Accessing Fluconazole Information on Synapse: A Step-by-Step Approach

Fluconazole is a small molecule drug used to treat various fungal infections. It is sold under the trade names Diflucan, Zoltec, and Loitin. Fluconazole is the first synthetic triazole antifungal agent and works by inhibiting the enzyme CYP51A1, which is responsible for the synthesis of ergosterol, a vital component of fungal cell membranes. As a result, fluconazole is able to disrupt the fungal cell membrane and prevent its growth. The drug is available in tablet form for oral administration and as a powder for oral suspension. Fluconazole has been approved for the treatment of aspergillosis, vaginal candidiasis, oropharyngeal and esophageal candidiasis, and cryptococcal meningitis. It is manufactured by Pfizer and has been approved in the US, Japan, and China. Fluconazole is a white crystalline solid that is slightly soluble in water and saline. Click on the image below to begin the exploration journey of Fluconazole through the Synapse database!

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