The pharmaceutical industry is experiencing a surge in the development of drugs aimed at treating
obesity, with a particular focus on creating an oral
GLP-1 option.
Eli Lilly and
Novo Nordisk are leading the charge, with their injectable GLP-1 drugs gaining popularity for weight loss. However, the real race is on for a pill form of these drugs, which could unlock a market potentially worth over $100 billion.
Eli Lilly is currently in Phase III trials with its small molecule drug,
orforglipron, showing promising weight loss results comparable to its injectable counterpart,
Zepbound. The company is already increasing production in anticipation of the drug's success. Meanwhile, Novo Nordisk has reported positive Phase I trial results for its next-generation co-agonist,
amycretin, which resulted in significant weight loss for patients.
Roche has entered the obesity treatment market through the acquisition of
Carmot Therapeutics, gaining access to two dual agonists and an oral GLP-1 drug in Phase I trials.
Pfizer is also working on an oral formulation of its
GLP-1 receptor agonist,
danuglipron, which is currently undergoing Phase I trials.
Smaller biotech companies like
Viking Therapeutics and
Structure Therapeutics are also making strides in this field. Viking has shown promising Phase I data for its dual GLP-1/
GIP receptor agonist, while Structure Therapeutics has demonstrated the potential of its oral small molecule GLP-1 asset in a Phase II trial.
The current injectable GLP-1 drugs face challenges such as cost, limited insurance coverage, and accessibility issues. The hope is that the introduction of oral drugs will address these concerns, driving down costs through competition and potentially leading to better insurance coverage.
Furthermore, the manufacturing process for injectable peptides is complex, often leading to drug shortages. The simplicity of producing oral medications is expected to ease this bottleneck, allowing for a more consistent supply and the flexibility for patients to switch brands in the event of supply chain issues.
The global focus on obesity treatment presents a significant opportunity for both large and small companies in the pharmaceutical industry. As these oral GLP-1 drugs progress through trials and potentially reach the market, they could significantly impact the accessibility and affordability of obesity treatments for a wider population.
How to obtain the latest research advancements in the field of biopharmaceuticals?
In the Synapse database, you can keep abreast of the latest research and development advances in drugs, targets, indications, organizations, etc., anywhere and anytime, on a daily or weekly basis. Click on the image below to embark on a brand new journey of drug discovery!
