Ang2 x VEGFR x Tie-2

SHANGHAI, July 26, 2024 /PRNewswire/ -- On July 15, Eluminex Biosciences announced that their tri-specific fusion antibody drug, EB-105, has administered its first dose to a diabetic macular edema patient in the United States. This clinical trial, known as LOTUS, is an open-label, multicenter, single-dose, dose-escalation clinical trial via intravitreal injection, currently being conducted in four hospitals across the United States. On July 22, 2024, Foreseen Biotechnology announced the exclusive global licensing of their ADC targeted drug, FS001, to Ipsen Pharma SAS of France. Ipsen will have exclusive rights to develop, manufacture, and commercialize FS001 worldwide. The total licensing fee, including upfront payments, milestone payments, and sales royalties, amounts to US$1.03 billion. Eluminex Biosciences's preclinical studies have shown that EB-105 can effectively inhibit signal transduction pathways such as VEGF-A/VEGFR-2, Ang-2/Tie-2, and IL-6/IL-6R. In addition to targeting vascular endothelial growth factor (VEGF) and angiopoietin-2 (Ang-2), EB-105 also inhibits intracellular inflammation-related signal transduction pathways, potentially offering better therapeutic effects for patients with diabetic retinopathy compared to current therapies. Foreseen Biotechnology's ADC targeted drug, FS001, is based on a novel tumor-associated antigen discovered by Foreseen Biotechnology. It has excellent targeting activity and high specificity. FS001 uses an innovative, stable, cleavable linker, coupled with a highly effective topoisomerase I inhibitor, demonstrating promising preclinical efficacy in various drug-resistant cancer models. Sanyou Bio assisted Eluminex Biosciences and Foreseen Biotechnology in the crucial work of discovering the above innovative drugs. Dr. Guojun Lang, CEO of Sanyou Bio, remarked: "Sanyou Bio is honored to have supported Eluminex Biosciences and Foreseen Biotechnology in their discovery of innovative biologic drugs! We wish for the continued success of these projects in the subsequent R&D, and hope they achieve clinical success soon to benefit patients worldwide!" About Eluminex Biosciences Eluminex was founded in early 2020. The company headquarters, research and development (R&D) center, and Good Manufacturing Practices (GMP) manufacturing facilities are located in Suzhou Industrial Park BioBAY, China, and the US regional office is located in Mountain View, California. Eluminex is currently supported by leading venture groups including Lilly Asia Ventures, Quan Capital, Hillhouse Ventures, and Cenova Capital and has raised over $100M (USD) through Series B+ financing. About Foreseen Biotechnology We are an emerging biotechnology company that pioneered a high throughput integrated translational proteomics platform powered by AI-based data analytical system to accelerate discovery of novel targets for therapeutics and diagnostics that are clinically relevant. We are building a pipeline of novel product candidates for the diagnosis and treatment of cancer, inflammatory/autoimmune diseases and neurological disorders. Foreseen Biotechnology is incubated by Nest.Bio Ventures. About Sanyou Bio Sanyou Biopharmaceuticals Co., Ltd. is a world-leading high-tech biotechnology enterprise focusing on R&D and services of innovative biologic drugs. Sanyou has built the 4C business patterns that integrate "differentiated CRO, integrated CDO, innovative CPO and characteristic CRS", to accomplish the mission "to make the R&D easy for innovative biologics". Sanyou has established an integrated innovative biologic drug R&D laboratory with advanced facilities, and has a professional team with the majority holding a Ph.D. or master degree. Sanyou has built three industry-leading innovative technology platforms featured by "super-trillion, integration, and intelligence" , which are comprised of more than 50 sub-platforms with the core innovative super-trillion phage display platform, and supported by platforms of material preparation, biologics discovery, molecule optimization, in vitro and in vivo efficacy, production cell line construction, upstream and downstream process development, preclinical R&D, industrialization development, etc. Sanyou's business network has expanded to all parts of the world, including Asia, US and Europe, and established branches in Boston, Philadelphia, San Diego and London. Sanyou has established friendly business relationships with more than 1000 pharmaceutical companies, drug R&D institutions and diagnostics companies worldwide. Sanyou received National-level certification as a high-tech enterprise and a Specialized and Sophisticated enterprise, and passed the ISO9001 quality assurance certification and GB/T intellectual property management system certification. SOURCE Sanyou Bio

EB-105 is the world's first pentavalent trispecific antibody targeting VEGF-A, VEGF-B, PlGF, Ang-2 and IL-6R in DME LOTUS study is the initial clinical trial of Eluminex's EB-105 being conducted in the United States SAN FRANCISCO and SUZHOU, China, July 15, 2024 /PRNewswire/ -- Eluminex Biosciences (Eluminex), a clinical stage, privately held biotechnology company focused on the development of advanced protein therapeutics for vision-threatening diseases announced the first dosing of EB-105 in patients with DME. The LOTUS trial is a first-in-human, open-label, multicenter, single injection, dose-escalation study of EB-105, Eluminex's lead ophthalmology asset being conducted at four sites in the United States. EB-105 has been shown in preclinical studies to potently inhibit VEGF-A/VEGFR-2, Ang-2/Tie-2, and IL-6/IL-6R signaling. Vitreous levels of IL-6, an inflammatory cytokine known to play a role in endothelial cell barrier dysfunction leading to vascular leakage, are elevated in patients with retinal disease including DME, diabetic retinopathy, neovascular (wet) age-related macular degeneration, and retinal vein occlusion. Dr. Ashkan Abbey, MD, Director of Clinical Research at Texas Retina Associates was the first retinal surgeon in the world to administer EB-105 treatment in the clinic. "Retina specialists welcome the addition of IL-6 pathway inhibition. We are in need of newer agents for these often difficult to manage patients. It is our hope that EB-105 will translate into incremental improvements in visual acuity, durability of response, and improved drying of the retina," he commented. "EB-105 represents a significant advance in the rapidly emerging science of polyvalent protein engineering," stated Charles Semba, MD, Eluminex's Chief Medical Officer. "For patients, it offers the promise of broader coverage of known biologic pathways associated with diabetic retinopathy and potentially better outcomes beyond currently available therapies," he added. About the LOTUS Trial LOTUS is a multicenter, single intravitreal (IVT) injection dose escalation study that will evaluate three dose levels of EB-105 in patients with center-involved diabetic macular edema and will enroll approximately 12 patients (4 per dose level). The primary objectives are safety, tolerability and pharmacodynamics (as assessed by imaging and visual acuity assessments) and to select the two best doses for a separate repeat injection study that is anticipated in 2025. Topline data from the current single injection study is anticipated in 1H 2025. In addition to Dr. Abbey are the following leading retinal surgeon investigators: Carl Awh, MD, Tennessee Retina, Nashville, TN; Veeral Sheth, MD, University Retina, Lemont, IL, and Charles Wyckoff, MD, Retina Consultants of Houston, Houston, TX. The study is being facilitated by the clinical research organization (CRO) Vial, Inc., based in San Francisco, CA. About Eluminex Biosciences Eluminex was founded in early 2020. The company headquarters, research and development (R&D) center, and Good Manufacturing Practices (GMP) manufacturing facilities are located in Suzhou Industrial Park BioBAY, China, and the US regional office is located in Mountain View, California. Eluminex is currently supported by leading venture groups including Lilly Asia Ventures, Quan Capital, Hillhouse BioVenture, Cenova Capital, and 3E BioVentures and has raised over $100M (USD) through Series B+ financing. For more information: . SOURCE Eluminex Biosciences