Last update 01 Nov 2024

miR-210

Last update 01 Nov 2024

Basic Info

Synonyms

hsa-mir-210, microRNA 210, MIR210

+ [1]

Introduction-

Drugs associated with miR-210

Targapremir-210

Target

miR-210

Mechanism

miR-210 inhibitors

Active Org.

Janssen Research & Development LLC

Originator Org.

The Scripps Research Institute

Active Indication

Non-Muscle Invasive Bladder Neoplasms

Inactive Indication

Breast Cancer

Drug Highest PhaseIND Approval

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with miR-210

100 Translational Medicine associated with miR-210

0 Patents (Medical) associated with miR-210

1,558

Literatures (Medical) associated with miR-210

01 Feb 2025·Non-coding RNA Research

MiRNA expression affects survival in patients with obstructive sleep apnea and metastatic colorectal cancer

Article

Author: Moriondo, Giorgia ; Sabato, Roberto ; Lacedonia, Donato ; Giordano, Guido ; Bruno, Giuseppina ; Landriscina, Matteo ; Foschino Barbaro, Maria Pia ; Soccio, Piera ; Tondo, Pasquale ; Scioscia, Giulia

IntroductionThe relationship between obstructive sleep apnea (OSA) and cancer has been recognized for some time now. However, little is known about the mechanisms by which sleep apnea promotes tumorigenesis and the impact of OSA on survival after cancer diagnosis. In the last few years, research has focused on the exploration of different biomarkers to understand the mechanisms underlying this relationship and miRNAs, non-coding single strands of about 22 nucleotides that post-transcriptionally regulate gene expression, have emerged as possible actors of this process.The aim of the study was to evaluate the impact of OSA on survival of metastatic colorectal cancer (mCRC) patients based on the expression of specific miRNAs.MethodsThe expression of 6 miRNAs, respectively miR-21, miR-23b, miR-26a, miR-27b, miR-145 and miR-210, was analyzed by qRT-PCR in patients' sera. Response to first-line therapy, Kaplan-Meier curves of overall and progression-free survival were used to evaluate survival in mCRC patients with and without OSA stratified for the expression of miRNAs.ResultsThe expression of miR-21, miR-23b, miR-26a and miR-210 was significantly upregulated in mCRCs with OSA compared to no OSA. In mCRC patients with OSA and increasing expression of miR-21, miR-23b, miR-26a and miR-210 risk of progression after first-line therapy was higher and both overall and progression-free survival were significantly worst. Conversely, as miR-27b and miR-145 expression increased, the life expectancy of patients diagnosed with OSA and mCRC improved markedly.ConclusionsThis study highlights the relevance of specific miRNAs on OSA in mCRCs and their significance as non-invasive biomarkers in predicting the prognosis in patients with mCRC and OSA.

01 Dec 2024·Molecular Biology Reports

Impacts of non-coding RNAs in the pathogenesis of varicocele

Review

Author: Ghafouri-Fard, Soudeh ; Fathi, Mohadeseh

Two classes of non-coding RNAs, namely lncRNAs and miRNAs have been reported to be involved in the pathogenesis of varicocele. MIR210HG, MLLT4-AS1, gadd7, and SLC7A11-AS1 are among lncRNAs whose expression has been changed in patients with varicocele in association with the sperm quality. Animal studies have also suggested contribution of NONRATG001060, NONRATG002949, NONRATG013271, NONRATG027523 and NONRATG023747 lncRNAs in this pathology. Meanwhile, expression of some miRNAs, such as miR-210-3p, miR-21, miR-34a, miR-122a, miR-181a, miR-34c and miR-192a has been altered in this condition. Some of these transcripts have the potential to predict the sperm quality. We summarize the impacts of lncRNAs and miRNAs in the pathogenesis of varicocele.

01 Dec 2024·Molecular Biology Reports

Liquid biopsy for CNS lymphoma: CSF exosomes and CSF exosomal miR-15a, miR-21, miR-155, miR-210, and miR-19b are promising biomarkers for diagnosis

Article

Author: Akdur, Kerime ; Oztanir, Mustafa Namik ; Elbasan, Elif Burce ; Cetin, Guven ; Seyithanoglu, Mehmet Hakan ; Hatiboglu, Mustafa Aziz ; Khan, Imran ; Karacam, Busra ; Mahfooz, Sadaf ; Papaker, Meliha Gundag

BACKGROUNDCentral nervous system lymphoma (CNSL) is a devastating disease with a poor prognosis. Early diagnosis, monitoring of the treatment response, and outcome prediction carry the utmost importance in the management of patients with CNSL. Surgical biopsy is the gold standard for tissue diagnosis, however, this procedure has potential complications. Therefore, there is a need for a method that provides information about diagnosis and patient monitoring to avoid surgical risks. The study aimed to investigate potential diagnostic biomarkers for patients with CNSL.METHODS AND RESULTSPatients with secondary CNSL were included in this study. Serum and cerebrospinal fluid (CSF) samples were collected before treatment and after completion of the treatment. Cell-free DNA (cfDNA), exosomes, free and exosomal microRNA (miR)-15a, miR-21, miR-155, miR-210, and miR-19b in both serum and CSF were examined, and they were compared with the controls. Also, their levels before and after treatment were compared. Nine patients with the diagnosis of secondary CNSL were reviewed. cfDNA, miR-15a, and miR-155 in serum, and exosome in CSF were found to be significantly higher in CNSL patients compared to the controls. Exosomal miR-15a, miR-21, miR-155, miR-210, and miR-19b in CSF were found to be significantly higher in CNSL patients compared to controls, whereas their levels in serum were not significantly high.CONCLUSIONSOur findings suggested that exosomes and exosomal miR-15a, miR-21, miR-155, miR-210 and miR-19b in CSF would be promising biomarkers for the diagnosis of patients with CNSL. Further studies are needed to confirm our findings.

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