[Translation] A randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, and pharmacokinetics of Yanhouning oral solution in healthy Chinese subjects

选择健康志愿者为受试者，从安全的初始剂量开始，通过剂量递增试验，观察人体对咽喉宁口服液的安全性和耐受性；检测健康人服用咽喉宁口服液后，血浆中苦参碱、氧化苦参碱、金雀花碱、N-甲基金雀花碱、龙葵碱、澳洲茄碱、澳洲茄边碱、β-澳洲茄边碱、α-卡茄碱的浓度，研究其在人体的暴露情况，为制定本品的Ⅱ期临床试验给药方案和质量控制提供数据支持。

[Translation]

Healthy volunteers were selected as subjects, and starting from a safe initial dose, a dose escalation test was conducted to observe the safety and tolerability of the Yanhou Ning oral liquid in humans. The concentrations of matrine, oxymatrine, cytisine, N-methyl cytisine, solanine, chaconine, chaconine, β-chaconine, and α-chaconine in plasma were tested after healthy people took the Yanhou Ning oral liquid, and their exposure in humans was studied to provide data support for the formulation of the dosing regimen and quality control for the Phase II clinical trial of this product.

Start Date06 Sep 2021

Sponsor / Collaborator

Suzhou Youseen New Drug R&D Co. Ltd.

CTR20201043 / RecruitingPhase 1

一项旨在中国健康受试者中评价咽喉宁口服液安全性、耐受性和药代动力学的随机、双盲、安慰剂对照研究

[Translation] A randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, and pharmacokinetics of Yanhouning oral solution in healthy Chinese subjects

评价健康受试者对咽喉宁口服液的耐受程度，探索咽喉宁口服液的最大耐受剂量，获得安全剂量范围。

[Translation]

To evaluate the tolerance of healthy subjects to Yanhou Ning oral liquid, explore the maximum tolerated dose of Yanhou Ning oral liquid, and obtain the safe dose range.

Start Date08 May 2020

Sponsor / Collaborator

Suzhou Youseen New Drug R&D Co. Ltd.

CTR20160640 / RecruitingPhase 2

银马抗病毒颗粒治疗急性咽炎急性卡他性扁桃体炎（风热外犯证）有效、安全性随机双盲、平行对照Ⅱ期临床试验

[Translation] A randomized double-blind, parallel controlled phase II clinical trial on the effectiveness and safety of Yinma Antiviral Granules in the treatment of acute pharyngitis and acute catarrhal tonsillitis (wind-heat syndrome).

观察银马抗病毒颗粒治疗急性咽炎和急性卡他性扁桃体炎（风热外犯证）的有效性和安全性，并进行剂量探索。

[Translation]

To observe the efficacy and safety of Yinma Antiviral Granules in the treatment of acute pharyngitis and acute catarrhal tonsillitis (wind-heat exogenous syndrome), and to explore the dosage.

Start Date14 Dec 2016

Sponsor / Collaborator

Jiangxi Wanji Pharmaceutical Research Institute Co., Ltd.

100 Clinical Results associated with Acute catarrhal tonsillitis

100 Translational Medicine associated with Acute catarrhal tonsillitis

0 Patents (Medical) associated with Acute catarrhal tonsillitis

Literatures (Medical) associated with Acute catarrhal tonsillitis

31 Dec 2023·Virulence

Resistin secreted by porcine alveolar macrophages leads to endothelial cell dysfunction during Haemophilus parasuis infection

Article

Author: He, Yanling ; Guan, Aohan ; Li, Tingting ; Zhao, Ling ; Wang, Haoyu ; Jin, Hui ; Chen, Liying ; Luo, Rui ; Gao, Yuan ; Hua, Kexin ; Xu, Qianshuan

Haemophilus parasuis (H. parasuis) causes exudative inflammation, implying endothelial dysfunction during pathogen infection. However, so far, the molecular mechanism of endothelial dysfunction caused by H. parasuis has not been clarified. By using the transwell-based cell co-culture system, we demonstrate that knocking out resistin in porcine alveolar macrophages (PAMs) dramatically attenuated endothelial monolayer damage caused by H. parasuis. The resistin secreted by PAMs inhibited the expression of the tight junction proteins claudin-5 and occludin rather than the adherens junction protein VE-cadherin in co-cultured porcine aortic endothelial cells (PAECs). Furthermore, we demonstrate that resistin regulated claudin-5 and occludin expression and monolayer PAEC permeability in an LKB1/AMPK/mTOR pathway-dependent manner. Additionally, we reveal that the outer membrane lipoprotein gene lppA in H. parasuis induced resistin expression in PAMs, as deleting lppA reduced resistin expression in H. parasuis-infected PAMs, causing a significant change in LKB1/AMPK/mTOR pathway activity in co-cultured PAECs, thereby restoring tight junction protein levels and endothelial monolayer permeability. Thus, we postulate that the H. parasuis lppA gene enhances resistin production in PAMs, disrupting tight junctions in PAECs and causing endothelial barrier dysfunction. These findings elucidate the pathogenic mechanism of exudative inflammation caused by H. parasuis for the first time and provide a more profound angle of acute exudative inflammation caused by bacteria.

