Bio Sequence

Biological Glossary | What is Open Reading Frame (ORF)?

23 November 2023
2 min read

Open reading frame (ORF), in the context of genomics, refers to a section of a DNA sequence that lacks a stop codon and potentially codes for a protein. A codon, which is a sequence of three nucleotides, is the basic unit of genomic information that represents a specific amino acid or signals the termination of protein synthesis. An ORF, usually found in a prokaryotic DNA sequence, spans from the start to stop codons and is bounded by stop codons.

In eukaryotic genes with multiple exons, an ORF only applies to spliced mRNAs, not genomic DNA, due to the presence of introns which can contain stop codons and/or cause shifts between reading frames. Another definition of ORF, useful in transcriptomics and metagenomics, defines it as a sequence that is divisible by three and is bounded by stop codons. In this context, an ORF represents parts of a gene rather than the entire gene.

Free registration is available for the Bio biological sequence database: https://bio.patsnap.com. Act now to expedite your sequence search tasks.

图片包含 图示

描述已自动生成

JAMP Pharma and Alvotech have been approved to sell Jamteki (AVT04), the first biosimilar of Stelara® (ustekinumab)
Latest Hotspot
3 min read
JAMP Pharma and Alvotech have been approved to sell Jamteki (AVT04), the first biosimilar of Stelara® (ustekinumab)
23 November 2023
Alvotech, a global biotech firm specializing in biosimilar drugs, and Canada's JAMP Pharma have announced Health Canada's approval for AVT04, a Stelara® biosimilar. It will be marketed as Jamteki™.
Read →
An analysis of ENB-003's R&D progress and its clinical results presented at the 2023 SITC
An analysis of ENB-003's R&D progress and its clinical results presented at the 2023 SITC
23 November 2023
The 2023 SITC Congress kicked off with a groundbreaking report on the latest clinical results of ENB-003, establishing a solid foundation for future research.
Read →
How To Obtain Target-Related Sequences Directly Through Target Name And Perform Sequence Alignment?
Bio Sequence
2 min read
How To Obtain Target-Related Sequences Directly Through Target Name And Perform Sequence Alignment?
23 November 2023
This article aims to instruct you on how to swiftly locate related sequences via a simple one-click method, using the target name.
Read →
Kyverna Therapeutics announces Phase 2 trial approval for KYV-101, a full human CD19 CAR T-Cell therapy for Myasthenia Gravis, by the FDA
Latest Hotspot
3 min read
Kyverna Therapeutics announces Phase 2 trial approval for KYV-101, a full human CD19 CAR T-Cell therapy for Myasthenia Gravis, by the FDA
22 November 2023
Kyverna Therapeutics reveals FDA approval for Phase 2 study of KYV-101, a complete human CD19 CAR T-Cell treatment for Myasthenia Gravis.
Read →
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.