Last update 01 Nov 2024

SARS-CoV 3CLpro

Last update 01 Nov 2024

Basic Info

Synonyms

SARS-CoV nsp5

Introduction-

Drugs associated with SARS-CoV 3CLpro

HP-211206

Target

SARS-CoV 3CLpro

Mechanism

SARS-CoV 3CLpro inhibitors

Active Org.

The Chinese University of Hong Kong

Originator Org.

The Chinese University of Hong Kong

Active Indication

COVID-19

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

SARS-CoV Nsp3 inhibitor

Target

SARS-CoV 3CLpro

Mechanism

SARS-CoV 3CLpro inhibitors

Active Org.

The University of California, San Francisco

Originator Org.

The University of California, San Francisco

Active Indication

COVID-19

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

3CLpro inhibitors(Shanghai Ark Biopharmaceutical )

Target

SARS-CoV 3CLpro

Mechanism

SARS-CoV 3CLpro inhibitors

Active Org.

Shanghai Ark Biopharmaceutical Co., Ltd.Startup

Originator Org.

Shanghai Ark Biopharmaceutical Co., Ltd.Startup

Active Indication

COVID-19

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with SARS-CoV 3CLpro

100 Translational Medicine associated with SARS-CoV 3CLpro

0 Patents (Medical) associated with SARS-CoV 3CLpro

Literatures (Medical) associated with SARS-CoV 3CLpro

01 Dec 2022·Natural Products and BioprospectingQ4 · CHEMISTRY

Citrus fruits are rich in flavonoids for immunoregulation and potential targeting ACE2

Q4 · CHEMISTRY

Article

Author: Bao, Shuzheng ; Xu, Qiang ; Li, Ming ; Ma, Zhaocheng ; Cheng, Liping ; Liu, Wenting ; Huang, Jie ; Zheng, Weikang

AbstractThe most recent outbreak of 2019 novel coronavirus, named as COVID-19, caused pneumonia epidemic in Wuhan with 2121 deaths cases as of February 20th 2020. Identification of effective antiviral agents to combat the novel coronavirus is urgently needed. Citrus fruit peel or wild citrus are rich in flavonoids, and clinically documented for roles in relief of cough and promotion of digestive health. Therefore, citrus fruits are assumed to possess antivirus activities or enhance the host immunity. A previous study found that hesperetin could act as a high potent inhibitor of SARS-CoV 3CLpro. We determined six flavonoid compounds’ content in three citrus species by using LC–MS technique. The content of naringin and naringenin was at higher levels in pummelo. Hesperetin and hesperidin were highly accumulated in mandarin and sweet orange. The subsequent in vitro and in vivo experiments indicated that naringin could inhibit the expression of the proinflammatory cytokines (COX-2, iNOS, IL-1β and IL-6) induced by LPS in Raw macrophage cell line, and may restrain cytokine through inhibiting HMGB1 expression in a mouse model. The results revealed that naringin may have a potential application for preventing cytokine storm. We simulated molecular docking to predict the binding affinity of those flavonoids to bind Angiotensin-converting enzyme 2 (ACE 2), which is a receptor of the coronavirus. Consideration of the potential anti-coronavirus and anti-inflammatory activity of flavonoids, the citrus fruit or its derived phytochemicals are promising in the use of prevention and treatment of SARS-CoV-2 infection.Graphical Abstract

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SARS-CoV 3CLpro

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