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Last update 08 May 2025

GGCT

Last update 08 May 2025

Basic Info

Synonyms

C7orf24, chromosome 7 open reading frame 24, CRF21

+ [6]

Introduction

Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis (PubMed:18515354). Induces release of cytochrome c from mitochondria with resultant induction of apoptosis (PubMed:16765912).

Drugs associated with GGCT

MAM-LISA-103

Target

GGCT

Mechanism

GGCT modulators [+1]

Active Org.

Kanagawa University

Originator Org.

Kanagawa University

Active Indication

Neoplasms

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with GGCT

100 Translational Medicine associated with GGCT

0 Patents (Medical) associated with GGCT

267

Literatures (Medical) associated with GGCT

01 Apr 2025·Advanced Science

Host Plasma Microenvironment in Immunometabolically Impaired HIV Infection Leads to Dysregulated Monocyte Function and Synaptic Transmission Ex Vivo

Article

Author: Sood, Vikas ; Mardinoglu, Adil ; Rucevic, Marijana ; Nielsen, Susanne D. ; Pawar, Vinay ; Gupta, Soham ; Végvári, Ákos ; Syed, Yasir Ahmed ; Akusjärvi, Sara Svensson ; O'Mahony, Liam ; Escós, Alejandra ; Gelpi, Marco ; Hov, Johannes R. ; Naval, Prajakta ; Lourda, Magda ; Trøseid, Marius ; Björkström, Niklas K. ; Benfield, Thomas ; Savai, Rajkumar ; Vestad, Beate ; Nikouyan, Negin ; Olofsson, Anna ; Neogi, Ujjwal ; Wang, Tianqi ; Knudsen, Andreas D. ; Weiss, Siegfried ; Karlsson, Annika C. ; Schuster, Sabrina ; Varshney, Mukesh Kumar ; Mikaeloff, Flora ; Benfeitas, Rui ; de Magalhães, João Pedro ; Høgh, Julie

AbstractRisk stratification using multi‐omics data deepens understanding of immunometabolism in successfully treated people with HIV (PWH) is inadequately explained. A personalized medicine approach integrating blood cell transcriptomics, plasma proteomics, and metabolomics is employed to identify the mechanisms of immunometabolic complications in prolonged treated PWH from the COCOMO cohort. Among the PWHs, 44% of PWH are at risk of experiencing immunometabolic complications identified using the network‐based patient stratification method. Utilizing advanced machine learning techniques and a Bayesian classifier, five plasma protein biomarkers; Tubulin Folding Cofactor B (TBCB), Gamma‐Glutamylcyclotransferase (GGCT), Taxilin Alpha (TXLNA), Pyridoxal Phosphate Binding Protein (PLPBP) and Large Tumor Suppressor Kinase 1 (LATS1) are identified as highly differentially abundant between healthy control (HC)‐like and immunometabolically at‐risk PWHs (all FDR<10−10). The personalized metabolic models predict metabolic perturbations, revealing disruptions in central carbon metabolic fluxes and host tryptophan metabolism in at‐risk phenotype. Functional assays in primary cells and cortical forebrain organoids (FBOs) further validate this. Metabolic perturbations lead to persistent monocyte activation, thereby impairing their functions ex vivo. Furthermore, the chronic inflammatory plasma microenvironment contributes to synaptic dysregulation in FBOs. The endogenous plasma inflammatory microenvironment is responsible for chronic inflammation in treated immunometabolically complicated at‐risk PWH who have a higher risk of cardiovascular and neuropsychiatric disorders.

01 Mar 2025·Theriogenology

Supplementation with N-Acetyl-L-cysteine during in vitro maturation improves goat oocyte developmental competence by regulating oxidative stress

Article

Author: Ji, Quan ; Cao, Maosheng ; Li, Ruiyang ; Wang, Xiaodong ; Ju, Yonghong ; Wang, Yanfei ; Zhao, Jiafu ; Ruan, Yong ; Wang, Qingwei ; Chen, Xiang ; An, Pengcheng

Oocyte quality can affect mammal fertilization rate, early embryonic development, pregnancy maintenance, and fetal development. Oxidative stress induced by reactive oxygen species (ROS) is one of the most important causes of poor oocyte maturation in vitro. To reduce the degree of cellular damage caused by ROS, supplementation with the antioxidant N-Acetyl-L-cysteine (NAC) serves as an effective pathway to alleviate glutathione (GSH) depletion during oxidative stress. This study investigated the effects of NAC supplementation during in vitro maturation of goat oocytes and explored the molecular mechanisms of maturation by transcriptome sequencing of MⅡ oocytes. The results showed that 1.5 mM NAC significantly increased the rates of oocyte maturation and cumulus cell expansion and improved the subsequent development of embryos. During the subsequent culture of parthenogenetically activated embryos, 1.5 mM NAC significantly increased the division rate of oocytes and blastocyst rate. It also reduced the accumulation of ROS, increased the level of GSH, alleviated oxidative stress, and enhanced the antioxidant capacity and cell metabolic activity. Transcriptome sequencing results revealed that NAC treatment significantly increased the expression of SIRT1, GGCT, and MITF genes related to the cellular antioxidant system, as well as the IDH3G gene related to energy metabolism, and decreased the expression of CASP8, FOS, and MMP1 genes related to apoptosis and cell invasion, as well as the CCL2. and CXCL8 genes related to the inflammatory response. In conclusion, the findings suggest that NAC supplementation significantly reduces oxidative stress, improves antioxidant capacity and metabolic activity, promotes oocyte maturation, and improves oocyte quality.

28 Feb 2025·ACS Sensors

Application of Intramolecular O-to-N Phosphoryl Transfer Reaction to Design Fluorogenic Probes to Detect Activities of Enzymes That Metabolize Short Peptides and Acylamino Acids

Article

Author: Okabe, Takayoshi ; Minoda, Mayano ; Kato, Kazuki ; Kojima, Hirotatsu ; Nishimasu, Hiroshi ; Isayama, Yukari ; Komatsu, Toru ; Urano, Yasuteru ; Sawayama, Risako

We propose the design strategy of fluorogenic probes of proteases/peptidases and acylamino acid hydrolases utilizing an intramolecular O-to-N phosphoryl transfer reaction, in which the main chain of peptides or amino acids is retained from the natural substrate but the side chain was designed to attach the fluorophore. The strategy is useful to design fluorogenic probes for peptidases/proteases that do not prefer the main chain modification and acylamino acid hydrolases. We have developed the fluorogenic substrates for GGT5, GGCT, and PM20D1 and have performed the screening of PM20D1 inhibitors/activators to characterize the compounds that modify the activity of PM20D1.

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GGCT

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