01 Jan 2023·Vestnik otorinolaringologii

Shaping approaches to standardization of oropharynx mucous membrane assessment of immunological parameters

Article

Author: Gerasimov, A N ; Kozlov, I G ; Bessonov, K K ; Savlevich, E L ; Zurochka, A V ; Gildeeva, G N ; Markus, P V ; Doroshchenko, N E ; Gaponov, A M

Basis of acute pharyngitis pathogenesis is an inflammatory process at the entrance gate of the infection. Therefore, local immunity study proves to be the most informative. Difficulty in making that type of assessment is lack of generally accepted reference values and biological sampling techniques.OBJECTIVEValidation of biological sampling techniques to study the parameters of local mucosal immunity in oropharynx acute inflammatory diseases.MATERIAL AND METHODS30 people with acute catarrhal pharyngitis with intoxication syndrome were examined. The sampling was carried out in 7 different ways. 1. Collect saliva samples using the passive drool collection method. 2. Collect saliva, using cotton swabs placed into the mouth for 3 minutes. 3. Cotton swabs wrapped around a metal probe was placed on palatine tonsils and lateral walls of the oropharynx. 4. Instead of a cotton swab, a disc of laboratory filter paper with a diameter of 0.7 cm was used. 5. Scrape by the mucous membrane of the palatine tonsils and lateral walls of the oropharynx were made with a cytobrush. 6. Using a cytobrush, scrapings were made from the mucous membrane of only the posterior pharyngeal wall, excluding the region of the palatine tonsils. 7. Using a cytobrush to make scrapings from the only palatine tonsils mucous membrane. RT-PCR was used to determine IL-1β mRNA.RESULTSMinimal IL-1β mRNA values were detected in saliva collected by passive flow (0.095 [0; 3.45] units) and on a cotton swab (0.21 [0.1; 3.82] units). IL-1β mRNA in the material collected by methods No. 3 and No. 4 on a cotton swab and a paper disk did not differ significantly from each other. Its level was higher than in saliva and lower than in scrapings. The maximum result was revealed with method No. 5 when simultaneously taking scrapings from the palatine tonsils and posterior pharyngeal wall mucous membrane (4.76 [0.92; 8.13] units). The expression of IL-1β mRNA in the material obtained by methods No. 6 and No. 7 did not differ significantly from each other.CONCLUSIONSeparated scrapings collecting from the palatine tonsils or posterior pharyngeal wall mucous membrane will allow assessing the inflammatory response autonomously in the lymphoid tissue and separately on the mucosa of the posterior pharyngeal wall. The mucosal scraping technique was the most effective for assessing cytokines in the oropharyngeal mucosal membrane.

01 Sep 2020·Biomeditsinskaya Khimiya

Comparative effect of the prolyl endopeptidase inhibitors, benzyloxycarbonyl-prolyl-prolinal and benzyloxycarbonyl-methionyl-cyanopyrrolidine, on the acute exudative inflammation and visceral pain in mice

Article

Author: Zolotov, N.N. ; Voronina, T.A. ; Ivanova, E.A.

A selective prolyl endopeptidase (PEP) inhibitor benzyloxycarbonyl-prolyl-prolinal (IC50 = 1,61±0,12 nmol/l) and a nonselective PEP inhibitor benzyloxycarbonyl-methionyl-cyanopyrrolidine (IC50 = 2,01±0,14 nmol/l) exhibit a comparable antiexudative effect at single doses of 2 mg/kg and 5 mg/kg (intraperitoneally) in outbred mice with peritonitis induced by 1% acetic acid. However, only benzyloxycarbonyl-methionyl-cyanopyrrolidine at a dose of 5 mg/kg reduces acetic acid induced pain in animals.

Analysis

Perform a panoramic analysis of this field.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Acute catarrhal tonsillitis

Basic Info

Related

Analysis