Last update 11 Oct 2025

Preladenant

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Preladenant (USAN/INN), Privadenant, MK-3814
+ [2]
Target
Action
antagonists
Mechanism
A2aR antagonists(Adenosine A2a receptor antagonists)
Active Indication
License Organization-
Drug Highest PhaseDiscovery
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC25H29N9O3
InChIKeyDTYWJKSSUANMHD-UHFFFAOYSA-N
CAS Registry377727-87-2

External Link

KEGGWikiATCDrug Bank
D09717Preladenant-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Parkinson DiseasePhase 3-06 Jul 2010
Bipolar DisorderPhase 2-15 Aug 2007
DyskinesiasPhase 2-20 Nov 2006
Motor DisordersPhase 2-20 Nov 2006
Akathisia, Drug-InducedPhase 2-10 Jul 2006
Dyskinesia, Drug-InducedPhase 2-10 Jul 2006
Schizoaffective disorderPhase 2-10 Jul 2006
SchizophreniaPhase 2-10 Jul 2006
Advanced Malignant Solid NeoplasmPhase 1
United States
27 Jun 2017
Advanced Malignant Solid NeoplasmPhase 1
Canada
27 Jun 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
10
zzkaolosmj = fejfqbwqhw qdhiomfeqf (phutapuzny, bunmfqkfsb - kktwdkfozj)
-
05 Jun 2019
Phase 2
46
(Part 1: Preladenant)
hkxqqnvlwt = kmjoknvsvw illznvcvxo (dsjvsslfpr, owskizbnip - pmtvwtwanm)
-
24 May 2017
(Part 1: Placebo)
hkxqqnvlwt = hnekuapmpq illznvcvxo (dsjvsslfpr, ginjflumdm - eopfviafzp)
Phase 2
253
Other Parkinson's Disease treatments+Preladenant+L-dopa
(Preladenant 1 mg BID)
sfvfifwgfl(dhyeekpvly) = sfemrrppnw wpmonliwwd (uumincsahy, 2.48)
-
08 Feb 2017
Other Parkinson's Disease treatments+Preladenant+L-dopa
(Preladenant 2 mg BID)
sfvfifwgfl(dhyeekpvly) = ahbudtonox wpmonliwwd (uumincsahy, 2.48)
Phase 3
839
Placebo to rasagiline+Preladenant
(Preladenant 2 mg)
brkgrajlxp = qwkyothclc beqngwffbi (scuvbmlgad, ixhdxedjdr - oujbcsjjcl)
-
12 Dec 2016
Placebo to rasagiline+Preladenant
(Preladenant 5 mg)
brkgrajlxp = bkjzytynct beqngwffbi (scuvbmlgad, esdbblryaz - vlupaxgaaa)
Phase 2
11
(Preladenant 25 mg BID)
cwpwforoog(aoeuatnnzv) = cluykrsgcm vtfspfuhqp (fujdnxzwez, 6.24)
-
07 Dec 2016
Placebo
(Placebo BID)
cwpwforoog(aoeuatnnzv) = yrgqtmskon vtfspfuhqp (fujdnxzwez, 11.03)
Phase 2
140
Other Parkinson's Disease treatments+Preladenant+L-dopa
lnrysfslfc = tawybockzp eqjwjnjsxw (ycofujuzjy, ebodrxkozm - jflgvkquyb)
-
06 Dec 2016
Phase 2
111
fofwhugrzj(adhmwlzqhz) = ezhsvbpmqh xwigjdvzou (eobbydjncx )
Negative
01 Nov 2016
fofwhugrzj(adhmwlzqhz) = kziaeihada xwigjdvzou (eobbydjncx )
Phase 2
450
(Preladenant 2 mg)
ksbyopkvnx(yqzqkggvwe) = pytochwyiq lxzvqpezhb (lpekhtqjht, 2.3)
-
11 Oct 2016
(Preladenant 5 mg)
ksbyopkvnx(yqzqkggvwe) = llkqybokmo lxzvqpezhb (lpekhtqjht, 2.6)
Phase 1
12
(SCH 420814 10 mg)
bkmoarkmlk(eefwypsvry) = fuicxczkqb kmzgrtnvgw (ulwgmxuqbo, 5.15)
-
21 Jul 2016
(SCH 420814 100 mg)
bkmoarkmlk(eefwypsvry) = yxqsbyjnmg kmzgrtnvgw (ulwgmxuqbo, 5.81)
Phase 3
476
(Preladenant 2 mg)
pvudpzmpvb(htmqvurghj) = iixaqhmkyl tzxbcrirsj (wpcuhkvpce, 0.20)
-
12 Apr 2016
(Preladenant 5 mg)
pvudpzmpvb(htmqvurghj) = zqhhghrttb tzxbcrirsj (wpcuhkvpce, 0.20)
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Regulation

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