-2Rβγ x CD28
SIM-323
Target
CD28 x CTLA4 x IL-2R x IL-2Rβγ
Mechanism
CD28 inhibitors [+3]
Active Org.
GI Innovation, Inc.GI Innovation, Inc.
Originator Org.
Simcere Pharmaceutical Group Ltd.Simcere Pharmaceutical Group Ltd. [+1]
Active Indication
Advanced Malignant Solid Neoplasm [+13]
Inactive Indication-
Drug Highest PhasePhase 1/2
First Approval Ctry. / Loc.-
First Approval Date20 Jan 1800
2
Clinical Trials associated with IL-2R x CTLA4 x IL-2Rβγ x CD28
KCT0009580
/ Not yet recruitingPhase 2IIT
Phase 2a, open-label, multi-center study of GI-101A or GI-102 (CD80-IgG4 FC-IL2v) in patients with relapsed/refractory diffuse large B-cell lymphoma following anti-CD19 chimeric antigen receptor T-cell therapy (CARNATION)
NCT04977453
/ RecruitingPhase 1/2
A Phase 1/2, Open-label, Dose-escalation, and Expansion Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Therapeutic Activity of GI-101 As a Single Agent and in Combination with Pembrolizumab, Lenvatinib or Local Radiotherapy in Patients with Advanced or Metastatic Solid Tumors (Keynote B59)
100 Clinical Results associated with IL-2R x CTLA4 x IL-2Rβγ x CD28
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100 Translational Medicine associated with IL-2R x CTLA4 x IL-2Rβγ x CD28
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0 Patents (Medical) associated with IL-2R x CTLA4 x IL-2Rβγ x CD28
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