Last update 01 Nov 2024

Maxillary Sinusitis

Last update 01 Nov 2024

Basic Info

Synonyms

MAXILLARY SINUSITIS, Maxillary Sinusitides, Maxillary Sinusitis

+ [17]

Introduction

Inflammation of the NASAL MUCOSA in the MAXILLARY SINUS. In many cases, it is caused by an infection of the bacteria HAEMOPHILUS INFLUENZAE; STREPTOCOCCUS PNEUMONIAE; or STAPHYLOCOCCUS AUREUS.

Drugs associated with Maxillary Sinusitis

Levofloxacin

Target

Bacterial Top II

Mechanism

Bacterial Top II inhibitors

Active Org.

CHIESI Farmaceutici SpA [+5]

Originator Org.

Johnson & Johnson

Active Indication

Otitis Externa [+31]

Inactive Indication

Abscess [+36]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date20 Dec 1996

Cefdinir

Target

PBPs

Mechanism

PBPs inhibitors [+1]

Active Org.

LTL Pharma Co., Ltd. [+5]

Originator Org.

Astellas Pharma, Inc.

Active Indication

Bronchitis [+10]

Inactive Indication

Acute Bronchitis [+26]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.-

First Approval Date01 Jan 1991

Clarithromycin

Target

50S subunit

Mechanism

50S subunit inhibitors

Active Org.

Xi'an Lijun Pharmaceutical Co., Ltd. [+3]

Originator Org.

Taisho Pharmaceutical Holdings Co., Ltd.

Active Indication

Mycobacterium Avium-Intracellulare Infection [+35]

Inactive Indication

Acquired Immunodeficiency Syndrome [+10]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.-

First Approval Date17 Jul 1989

Clinical Trials associated with Maxillary Sinusitis

CTR20243582 / RecruitingNot Applicable

中国健康受试者空腹和餐后口服STBN的随机、开放、两序列、两周期、双交叉设计的生物等效性试验

[Translation] A randomized, open-label, two-sequence, two-period, double-crossover bioequivalence study of fasting and fed oral administration of STBN in healthy Chinese subjects

主要研究目的研究空腹和餐后状态下单次口服受试制剂头孢地尼干混悬剂（规格：250mg/5ml，广东万泰科创药业有限公司提供）与参比制剂头孢地尼干混悬剂（规格：250mg/5ml，持证商：Aurobindo Pharma Limited），在健康成年受试者体内的药代动力学，评价空腹和餐后口服两种制剂的生物等效性。次要研究目的评价中国健康受试者空腹和餐后状态下，单次口服受试制剂头孢地尼干混悬剂和参比制剂头孢地尼干混悬剂后的安全性。

[Translation]

Main study objectives To study the pharmacokinetics of the test preparation cefdinir dry suspension (specification: 250mg/5ml, provided by Guangdong Wantai Kechuang Pharmaceutical Co., Ltd.) and the reference preparation cefdinir dry suspension (specification: 250mg/5ml, licensee: Aurobindo Pharma Limited) in healthy adult subjects after a single oral administration in the fasting and fed state, and to evaluate the bioequivalence of the two preparations after fasting and fed oral administration. Secondary study objectives To evaluate the safety of the test preparation cefdinir dry suspension and the reference preparation cefdinir dry suspension after a single oral administration in the fasting and fed state in healthy Chinese subjects.

Start Date29 Sep 2024

Sponsor / Collaborator

Guang Dong Wan Tai Ke Chuang Yao Ye You Xian Gong Si

CTR20242859 / CompletedNot Applicable

头孢地尼干混悬剂在健康受试者中单中心、随机、开放、两制剂、单次给药、两周期、双交叉空腹/餐后生物等效性试验研究方案

[Translation] Study plan for a single-center, randomized, open-label, two-formulation, single-dose, two-period, double-crossover fasting/fed bioequivalence trial of cefdinir dry suspension in healthy subjects

主要目的：以药代动力学参数作为主要终点评价指标，分别比较在空腹/餐后状态下口服受试制剂头孢地尼干混悬剂（生产厂家：苏州第三制药厂有限责任公司）与参比制剂头孢地尼干混悬剂（持证商：Aurobindo Pharma Limited）后在健康受试者体内的药代动力学行为，评价两种制剂的生物等效性。

[Translation]

Main objective: To compare the pharmacokinetic parameters as the primary endpoint evaluation indicators, the pharmacokinetic behavior of the test preparation cefdinir dry suspension (manufacturer: Suzhou Third Pharmaceutical Factory Co., Ltd.) and the reference preparation cefdinir dry suspension (licensed manufacturer: Aurobindo Pharma Limited) in healthy subjects after oral administration in the fasting/postprandial state, and to evaluate the bioequivalence of the two preparations.

Start Date10 Sep 2024

Sponsor / Collaborator

Suzhou No.3 Pharmaceutical Factory Co., Ltd.

