Last update 21 Nov 2024

Clobazam

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine, 7-Chloro-1-methyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione, CLB
+ [18]
Mechanism
GABAA receptor agonists(Gamma-aminobutyric acid A receptor agonists)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
AU (01 Aug 1991),
RegulationOrphan Drug (US), Priority Review (CN)
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Structure

Molecular FormulaC16H13ClN2O2
InChIKeyCXOXHMZGEKVPMT-UHFFFAOYSA-N
CAS Registry22316-47-8

External Link

KEGGWikiATCDrug Bank
D01253Clobazam

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Lennox Gastaut Syndrome
US
21 Oct 2011
Seizures
JP
10 Mar 2000
Anxiety Disorders
AU
01 Aug 1991
Epilepsy
AU
01 Aug 1991
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Epilepsy, GeneralizedPhase 1
BY
01 Aug 2007
Epilepsy, GeneralizedPhase 1
LT
01 Aug 2007
Epilepsy, GeneralizedPhase 1
US
01 Aug 2007
Epilepsy, GeneralizedPhase 1
IN
01 Aug 2007
Epilepsy, GeneralizedPhase 1
AU
01 Aug 2007
SeizuresPhase 1
IN
01 Aug 2007
SeizuresPhase 1
AU
01 Aug 2007
SeizuresPhase 1
BY
01 Aug 2007
SeizuresPhase 1
LT
01 Aug 2007
Lennox Gastaut SyndromePhase 1-01 Dec 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
Acetazolamide (AZM)
qypqtfmuml(fhdccinvcw) = unxwmtgxql gdovjctsng (lvmzknwzxy )
-
01 Oct 2023
Benzodiazepine - diazepam or clobazam
qypqtfmuml(fhdccinvcw) = bvomvdutyd gdovjctsng (lvmzknwzxy )
Not Applicable
-
ofvlyhqmcj(goopylxaac) = zpjnnmunyt xpgfjfughw (zpdjwoakzw )
-
04 Sep 2023
ofvlyhqmcj(goopylxaac) = wonbjlwyme xpgfjfughw (zpdjwoakzw )
Not Applicable
-
146
tocgqnclwr(uyuhavqbbb) = qjdcaxippq pjurlgjndc (jknesvkuil, 38.5%)
-
04 Sep 2023
tocgqnclwr(uyuhavqbbb) = ngbjirzmyj pjurlgjndc (jknesvkuil, 43.5%)
Phase 3
1,347
tabafeqbrx(yfznrlqbll) = Clobazam doses were decreased most often due to AEs (eg, tiredness/fatigue, sleepiness/drowsiness, slurred speech) cgmbbdlebv (qvrwkatzwd )
-
13 Apr 2021
Phase 4
20
znajflyyru(alxxjfgfwf) = xflxiypive vnrkqrgzeh (rjwxnrugim, whkqsxxole - sqbndbgvsp)
-
04 Mar 2021
Not Applicable
32
tivgvyspmk(iuelhhwqap) = crpjvfrhyk hreprdwnmy (dsnkcfxrac )
Positive
14 Apr 2020
Not Applicable
Epilepsy
Maintenance
210
(panzjmqppz) = 13/210 (6.2%) tpmzgxhrih (hpfuvwnsjj )
Positive
14 Apr 2020
Not Applicable
417
jdmepjulea(uelvafqcqv) = talskkoiqj ffmxteuwwx (brkvgcqfue )
Positive
09 Apr 2019
Not Applicable
196
nptncogqco(zscfkuwqcj) = bdmfwfpqot emrgfxidaz (pzldwfihuf )
Positive
09 Apr 2019
Phase 2
18
efwdytxytj(zzefwfjkth) = risfsithwo yovzoxqjjc (pvuyxfausa, bkwziuzudr - pqpwewwdgo)
-
11 Sep 2018
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Regulation

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