CTR20242482 / CompletedNot Applicable

盐酸米诺环素胶囊（50 mg）在健康受试者中的空腹和餐后生物等效性试验

[Translation] Bioequivalence study of minocycline hydrochloride capsules (50 mg) in healthy subjects after fasting and feeding

主要目的：在健康受试者中，评价Pfizer Japan Inc.持证的参比制剂盐酸米诺环素胶囊（MINOMYCIN，50 mg （按C23H27N3O7计））与浙江华海制药科技有限公司生产的受试制剂盐酸米诺环素胶囊（50 mg（按C23H27N3O7计））在空腹和餐后条件下的生物等效性。次要目的：观察受试制剂盐酸米诺环素胶囊与参比制剂盐酸米诺环素胶囊（MINOMYCIN）在健康受试者中的安全性。

[Translation]

Primary objective: To evaluate the bioequivalence of the reference preparation minocycline hydrochloride capsules (MINOMYCIN, 50 mg (calculated as C23H27N3O7)) certified by Pfizer Japan Inc. and the test preparation minocycline hydrochloride capsules (50 mg (calculated as C23H27N3O7)) produced by Zhejiang Huahai Pharmaceutical Technology Co., Ltd. under fasting and fed conditions in healthy subjects. Secondary objective: To observe the safety of the test preparation minocycline hydrochloride capsules and the reference preparation minocycline hydrochloride capsules (MINOMYCIN) in healthy subjects.

Start Date02 Aug 2024

Sponsor / Collaborator

Zhejiang Huahai Pharmaceutical Technology Co., Ltd.

100 Clinical Results associated with Maxillary Sinusitis

100 Translational Medicine associated with Maxillary Sinusitis

0 Patents (Medical) associated with Maxillary Sinusitis

2,474

Literatures (Medical) associated with Maxillary Sinusitis

01 Dec 2024·Otolaryngologic Clinics of North America

Dental Pathophysiology of Odontogenic Sinusitis

Review

Author: Versiani, Marco Aurélio ; Silva, Emmanuel João Nogueira Leal ; Sassone, Luciana Moura ; Pinto, Karem Paula

Bacterial odontogenic sinusitis (ODS) arises from maxillary dental issues or oral procedures, and affects at least the maxillary sinuses, with or without other paranasal sinus involvement. It has been historically underreported, in contrast to more recent findings attributing 25-40% of chronic maxillary sinusitis to dental causes. Endodontic infections represent one of the most common causes of ODS. Endodontic factors like root canal infection and microbial proximity to sinus cavities play pivotal roles. Host immunological responses further shape disease severity and progression. This article aims to explore the complexity of endodontic infections that cause ODS, elucidating anatomical, microbial, and immunological aspects.

01 Dec 2024·Otolaryngologic Clinics of North America

Epidemiology of Odontogenic Sinusitis

Review

Author: Tröltzsch, Matthias

Odontogenic sinusitis (ODS) is more common than historically thought, representing 25% to 40% of all maxillary sinusitis. Due to a lack of widely accepted diagnostic criteria and a specific international diagnostic code, a true overall prevalence is unknown. ODS may be caused by either a multitude of infectious dental pathologies or complications after dental procedures. The most common dental etiologies causing ODS are apical periodontitis (endodontic) and oroantral communication or fistula after dental extraction. Less commonly, ODS can evolve after dental implant or maxillary sinus bone grafting surgeries, infection of odontogenic cysts, or advanced periodontitis.

08 Oct 2024·Cureus

Incidence of Maxillary Sinus Disorders in Dental Patients Undergoing Cone-Beam Computed Tomography: A Retrospective Cross-Sectional Study

Article

Author: Hakami, Belqees ; Mohammed, Hana ; Ali, Sarra ; Abu Habiba, Bashair ; Elbashir, Meaad ; Gareeballah, Awadia ; Abdelrazig, Ali ; Kamal, Sarra ; Saidahmed, Sawsan ; Alshameri, Esam S ; Alshameri, Esam S ; Alamin, Asma

Background Cone-beam computed tomography (CBCT) was quickly adopted in dentistry settings due to its compact size, low cost, and minimal ionizing radiation dose when compared to medical computed tomography. CBCT generates three-dimensional (3D) images that are useful in a variety of oral and maxillofacial circumstances, including diagnosis and assessment of disease severity, treatment planning and delivery, and follow-up. A significant advantage of CBCT lies in its capability to recognize incidental findings. In the realm of dental CBCT imaging, incidental findings often involve the maxillary sinuses, temporomandibular joints, or other craniofacial structures. Objective To demonstrate the incidental findings of maxillary sinus disorders in dental patients undergoing CBCT for numerous indications. Methods A retrospective cross-sectional study was carried out using data extracted from the Picture Archiving and Communication System (PACS) of Pure Smile Dental Center and Dental College Teaching Hospitals in the Jazan region from September to December 2022. The study sample included a total of 70 patients who underwent orthodontics CBCT, most of whom were female (76%). Statistical analysis was performed using IBM SPSS Statistics for Windows, Version 27 (IBM Corp., Armonk, USA), along with descriptive statistics. Furthermore, chi-square tests and cross-tabulation were done to assess the relation between the study variables. A p-value <0.01 and <0.05 was considered statistically significant. Results The most common dental CBCT findings were root invasion (18.6%), followed by gingivitis (7.14%), and dental caries (4.29%). Of the 70 patients, 42 (60%) had maxillary sinus findings, including opacification (50%), sinusitis (40%), mucosal thickening (34.3%), and polyps (7.1%). Female patients had more frequency of incidental findings related to males (41.43% and 18.57%, respectively). Conclusion A high percentage of dental patients exhibited incidental maxillary sinus findings in CBCT scans, confirming the utility of CBCT as a precise imaging method for detecting paranasal sinus disorders. A holistic documentation of incidental findings is crucial for improving patient outcomes and treatment plans.

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Maxillary Sinusitis

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